Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Ewan St"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Itch (pruritus) is a sensation that drives a desire to scratch, a behavior observed in many animals. Although generally short-lasting and not causing harm, there are several pathological conditions where chronic itch is a hallmark symptom and in whic
Externí odkaz:
https://doaj.org/article/b73084822ff14b0cb6f6a48fffb147db
Publikováno v:
Frontiers in Communication, Vol 7 (2022)
Chronic gastrointestinal (GI) tract conditions, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are common conditions associated with disordered bowel movements and significant pain. However, discussion of bowel habits is
Externí odkaz:
https://doaj.org/article/4793d2f7a1c24670851e6a7544735cd0
Autor:
Brigitte M. Browe, Abigail R. Olsen, Cesar Ramirez, Rebecca H. Rickman, Ewan St. John Smith, Thomas J. Park
Publikováno v:
Neurobiology of Pain, Vol 8, Iss , Pp 100047- (2020)
Naked mole-rats (Heterocephalus glaber) have adaptations within their pain pathway that are beneficial to survival in large colonies within poorly ventilated burrow systems, with lower O2 and higher CO2 ambient levels than ground-level environments.
Externí odkaz:
https://doaj.org/article/4f5fe742a12a47258cac8ae46ff4e08d
Publikováno v:
Neurobiology of Pain, Vol 8, Iss , Pp 100051- (2020)
Pain arising from musculoskeletal disorders such as arthritis is one of the leading causes of disability. Whereas the past 20-years has seen an increase in targeted therapies for rheumatoid arthritis (RA), other arthritis conditions, especially osteo
Externí odkaz:
https://doaj.org/article/fd58f78d76e64ef58ec281f821c97668
Autor:
Toni S. Taylor, Parvesh Konda, Sarah S. John, David C. Bulmer, James R. F. Hockley, Ewan St. John Smith
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the a
Externí odkaz:
https://doaj.org/article/43d932d5034d41e1a77ebd1e7b62ce9e
Autor:
Zoé Husson, Ewan St. John Smith
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal excitability. Tissue acidosis, resulting from hypoxia or hypercapnia, can activate various protein
Externí odkaz:
https://doaj.org/article/5b752a70d9f048828f5ac441acdb9b89
Autor:
Sin-Lih Tan, Muruj Barri, Peace Atakpa-Adaji, Colin W. Taylor, Ewan St. John Smith, Ruth D. Murrell-Lagnado
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10492 (2021)
The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of P2X4 receptors and the
Externí odkaz:
https://doaj.org/article/b42bd61ed1eb4f83bc3e00ee1553ac14
Autor:
Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad A. D. Sharif, Celia Lujan, Ewan St. John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how
Externí odkaz:
https://doaj.org/article/057c5004ddb54609858a2e780a18b291
Autor:
Damir Omerbašić, Ewan St. J. Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C. Bennett, Jane Reznick, Chris G. Faulkes, Matthias Selbach, Gary R. Lewin
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 748-758 (2016)
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats.
Externí odkaz:
https://doaj.org/article/5a53381f1a6e4a2e9ea0fc3b22fdab77
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167079 (2016)
Although increasingly popular as a laboratory species, very little is known about the peripheral auditory system of the naked mole-rat, Heterocephalus glaber. In this study, middle and inner ears of naked mole-rats of a range of ages were examined us
Externí odkaz:
https://doaj.org/article/70bcaede8be34069b968b61ed693666a