Diverse ultrastructural landscape of atherosclerotic endothelium

Autor: Ewelina Kluza, Annelie Shami, Thijs J. Beldman, Anita E. Grootemaat, Willem J. M. Mulder, Esther Lutgens, Stephan Huveneers, Nicole N. van der Wel, Tsveta S. Malinova, Edwin R. Scholl, Isabel Gonçalves

Publikováno v: Atherosclerosis, 339, 35-45. Elsevier Ireland Ltd
Atherosclerosis, 339, 35-45
Atherosclerosis, 339, pp. 35-45

Contains fulltext : 245675.pdf (Publisher’s version ) (Open Access) BACKGROUND AND AIMS: The endothelium plays a major role in atherosclerosis, yet the endothelial plaque surface is a largely uncharted territory. Here we hypothesize that atheroscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f3fc89806f5f96a2efe574ef5d3d70
http://www.scopus.com/inward/record.url?scp=85119987822&partnerID=8YFLogxK

Nanoengineering Apolipoprotein A1-Based Immunotherapeutics

Autor: Ewelina Kluza, Floor Ummels, Eveline G. Nugraha, Stijn R. J. Hofstraat, Thijs J. Beldman, Tom Anbergen, Zahi A. Fayad, Roy van der Meel, Mirre M. Trines, David P. Schrijver, Anne de Dreu, Jeroen Deckers, Willem J. M. Mulder, Rutger J. Röring, Koen de Bruin, Abraham J. P. Teunissen, Robby Zwolsman

Publikováno v: Advanced Therapeutics, 4(8):2100083. Wiley-VCH Verlag

In the slipstream of targeting the adaptive immune system, innate immunotherapy strategies are being developed. In this context, technologies based on natural carrier vehicles that inherently interact with the innate immune system, are increasingly b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c115ad859a83fa67efa84313c19f5e05
https://doi.org/10.1002/adtp.202100083

Nuclear imaging approaches facilitating nanomedicine translation

Autor: Willem J. M. Mulder, Carlos Pérez-Medina, Roy van der Meel, Abraham J. P. Teunissen, Ewelina Kluza

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)

Nanomedicine approaches can effectively modulate the biodistribution and bioavailability of therapeutic agents, improving their therapeutic index. However, despite the ever-increasing amount of literature reporting on preclinical nanomedicine, the nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba9daad78cd09d6c4eb1ff2f0c1c798
https://hdl.handle.net/20.500.12105/12601

Shedding 3D light on endothelial barrier function in arteries

Autor: Ewelina Kluza

Publikováno v: Atherosclerosis, 310, 91-92. Elsevier Ireland Ltd

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Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Autor: Mandy M. T. van Leent, Jazz Munitz, Yiming Zhao, Georgios Soultanidis, Anu E. Meerwaldt, Rick M. Dijkhuizen, Esther M. van Leeuwen, Jordi Ochando, Mihai G. Netea, Anna Vera D Verschuur, Thomas Reiner, Yohana C. Toner, Eva Zupančič, Raphaël Duivenvoorden, Hidde L. Ploegh, Sjoerd Hak, Alexander Rialdi, Leo A. B. Joosten, Lisa Willemsen, Ernesto Guccione, Willem J. M. Mulder, Denis Torre, Arjan W. Griffioen, Mohammad Rashidian, Vera P. Mourits, Zahi A. Fayad, Bram Priem, Roderick S. Oosterwijk, Abraham J. P. Teunissen, Emma D. Klein, Paul H. H. Bomans, Karen A.M. de Jong, Heiner Friedrich, Jose Javier Bravo-Cordero, Julie Di Martino, Alexandros Marios Sofias, Claudia Calcagno, Andrea van Elsas, Ewelina Kluza, Geoffrey Prévot, Carlos Pérez-Medina, Nico A. J. M. Sommerdijk, Menno P.J. de Winther, Sheqouia A. Nauta, Elizabeth L. Fisher

Publikováno v: Cell, 183(3), 786-801.e19. Cell Press
Priem, B, van Leent, M M T, Teunissen, A J P, Sofias, A M, Mourits, V P, Willemsen, L, Klein, E D, Oosterwijk, R S, Meerwaldt, A E, Munitz, J, Prévot, G, Vera Verschuur, A, Nauta, S A, van Leeuwen, E M, Fisher, E L, de Jong, K A M, Zhao, Y, Toner, Y C, Soultanidis, G, Calcagno, C, Bomans, P H H, Friedrich, H, Sommerdijk, N, Reiner, T, Duivenvoorden, R, Zupančič, E, Di Martino, J S, Kluza, E, Rashidian, M, Ploegh, H L, Dijkhuizen, R M, Hak, S, Pérez-Medina, C, Bravo-Cordero, J J, de Winther, M P J, Joosten, L A B, van Elsas, A, Fayad, Z A, Rialdi, A, Torre, D, Guccione, E, Ochando, J, Netea, M G, Griffioen, A W & Mulder, W J M 2020, ' Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition ', Cell, vol. 183, no. 3, pp. 786-801.e19 . https://doi.org/10.1016/j.cell.2020.09.059
Cell
Cell, 183, 3, pp. 786-801.e19
Cell, 183, 786-801.e19

Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a bone ma

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