Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ewelina Honkisz-Orzechowska"'
Autor:
Magdalena Łysakowska, Iwona E. Głowacka, Ewelina Honkisz-Orzechowska, Jadwiga Handzlik, Dorota G. Piotrowska
Publikováno v:
Molecules, Vol 29, Iss 13, p 3050 (2024)
In this study, a new series of cis and trans 5-substituted-3-(dibenzyloxyphosphoryl)isoxazolidines 16a–g were synthesized by the 1,3-dipolar cycloaddition reaction of N-benzyl-C-(dibenzyloxyphosphoryl)nitrone and selected N1-allyl-N3-benzylquinazol
Externí odkaz:
https://doaj.org/article/b6bb75c24596445f9790ed339e54bf83
Publikováno v:
Molecules, Vol 29, Iss 6, p 1258 (2024)
The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins. The role of these SPMs has been disc
Externí odkaz:
https://doaj.org/article/83d7208dabf44b74b88d8ee8337442dd
Autor:
Agnieszka Olejarz-Maciej, Szczepan Mogilski, Tadeusz Karcz, Tobias Werner, Katarzyna Kamińska, Jarosław Kupczyk, Ewelina Honkisz-Orzechowska, Gniewomir Latacz, Holger Stark, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Publikováno v:
Molecules, Vol 28, Iss 10, p 4199 (2023)
Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of inflammatory and immune diseases, as well as pain. H4R ligands have demonstrated analgesic effect
Externí odkaz:
https://doaj.org/article/a1345330633546a088998c7589f4d043
Autor:
Dorota Łażewska, Maria Kaleta, Paula Zaręba, Justyna Godyń, Mariam Dubiel, Ewelina Honkisz-Orzechowska, Agata Doroz-Płonka, Anna Więckowska, Holger Stark, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 28, Iss 5, p 2349 (2023)
Alzheimer’s disease (AD) is a neurodegenerative disorder, for which there is no effective cure. Current drugs only slow down the course of the disease, and, therefore, there is an urgent need to find effective therapies that not only treat, but als
Externí odkaz:
https://doaj.org/article/e4f4f258d08342fc9d582fd5b050fa49
Autor:
Dorota Łażewska, Małgorzata Więcek, Grzegorz Satała, Paulina Chałupnik, Ewa Żesławska, Ewelina Honkisz-Orzechowska, Monika Tarasek, Gniewomir Latacz, Wojciech Nitek, Ewa Szymańska, Jadwiga Handzlik
Publikováno v:
Molecules, Vol 28, Iss 3, p 1108 (2023)
Since the number of people with Alzheimer’s disease (AD) continues to rise, new and effective drugs are urgently needed to not only slow down the progression of the disease, but to stop or even prevent its development. Serotonin 5-HT6 receptor (5-H
Externí odkaz:
https://doaj.org/article/2818bbb54cea49789517aaf59945ee75
Autor:
Sabrina Garbo, Silvia Di Giacomo, Dorota Łażewska, Ewelina Honkisz-Orzechowska, Antonella Di Sotto, Rossella Fioravanti, Clemens Zwergel, Cecilia Battistelli
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 104 (2022)
Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-contai
Externí odkaz:
https://doaj.org/article/7dc09047977e45b1a873ba650af1785f
Autor:
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2187 (2022)
The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain. A series o
Externí odkaz:
https://doaj.org/article/9d182e4dcb5d4290bc05ad6a476c576a
Autor:
Gniewomir Latacz, Kinga Sałat, Anna Furgała-Wojas, Adrian Martyniak, Agnieszka Olejarz-Maciej, Ewelina Honkisz-Orzechowska, Ewa Szymańska
Publikováno v:
Molecules, Vol 27, Iss 3, p 875 (2022)
Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, were
Externí odkaz:
https://doaj.org/article/30c4052d21b04e6595507df4b292cee4
Autor:
Ewelina Honkisz-Orzechowska, Katarzyna Popiołek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzała, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek, Katarzyna Starowicz, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Objective Microglia play an important role in the neuroinflammation developed in response to various pathologies. In this study, we examined the anti-inflammatory effect of the new human histamine H3 receptor (H3R) ligands with flavonoid structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ac424a08557620521d417ef1b38124
https://ruj.uj.edu.pl/xmlui/handle/item/304866
https://ruj.uj.edu.pl/xmlui/handle/item/304866
Autor:
Ewelina, Honkisz-Orzechowska, Katarzyna, Popiołek-Barczyk, Zuzanna, Linart, Jadwiga, Filipek-Gorzała, Anna, Rudnicka, Agata, Siwek, Tobias, Werner, Holger, Stark, Jakub, Chwastek, Katarzyna, Starowicz, Katarzyna, Kieć-Kononowicz, Dorota, Łażewska
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
Microglia play an important role in the neuroinflammation developed in response to various pathologies. In this study, we examined the anti-inflammatory effect of the new human histamine HThe affinity of flavonoids (E243 -flavone and IIIa-IIIc-chalco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35d031673309b7b3afd6ed997b32ed75
https://pubmed.ncbi.nlm.nih.gov/36370200
https://pubmed.ncbi.nlm.nih.gov/36370200