Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ewelina M Krysztofinska"'
Autor:
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date have elab
Externí odkaz:
https://doaj.org/article/676e5fcd8544472ba7c52603d7ecf995
Autor:
Santiago Martínez-Lumbreras, Ewelina M. Krysztofinska, Arjun Thapaliya, Alessandro Spilotros, Dijana Matak-Vinkovic, Enrico Salvadori, Peristera Roboti, Yvonne Nyathi, Janina H. Muench, Maxie M. Roessler, Dmitri I. Svergun, Stephen High, Rivka L. Isaacson
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-18 (2018)
Abstract Background Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are captured in the aqueou
Externí odkaz:
https://doaj.org/article/8625f0069c5e4497b8864944055a9f70
Autor:
Ewelina M. Krysztofinska, Nicola J. Evans, Arjun Thapaliya, James W. Murray, Rhodri M. L. Morgan, Santiago Martinez-Lumbreras, Rivka L. Isaacson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Small glutamine-rich tetratricopeptide repeat-containing protein 2 (Sgt2) is a multi-module co-chaperone involved in several protein quality control pathways. The TPR domain of Sgt2 and several other proteins, including SGTA, Hop, and CHIP, is a high
Externí odkaz:
https://doaj.org/article/fa831935d71b41519e0ed81dc0364b1e
Autor:
John F Darby, Ewelina M Krysztofinska, Peter J Simpson, Aline C Simon, Pawel Leznicki, Newran Sriskandarajah, David S Bishop, Lisa R Hale, Caterina Alfano, Maria R Conte, Santiago Martínez-Lumbreras, Arjun Thapaliya, Stephen High, Rivka L Isaacson
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113281 (2014)
The BAG6 complex resides in the cytosol and acts as a sorting point to target diverse hydrophobic protein substrates along their appropriate paths, including proteasomal degradation and ER membrane insertion. Composed of a trimeric complex of BAG6, T
Externí odkaz:
https://doaj.org/article/8e8a952f4dc54536822cf9d134d1aff8
Autor:
Pawel Leznicki, Quentin P Roebuck, Lydia Wunderley, Anne Clancy, Ewelina M Krysztofinska, Rivka L Isaacson, Jim Warwicker, Blanche Schwappach, Stephen High
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59590 (2013)
The BAG6 protein is a subunit of a heterotrimeric complex that binds a range of membrane and secretory protein precursors localized to the cytosol, enforcing quality control and influencing their subsequent fate.BAG6 has an N-terminal ubiquitin-like
Externí odkaz:
https://doaj.org/article/64d12d24e67b4b8f877d17a4d74feb1f
Autor:
Ann Hochschild, Caterina Alfano, Ewelina M. Krysztofinska, Rivka L. Isaacson, Cinthia P. Garcia, Anna F. Wang Erickson, Padraig Deighan, Kelsey Barrasso, Santiago Martínez-Lumbreras, Richard Losick, Arjun Thapaliya, Amy H. Camp, Shanshan Chen
Publikováno v:
Wang Erickson, A F, Deighan, P, Chen, S, Barrasso, K, Garcia, C P, Martínez-Lumbreras, S, Alfano, C, Krysztofinska, E M, Thapaliya, A, Camp, A H, Isaacson, R L, Hochschild, A & Losick, R 2017, ' A Novel RNA Polymerase-binding Protein that interacts with a Sigma-Factor Docking Site ', Molecular Microbiology . https://doi.org/10.1111/mmi.13724
Sporulation in Bacillus subtilis is governed by a cascade of alternative RNA polymerase sigma factors. We previously identified a small protein Fin that is produced under the control of the sporulation sigma factor σ(F) to create a negative feedback
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a07e2951497dcbc147b45bdebb8c04
https://doi.org/10.1111/mmi.13724
https://doi.org/10.1111/mmi.13724
Autor:
Peter Simpson, Stephen High, Rachael M. Goldstone, Aline C. Simon, James W. Murray, Rivka L. Isaacson, Ewelina M. Krysztofinska
Publikováno v:
Proceedings of the National Academy of Sciences. 110:1327-1332
Small, glutamine-rich, tetratricopeptide repeat protein 2 (Sgt2) is the first known port of call for many newly synthesized tail-anchored (TA) proteins released from the ribosome and destined for the GET (Guided Entry of TA proteins) pathway. This le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9db10d94646c54c9b3b79129670b73
https://doi.org/10.1073/pnas.1207518110
https://doi.org/10.1073/pnas.1207518110
Autor:
Santiago Martínez-Lumbreras, Isabelle L. Terry, Nicola J. Evans, Rivka L. Isaacson, Arjun Thapaliya, Ewelina M. Krysztofinska, Yvonne Nyathi, Stephen High
Publikováno v:
Thapaliya, A, Nyathi, Y, Martinez Lumbreras, S, Krysztofinska, E, Evans, N, Terry, I L, High, S & Isaacson, R L 2016, ' SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism ', Scientific Reports, vol. 6, 36622 . https://doi.org/10.1038/srep36622
Scientific Reports
Scientific Reports
The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9973c1c2a73abba49351a59e4b4e32
https://kclpure.kcl.ac.uk/en/publications/464dc9fe-eeac-4f4d-876a-904299e8849e
https://kclpure.kcl.ac.uk/en/publications/464dc9fe-eeac-4f4d-876a-904299e8849e
Autor:
Ewelina M, Krysztofinska, Santiago, Martínez-Lumbreras, Arjun, Thapaliya, Nicola J, Evans, Stephen, High, Rivka L, Isaacson
Publikováno v:
Scientific Reports
RNF126 is an E3 ubiquitin ligase that collaborates with the BAG6 sortase complex to ubiquitinate hydrophobic substrates in the cytoplasm that are destined for proteasomal recycling. Composed of a trimeric complex of BAG6, TRC35 and UBL4A the BAG6 sor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea33ee962d6aa144b6a411d7242ac14c
https://pubmed.ncbi.nlm.nih.gov/27193484
https://pubmed.ncbi.nlm.nih.gov/27193484
Autor:
Rivka L. Isaacson, Ewelina M. Krysztofinska, Joanna D. Roberts, Arjun Thapaliya, Santiago Martínez-Lumbreras
Publikováno v:
Frontiers in Molecular Biosciences, Vol 2 (2015)
Frontiers in Molecular Biosciences
Roberts, J D, Thapaliya, A, Martínez-Lumbreras, S, Krysztofinska, E M & Isaacson, R L 2015, ' Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha ', Frontiers in Bioscience, vol. 2, pp. 71 . https://doi.org/10.3389/fmolb.2015.00071
Frontiers in Molecular Biosciences
Roberts, J D, Thapaliya, A, Martínez-Lumbreras, S, Krysztofinska, E M & Isaacson, R L 2015, ' Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha ', Frontiers in Bioscience, vol. 2, pp. 71 . https://doi.org/10.3389/fmolb.2015.00071
The small glutamine-rich, tetratricopeptide repeat-containing protein alpha (SGTA) is an emerging player in the quality control of secretory and membrane proteins mislocalized to the cytosol, with established roles in tail-anchored (TA) membrane prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24867a9a9c804f607cd942709420213