Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ewan D. Fowler"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1805 (2019)
Pulmonary arterial hypertension (PAH) results in hypertrophic remodeling of the right ventricle (RV) to overcome increased pulmonary pressure. This increases the O2 consumption of the myocardium, and without a concomitant increase in energy generatio
Externí odkaz:
https://doaj.org/article/f6612f7b75594d1c9fc90dc89f6412db
Autor:
Ewan D. Fowler, Nan Wang, Melanie J. Hezzell, Guillaume Chanoit, Jules C. Hancox, Mark B. Cannell
Publikováno v:
Fowler, E D, Wang, N, Hezzell, M J, Chanoit, G P A, Hancox, J C & Cannell, M B 2022, ' Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes ', Journal of Molecular and Cellular Cardiology, vol. 172, pp. 52-62 . https://doi.org/10.1016/j.yjmcc.2022.07.009
Loss of ventricular action potential (AP) early phase 1 repolarization may contribute to the impaired Ca 2+ release and increased risk of sudden cardiac death in heart failure. Therefore, restoring AP phase 1 by augmenting the fast transient outward
Autor:
Ewan D, Fowler, Nan, Wang, Melanie J, Hezzell, Guillaume, Chanoit, Jules C, Hancox, Mark B, Cannell
Publikováno v:
Journal of molecular and cellular cardiology. 172
Loss of ventricular action potential (AP) early phase 1 repolarization may contribute to the impaired Ca
Publikováno v:
Wang, N, Dries, E, Fowler, E D, Harmer, S C, Hancox, J C & Cannell, M B 2021, ' Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene ', Journal of Molecular and Cellular Cardiology, vol. 164, pp. 29-41 . https://doi.org/10.1016/j.yjmcc.2021.11.004
The fast transient outward potassium current (Ito,f) plays a key role in phase 1 repolarization of the human cardiac action potential (AP) and its reduction in heart failure (HF) contributes to the loss of contractility. Therefore, restoring Ito,f mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5ca7ed2fb95d73d98b22469c4bae5e
https://research-information.bris.ac.uk/ws/files/304888323/1_s2.0_S0022282821002194_main_2.pdf
https://research-information.bris.ac.uk/ws/files/304888323/1_s2.0_S0022282821002194_main_2.pdf
Autor:
Ewan D. Fowler, Deborah Primrose, Karen McGlynn, John Wilson, Ole J. Kemi, Rachel Smirthwaite
Background: High-intensity interval training (HIIT) with interspersing active recovery is an effective mode of exercise training in cohorts ranging from athletes to patients. Here, we assessed the intensity-dependence of the intervals and active reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4f2e8a928845d25bda0575eb82cd4d
https://eprints.gla.ac.uk/183667/1/183667.pdf
https://eprints.gla.ac.uk/183667/1/183667.pdf
Publikováno v:
Biophysical Journal. 118:569a
Autor:
Olivier Bernus, Ewan D. Fowler, Ed White, Rachel Stones, Olivier Cazorla, David A. Saint, Matthew E. L. Hardy, Alan P. Benson, Mark J. Drinkhill, David Benoist
Publikováno v:
Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, 2014, 115 (2-3), pp.162-172. ⟨10.1016/j.pbiomolbio.2014.06.008⟩
Progress in Biophysics and Molecular Biology, Elsevier, 2014, 115 (2-3), pp.162-172. ⟨10.1016/j.pbiomolbio.2014.06.008⟩
Progress in Biophysics and Molecular Biology, 2014, 115 (2-3), pp.162-172. ⟨10.1016/j.pbiomolbio.2014.06.008⟩
Progress in Biophysics and Molecular Biology, Elsevier, 2014, 115 (2-3), pp.162-172. ⟨10.1016/j.pbiomolbio.2014.06.008⟩
International audience; We demonstrate the synergistic benefits of using multiple technologies to investigate complex multi-scale biological responses. The combination of reductionist and integrative methodologies can reveal novel insights into mecha
Publikováno v:
Biophysical Journal. 114:289a
Publikováno v:
LOCUS Repositório Institucional da UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
Universidade Federal de Viçosa (UFV)
instacron:UFV
Increased physical activity is recommended for the general population and for patients with many diseases because of its health benefits but can be contraindicated if it is thought to be a risk for serious cardiovascular events. One such condition is
Autor:
Jil C. Tardiff, Ger J.M. Stienen, Ewan D. Fowler, Diederik W. D. Kuster, Ed White, Mark T. McConnell, Aref Najafi, Ilse A. E. Bollen, Rob C. I. Wüst, Michiel Helmes, Vasco Sequeira, Cris dos Remedios, Jolanda van der Velden
Publikováno v:
Sequeira Oliveira, V, Najafi, A, McConnell, M, Fowler, E D, Bollen, A E, Wüst, R C I, dos Remedios, C, Helmes, M H B, White, E, Stienen, G J M, Tardiff, J, Kuster, D W D & van der Velden, J 2015, ' Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness ', Journal of Physiology-London, vol. 593, no. 17, pp. 3899-3916 . https://doi.org/10.1113/JP270354
Journal of Physiology-London, 593(17), 3899-3916. Wiley-Blackwell
Journal of physiology, 593(17), 3899-3916. Wiley-Blackwell
Journal of Physiology-London, 593(17), 3899-3916. Wiley-Blackwell
Journal of physiology, 593(17), 3899-3916. Wiley-Blackwell
Diastolic dysfunction in heart failure patients is evident from stiffening of the passive properties of the ventricular wall. Increased actomyosin interactions may significantly limit diastolic capacity, however, direct evidence is absent. From exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f52a8bff442aaa324e2c91899b96eb
https://research.vumc.nl/en/publications/79f9ba0c-bd38-4d8a-8d0c-c41c6fbb787f
https://research.vumc.nl/en/publications/79f9ba0c-bd38-4d8a-8d0c-c41c6fbb787f