Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Ewan J. McGhee"'
Autor:
Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung
Publikováno v:
European Urology Open Science, Vol 29, Iss , Pp 19-29 (2021)
Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively. Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis. Design, setting, and participants
Externí odkaz:
https://doaj.org/article/ba12c3a2a624488381047889f1ca7d08
Autor:
Juliana B. Candido, Jennifer P. Morton, Peter Bailey, Andrew D. Campbell, Saadia A. Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J. McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T.R. Jeffry Evans, Colin Nixon, Duncan I. Jodrell, Robert W. Wilkinson, Andrew V. Biankin, Simon T. Barry, Frances R. Balkwill, Owen J. Sansom
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1448-1460 (2018)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the d
Externí odkaz:
https://doaj.org/article/45c8c19d20b94803a6045e1c8286f6ed
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James R.W. Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian M.W. Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi C.E. Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://doaj.org/article/c83a8ae4b29e4df59cdaacb8bc5a5802
Autor:
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 152-167 (2016)
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent me
Externí odkaz:
https://doaj.org/article/df26cad288c04a3b996446d05fb3fd9a
The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues
Autor:
Anna-Karin E. Johnsson, Yanfeng Dai, Max Nobis, Martin J. Baker, Ewan J. McGhee, Simon Walker, Juliane P. Schwarz, Shereen Kadir, Jennifer P. Morton, Kevin B. Myant, David J. Huels, Anne Segonds-Pichon, Owen J. Sansom, Kurt I. Anderson, Paul Timpson, Heidi C.E. Welch
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 1153-1164 (2014)
The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific cell morphologies and responses. Here, we have generated a mouse strain, Rac-FRET, which ub
Externí odkaz:
https://doaj.org/article/8bdba94a3f9d43c791b34b84ce9c7d0a
Autor:
Nicola Rath, Jennifer P Morton, Linda Julian, Lena Helbig, Shereen Kadir, Ewan J McGhee, Kurt I Anderson, Gabriela Kalna, Margaret Mullin, Andreia V Pinho, Ilse Rooman, Michael S Samuel, Michael F Olson
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 2, Pp 198-218 (2016)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in
Externí odkaz:
https://doaj.org/article/965beffc5d8b4fb09500eba6469b356a
Autor:
Kurt I. Anderson, Paul Timpson, Owen J. Sansom, Yingxiao Wang, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, T.R. Jeffry Evans, Lynn C. McGarry, Andrew D. Campbell, Mike Edward, Jean Quinn, Saadia A. Karim, Juliane P. Schwarz, Jennifer P. Morton, Ewan J. McGhee, Max Nobis
Supplementary Movie 5 - WMV file 1818K, Representative maximum projection SHG image of fibrillar collagen I used for GLCM analysis, plus 10 �M cylopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95a403c72d2a1f71170e3ff36fd47a2
https://doi.org/10.1158/0008-5472.22394526.v1
https://doi.org/10.1158/0008-5472.22394526.v1
Autor:
Kurt I. Anderson, Paul Timpson, Owen J. Sansom, Yingxiao Wang, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, T.R. Jeffry Evans, Lynn C. McGarry, Andrew D. Campbell, Mike Edward, Jean Quinn, Saadia A. Karim, Juliane P. Schwarz, Jennifer P. Morton, Ewan J. McGhee, Max Nobis
Supplementary Figure S5 - PDF file 1864K, Summary of FLIM-FRET intravital imaging as a pre-clinical tool for the drug discovery process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b110feda8fc64a20d94deb94a597588
https://doi.org/10.1158/0008-5472.22394550
https://doi.org/10.1158/0008-5472.22394550
Autor:
Kurt I. Anderson, Paul Timpson, Owen J. Sansom, Yingxiao Wang, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, T.R. Jeffry Evans, Lynn C. McGarry, Andrew D. Campbell, Mike Edward, Jean Quinn, Saadia A. Karim, Juliane P. Schwarz, Jennifer P. Morton, Ewan J. McGhee, Max Nobis
Supplementary Movie 1 - WMV file 4865K, Mutant p53R172H PDACs expressing Src biosensor (green) on organotypic assay with SHG signal from ECM components (purple), interacting with fibroblasts (red) during invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf160f23303dd606a2b319e159cb1f
https://doi.org/10.1158/0008-5472.22394541
https://doi.org/10.1158/0008-5472.22394541
Autor:
Kurt I. Anderson, Paul Timpson, Owen J. Sansom, Yingxiao Wang, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, T.R. Jeffry Evans, Lynn C. McGarry, Andrew D. Campbell, Mike Edward, Jean Quinn, Saadia A. Karim, Juliane P. Schwarz, Jennifer P. Morton, Ewan J. McGhee, Max Nobis
Supplementary Figure and Movie Legends�- PDF file 97K, Legend to Supplemental Movies 1-5 and Supplemental Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a939e0e3b6823c9ab433292460de6e2
https://doi.org/10.1158/0008-5472.22394547
https://doi.org/10.1158/0008-5472.22394547