Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ewan M, Smith"'
Autor:
Wei-Ting Lu, Ben R. Hawley, George L. Skalka, Robert A. Baldock, Ewan M. Smith, Aldo S. Bader, Michal Malewicz, Felicity Z. Watts, Ania Wilczynska, Martin Bushell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The mechanism through which Drosha and Dicer affect DNA repair is not clear. Here the authors use a high-throughput approach to uncover the role of Drosha in promoting DNA:RNA hybrids at DNA damaged sites.
Externí odkaz:
https://doaj.org/article/4f06c76c0d594080bebcce6e6a2b7046
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
Joseph A. Waldron, Ania Wilczynska, Katherine Morris, Mark Stoneley, Kelvin Cain, Martin Bushell, Nour El Houda Benbahouche, Ewan M. Smith, Rebekah Jukes-Jones, Cameron Bell, Bruno D. Fonseca, Sarah P. Blagden, Carolyn Jones, Hedda A. Meijer, Sarah L. Gillen, Anne E. Willis, Tobias Schmidt
Publikováno v:
Nucleic Acids Research
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achieved, in pa
Autor:
Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell
Publikováno v:
Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652
https://doi.org/10.1158/2159-8290.CD-20-0652
Autor:
Bruno J Moraes, Bruno D. Fonseca, Michael T Solgaard, Yonghao Yu, Huy-Dung Hoang, Giovanna Celucci, Tommy Alain, Malik Chaker-Margot, Xu-Dong Wang, Roberta Pointet, Marius R. Niklaus, Jian-Jun Jia, Leonie Anton, Christopher Dajadian, Tyson E. Graber, Andrea J. Berman, Izabella A. Pena, Jaclyn Hearnden, Mark Livingstone, Roni M. Lahr, Anne Kruse Hollensen, Timm Maier, Christian Kroun Damgaard, Ewan M. Smith, An-Dao Yang
Publikováno v:
Jia, J-J, Lahr, R M, Solgaard, M T, Moraes, B J, Pointet, R, Yang, A-D, Celucci, G, Graber, T E, Hoang, H-D, Niklaus, M R, Pena, I A, Hollensen, A K, Smith, E M, Chaker-Margot, M, Anton, L, Dajadian, C, Livingstone, M, Hearnden, J, Wang, X-D, Yu, Y, Maier, T, Damgaard, C K, Berman, A J, Alain, T & Fonseca, B D 2021, ' mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 ', Nucleic Acids Research, vol. 49, no. 6, pp. 3461-3489 . https://doi.org/10.1093/nar/gkaa1239
Nucleic Acids Research
Nucleic Acids Research
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the adjacent 5′TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex on these transcripts. mTORC1 controls TOP mRNA translation via LARP1, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33c6796172e37713402ce67f761c56
https://pure.au.dk/portal/da/publications/mtorc1-promotes-top-mrna-translation-through-sitespecific-phosphorylation-of-larp1(22c98d47-3e1b-4d0c-97c9-0775991da752).html
https://pure.au.dk/portal/da/publications/mtorc1-promotes-top-mrna-translation-through-sitespecific-phosphorylation-of-larp1(22c98d47-3e1b-4d0c-97c9-0775991da752).html
Autor:
John R P, Knight, Constantinos, Alexandrou, George L, Skalka, Nikola, Vlahov, Kathryn, Pennel, Leah, Officer, Ana, Teodosio, Georgios, Kanellos, David M, Gay, Sebastian, May-Wilson, Ewan M, Smith, Arafath K, Najumudeen, Kathryn, Gilroy, Rachel A, Ridgway, Dustin J, Flanagan, Rachael C L, Smith, Laura, McDonald, Craig, MacKay, Anne, Cheasty, Kerri, McArthur, Emma, Stanway, Joshua D, Leach, Rene, Jackstadt, Joseph A, Waldron, Andrew D, Campbell, Georgios, Vlachogiannis, Nicola, Valeri, Kevin M, Haigis, Nahum, Sonenberg, Christopher G, Proud, Neil P, Jones, Martin E, Swarbrick, Heather J, McKinnon, William J, Faller, John, Le Quesne, Joanne, Edwards, Anne E, Willis, Martin, Bushell, Owen J, Sansom
Publikováno v:
Cancer Discov
KRAS-mutant colorectal cancers (CRC) are resistant to therapeutics, presenting a significant problem for ~40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant CRC. Using Kras-mutant mou
Autor:
Xu-Dong Wang, Christian Kroun Damgaard, Bruno D. Fonseca, An-Dao Yang, Marius R. Niklaus, Huy-Dung Hoang, Jian-Jun Jia, Christopher Dajadian, Tyson E. Graber, Jaclyn Hearnden, Andrea J. Berman, Ewan M. Smith, Tommy Alain, Giovanna Celucci, Roberta Pointet, Roni M. Lahr, Anne Kruse Hollensen, Izabella A. Pena, Yonghao Yu
The mammalian target of rapamycin complex 1 (mTORC1) controls critical cellular functions such as protein synthesis, lipid metabolism, protein turnover and ribosome biogenesis through the phosphorylation of multiple substrates. In this study, we exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cf74fb164b18b878bb43ff28efbea6
https://doi.org/10.1101/491274
https://doi.org/10.1101/491274
Autor:
Aldo S. Bader, Wei-Ting Lu, Michal Malewicz, Ania Wilczynska, Robert A Baldock, Ewan M. Smith, Martin Bushell, Ben R Hawley, George Skalka, Felicity Z. Watts
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood. Here, we show that miRNA biogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fe86a8f722e28e73e39fe13472c257
https://eprints.glos.ac.uk/9779/8/9779-Baldock-(2018)-Drosha-drives-the-formation-of-DNARNA-hybrids.pdf
https://eprints.glos.ac.uk/9779/8/9779-Baldock-(2018)-Drosha-drives-the-formation-of-DNARNA-hybrids.pdf
Publikováno v:
Seminars in Cell & Developmental Biology. 36:102-112
Control of translation allows for the production of stoichiometric levels of each protein in the cell. Attaining such a level of fine-tuned regulation of protein production requires the coordinated temporal and spatial control of numerous cellular si