Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ewart Kuijk"'
Autor:
Nicolle Besselink, Janneke Keijer, Carlo Vermeulen, Sander Boymans, Jeroen de Ridder, Arne van Hoeck, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeri
Externí odkaz:
https://doaj.org/article/a222b675a2064a8d8a7fbc7905355b5f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Specific anti-cancer therapies are highly mutagenic to cancer cells but the mutational impact on healthy tissues remains elusive. Here, the authors use organoids and whole-genome sequencing to characterise somatic mutations in healthy colon and liver
Externí odkaz:
https://doaj.org/article/ca064644a36449b692e6323f5bc540c5
Autor:
Judith M. Vlaar, Anouska Borgman, Eric Kalkhoven, Denise Westland, Nicolle Besselink, Charles Shale, Bishoy M. Faltas, Peter Priestley, Ewart Kuijk, Edwin Cuppen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Bladder cancer has a high recurrence rate and low survival of advanced stage patients. Few genetic drivers of bladder cancer have thus far been identified. We performed in-depth structural variant analysis on whole-genome sequencing data of
Externí odkaz:
https://doaj.org/article/888f55e99f70439995e314d90af004f1
Autor:
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver di
Externí odkaz:
https://doaj.org/article/96839cce3bec43feb376e5547a803268
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative
Externí odkaz:
https://doaj.org/article/1f6a475491464666a79c0e3f7512c41e
Autor:
Karlijn A.L. Hasaart, Freek Manders, Joske Ubels, Mark Verheul, Markus J. van Roosmalen, Niels M. Groenen, Rurika Oka, Ewart Kuijk, Susana M. Chuva de Sousa Lopes, Ruben van Boxtel
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103736- (2022)
Summary: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, but genetic instability is a major concern. Embryonic pluripotent cells also accumulate mutations during early development, but how this relates to the muta
Externí odkaz:
https://doaj.org/article/35c1315d16594b4f92d948fe5e60d5cc
Autor:
Sharon Christensen, Bastiaan Van der Roest, Nicolle Besselink, Roel Janssen, Sander Boymans, John W. M. Martens, Marie-Laure Yaspo, Peter Priestley, Ewart Kuijk, Edwin Cuppen, Arne Van Hoeck
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 fr
Externí odkaz:
https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc
Autor:
Ábel Vértesy, Wibowo Arindrarto, Matthias S. Roost, Björn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
In mammalian female germ cells, parent-specific epigenetic marks are erased and the X chromosome reactivated before entry into meiosis. Here, by combining parental haplotype reconstruction with single-cell transcriptomics of human female embryonic ge
Externí odkaz:
https://doaj.org/article/2b4ac2ed364b4f8a93b6e4cd64a219b7
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ed8e577e7e504584b8fd4c8ae2098f00
Autor:
Roel Hermsen, Pim Toonen, Ewart Kuijk, Sameh A Youssef, Raoul Kuiper, Sebastiaan van Heesch, Alain de Bruin, Edwin Cuppen, Marieke Simonis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122066 (2015)
Tumorigenesis is often associated with loss of tumor suppressor genes (such as TP53), genomic instability and telomere lengthening. Previously, we generated and characterized a rat p53 knockout model in which the homozygous rats predominantly develop
Externí odkaz:
https://doaj.org/article/cd1fdc2f53104ad8b71c5f5850273ebb