Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ewan M. McNeil"'
Autor:
Liang Song, Ewan M. McNeil, Ann-Marie Ritchie, Katy R. Astell, Charlie Gourley, David W. Melton
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background The global incidence of melanoma has been increasing faster than any other form of cancer. New therapies offer exciting prospects for improved survival, but the development of resistance is a major problem and there remains a need
Externí odkaz:
https://doaj.org/article/7ad027d6ba824e33a5c51694505d0868
Autor:
Ewan M. McNeil
Publikováno v:
Marine Policy. 92:58-60
In the 1970s, Organotin compounds were extensively used as potent biocides in antifouling. Inadvertently Organotin caused adverse effects to shell fishing industries leading to the implementation of the International Maritime Organisation Internation
Autor:
David W. Melton, Douglas R. Houston, Preeti Bakrania, Martin A. Wear, Barbara Saxty, Ann Marie Ritchie, Steven Shave, Tim Chapman, Katy R. Astell, Puneet Khurana, Claire Wallace, Ewan M. McNeil, Malcolm D. Walkinshaw, Hayley M. Jones
Publikováno v:
McNeil, E M, Astell, K R, Ritchie, A-M, Shave, S, Houston, D R, Bakrania, P, Jones, H M, Khurana, P, Wallace, C, Chapman, T, Wear, M A, Walkinshaw, M D, Saxty, B & Melton, D W 2015, ' Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance ', DNA Repair, vol. 31, pp. 19-28 . https://doi.org/10.1016/j.dnarep.2015.04.002
ERCC1-XPF is a structure-specific endonuclease that is required for the repair of DNA lesions, generated by the widely used platinum-containing cancer chemotherapeutics such as cisplatin, through the Nucleotide Excision Repair and Interstrand Crossli
Publikováno v:
DNA Repair. 12:1000-1006
Nitrofurans are commonly used for the treatment of trypanosomal diseases including Chagas disease. More recently, following the fortuitous discovery that nifurtimox was clinically active against neuroblastoma, nitrofuran compounds are being investiga
Autor:
David W. Melton, Ewan M. McNeil
Publikováno v:
The Biochemist. 35:25-29
The DNA in the cells in our skin is damaged by UV irradiation. DNA repair pathways protect us against the carcinogenic consequences of unrepaired DNA damage, but the same DNA repair pathways can also protect life-threatening melanoma skin cancers fro
Autor:
David W. Melton, Ewan M. McNeil
Publikováno v:
McNeil, E M & Melton, D W 2012, ' DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy ', Nucleic Acids Research, vol. 40, no. 20, pp. 9990-10004 . https://doi.org/10.1093/nar/gks818
Nucleic Acids Research
Nucleic Acids Research
The ERCC1-XPF complex is a structure-specific endonuclease essential for the repair of DNA damage by the nucleotide excision repair pathway. It is also involved in other key cellular processes, including DNA interstrand crosslink (ICL) repair and DNA
Publikováno v:
Pigment Cell & Melanoma Research. 24:966-971
Summary Increased expression of DNA repair genes contributes to the extreme resistance shown by melanoma to conventional DNA-damaging chemotherapeutics. One such chemotherapeutic effective against a range of other cancers, but not melanoma, is cispla
Autor:
Mike Tyers, E. Elizabeth Patton, Stephen L. Johnson, Amy Mitchell, Nicholas D Temperley, Linna Zhou, Zhiqiang Zeng, Vikram Narayan, Hironori Ishizaki, Philippe Gautier, Michaela Spitzer, Terry K. Smith, Paul Brear, Kerrie L. Taylor, Ewan M. McNeil, Nicholas J. Westwood, David W. Melton
Publikováno v:
Zhou, L, Ishizaki, H, Spitzer, M, Taylor, K L, Temperley, N D, Johnson, S L, Brear, P, Gautier, P, Zeng, Z, Mitchell, A, Narayan, V, McNeil, E M, Melton, D W, Smith, T K, Tyers, M, Westwood, N J & Patton, E E 2012, ' ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species ', Chemistry and Biology, vol. 19, no. 7, pp. 883-892 . https://doi.org/10.1016/j.chembiol.2012.05.017
Chemistry & Biology
Cell Chemical Biology
Zhou, L, Ishizaki, H, Spitzer, M, Marie, K L, Temperley, N D, Johnson, S L, Brear, P, Gautier, P, Zeng, Z, Mitchell, A, Narayan, V, McNeil, E M, Melton, D W, Smith, T K, Tyers, M, Westwood, N J & Patton, E E 2012, ' ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species ', Chemistry and Biology, vol. 19, no. 7, pp. 883-892 . https://doi.org/10.1016/j.chembiol.2012.05.017
Chemistry & Biology
Cell Chemical Biology
Zhou, L, Ishizaki, H, Spitzer, M, Marie, K L, Temperley, N D, Johnson, S L, Brear, P, Gautier, P, Zeng, Z, Mitchell, A, Narayan, V, McNeil, E M, Melton, D W, Smith, T K, Tyers, M, Westwood, N J & Patton, E E 2012, ' ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species ', Chemistry and Biology, vol. 19, no. 7, pp. 883-892 . https://doi.org/10.1016/j.chembiol.2012.05.017
Summary Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5498887f2558c87adc021ade562285
https://hdl.handle.net/20.500.11820/b559230e-2186-49e2-bfde-143ddead3147
https://hdl.handle.net/20.500.11820/b559230e-2186-49e2-bfde-143ddead3147
Publikováno v:
Pigment cellmelanoma research. 24(5)
Increased expression of DNA repair genes contributes to the extreme resistance shown by melanoma to conventional DNA-damaging chemotherapeutics. One such chemotherapeutic effective against a range of other cancers, but not melanoma, is cisplatin. The