Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Ewell, R"'
Publikováno v:
In Journal of Power Sources 2003 119:906-910
Autor:
Carpino, Philip A, Lefker, Bruce A, Toler, Steven M, Pan, Lydia C, Hadcock, John R, Cook, Ewell R, DiBrino, Joseph N, Campeta, Anthony M, DeNinno, Shari L, Chidsey-Frink, Kristin L, Hada, William A, Inthavongsay, John, Mangano, F.Michael, Mullins, Michelle A, Nickerson, David F, Ng, Oicheng, Pirie, Christine M, Ragan, John A, Rose, Colin R, Tess, David A, Wright, Ann S, Yu, Li, Zawistoski, Michael P, DaSilva-Jardine, Paul A, Wilson, Theresa C, Thompson, David D
Publikováno v:
In Bioorganic & Medicinal Chemistry 2003 11(4):581-590
Publikováno v:
Journal of Chemical Physics; Apr1938, Vol. 6 Issue 4, p205-218, 14p
Autor:
Oicheng Ng, John Inthavongsay, Theresa C. Wilson, Bruce Allen Lefker, Anthony Michael Campeta, Ann S. Wright, Hada William Andrew, John R. Hadcock, David A. Tess, Lydia C. Pan, K.L. Chidsey-Frink, F.Michael Mangano, Steven M. Toler, Colin R. Rose, Ewell R. Cook, Li Yu, C.M. Pirie, David F. Nickerson, Shari L. DeNinno, Joseph DiBrino, John A. Ragan, Paul DaSilva-Jardine, Michelle A. Mullins, David D. Thompson, Philip A. Carpino, Michael P. Zawistoski
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:581-590
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin ( 5 , CP-424391-18, hGHS-R1a K i =7 nM, rat pituicyte EC 50 =3 nM) and the des-methyl analogue 5c (
Autor:
John Inthavongsay, Theresa C. Wilson, Li Yu, Colin R. Rose, Hada William Andrew, Oicheng Ng, John R. Hadcock, David D. Thompson, David F. Nickerson, Michelle A. Mullins, Steven M. Toler, F.Michael Mangano, Paul DaSilva-Jardine, Ewell R. Cook, Bruce Allen Lefker, C.M. Pirie, David A. Tess, Lydia C. Pan, Lewis Sharon K, Michael P. Zawistoski, Ann S. Wright, Joseph DiBrino, K.L. Chidsey-Frink, Murray Marianne C, Philip A. Carpino, Shari L. DeNinno, John C. Pettersen, John A. Ragan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3279-3282
New tert -butyl, picolyl and fluorinated analogues of capromorelin ( 3 ), a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to identify long-acting GHSs that increase 24-h plasma IGF-1 levels. Compounds 4c and 4d (A
Autor:
M. Walid Qoronfleh, D. M. Schneider, Karen J. Vavra, Richard B. Ciccarelli, Joseph Falvo, Ewell R. Cook, Alan M. Mathiowetz, Haiyan Wang, Robert C. Wahl, Martin J. Dellwo, Mark A. McCoy, T. M. Banks, Tricia A. Pulvino
Publikováno v:
Journal of Biomolecular NMR. 9:11-24
We report here the backbone 1HN, 15N, 13Cα, 13CO, and 1Hα NMR assignmentsfor the catalytic domain of human fibroblast collagenase (HFC). Three independentassignment pathways (matching 1H, 13Cα, and 13CO resonances) were used to establishsequential
Autor:
Madhusudhan Reddy Gowravaram, Alan M. Mathiowetz, Robert C. Wahl, Bruce E. Tomczuk, Jeffrey Johnson, John C. Spurlino, Byron Rubin, Douglas L. Smith, Daniel Delecki, Tricia A. Pulvino, Ewell R. Cook, Arup K. Ghose
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:343-348
Structure-based drug design (SBDD) and traditional SAR have guided the development of potent and selective hydroxamate inhibitors which contain heteroatom-based modifications of the P1′ group. These inhibitors may help delineate the in vivo roles o
Autor:
Tricia A. Pulvino, Robert C. Wahl, Madhusudhan Reddy Gowravaram, Ewell R. Cook, Bruce E. Tomczuk, Arup K. Ghose, Alan M. Mathiowetz, Daniel Delecki, Jeffrey Johnson, James A. Gainor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:349-352
Gelatinase B is potently inhibited by peptide hydroxamates, including molecules that have a R 1 ′ group which is larger than the side chains of the natural amino acids.
Autor:
Philip A, Carpino, Bruce A, Lefker, Steven M, Toler, Lydia C, Pan, John R, Hadcock, Ewell R, Cook, Joseph N, DiBrino, Anthony M, Campeta, Shari L, DeNinno, Kristin L, Chidsey-Frink, William A, Hada, John, Inthavongsay, F Michael, Mangano, Michelle A, Mullins, David F, Nickerson, Oicheng, Ng, Christine M, Pirie, John A, Ragan, Colin R, Rose, David A, Tess, Ann S, Wright, Li, Yu, Michael P, Zawistoski, Paul A, DaSilva-Jardine, Theresa C, Wilson, David D, Thompson
Publikováno v:
Bioorganicmedicinal chemistry. 11(4)
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin (5, CP-424391-18, hGHS-R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM) and the des-methyl analogue 5c (hG
Autor:
Ravi B. Marala, Allan R. Buchholz, Delvin R. Knight, Scott P. Kennedy, Wester Ronald Thure, Paul J. Kowalczyk, Roger J. Hill, Roger B. Ruggeri, Angel Guzman-Perez, Ewell R. Cook, Mary C. Allen, Day Wesley Warren, Janice A. Brown, Mularski Christian J, William Albert Novomisle, W. Ross Tracey, Hamanaka Ernest S
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(6)
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of thi