Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ewan A. Ross"'
Autor:
Ewan A. Ross, Lesley-Anne Turner, Hannah Donnelly, Anwer Saeed, Monica P. Tsimbouri, Karl V. Burgess, Gavin Blackburn, Vineetha Jayawarna, Yinbo Xiao, Mariana A. G. Oliva, Jennifer Willis, Jaspreet Bansal, Paul Reynolds, Julia A. Wells, Joanne Mountford, Massimo Vassalli, Nikolaj Gadegaard, Richard O. C. Oreffo, Manuel Salmeron-Sanchez, Matthew J. Dalby
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Mesenchymal Stromal Cells are hard to expand whilst retaining immunomodulatory properties due to spontaneous differentiation and ageing in culture. Here, the authors describe a mechanotransductive link between metabolism and functional activity and i
Externí odkaz:
https://doaj.org/article/3492f3b33d7a422a8a602e5982a536a0
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation. In this review, we will compile and interpret recent findings on the plasticity of macrophages and how these cells contribute to the devel
Externí odkaz:
https://doaj.org/article/0a1a06d872894547a9846b4db877a78f
Autor:
Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe, Ewan A. Ross, Dalya R. Rosner, John D. O’Neil, Andrew R. Clark
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, includin
Externí odkaz:
https://doaj.org/article/e7a8d022846a45f791a2ff0161e3b82b
Autor:
Ian R. Henderson, David R. Withers, Saeeda Bobat, Nick D. Jones, Adam F. Cunningham, Charlotte N. Cook, Amanda E. Rossiter, Adriana Flores-Langarica, Steve P. Watson, Nonantzin Beristain-Covarrubias, Jessica L. Rooke, Ewan A. Ross, Kyoko Nakamura, Alicia Garcia-Gimenez, Ruby R Persaud, Ruth E. Coughlan, Jessica Hitchcock, Marisol Perez-Toledo, Edith Marcial-Juarez, Sian E Jossi, William M Channell
Publikováno v:
The Journal of Immunology Author Choice
Key Points T-bet−/− mice induce significant IFN-γ responses after Salmonella infection. Infection of T-bet−/− mice enhances nonprotective Th17/neutrophil responses. iNOS+ granulomas that fail to constrain Salmonella are induced in T-bet−/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f935dc3ac3b79d81de1e6f0bd0639da9
http://europepmc.org/articles/PMC7372318
http://europepmc.org/articles/PMC7372318
Autor:
Saeeda Bobat, Matthew Darby, Dunja Mrdjen, Charlotte Cook, Erin Logan, Jennifer Auret, Elizabeth Jones, Corinna Schnoeller, Adriana Flores-Langarica, Ewan A Ross, Alykhan Vira, Constantino López-Macías, Ian R Henderson, James Alexander, Frank Brombacher, William G Horsnell, Adam F Cunningham
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3341 (2014)
BACKGROUND:The impact of exposure to multiple pathogens concurrently or consecutively on immune function is unclear. Here, immune responses induced by combinations of the bacterium Salmonella Typhimurium (STm) and the helminth Nippostrongylus brasili
Externí odkaz:
https://doaj.org/article/86e5dfc92ec241138ef83a6d287f1e10
Autor:
Ewan A Ross, Sylvie Freeman, Yan Zhao, Tarvinder S Dhanjal, Emma J Ross, Sian Lax, Zubair Ahmed, Tie Zheng Hou, Neena Kalia, Stuart Egginton, Gerard Nash, Steve P Watson, Jon Frampton, Christopher D Buckley
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2338 (2008)
Although the expression of PECAM-1 (CD31) on vascular and haematopoietic cells within the bone marrow microenvironment has been recognized for some time, its physiological role within this niche remains unexplored. In this study we show that PECAM-1
Externí odkaz:
https://doaj.org/article/91b3a40c108145fc9c4cbc188637a376
Autor:
Manuel Salmerón-Sánchez, Paul M. Reynolds, Joanne C. Mountford, Karl Burgess, Anwar Saeed, Nikolaj Gadegaard, Julia Wells, Richard O.C. Oreffo, Gavin Blackburn, Matthew J. Dalby, L Turner, Ewan A. Ross
Mesenchymal stems cells (MSCs) are multipotent stem cells that are immunosuppressive and thus of considerable therapeutic potential in transplant operations. However, MSCs rapidly differentiate once in culture, making their large-scale expansion for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4440a436dd850d4d7f1971a3d626a1
Autor:
Guillaume E. Desanti, Andrew R. Clark, James M. Brown, Atif Saghir, Ewan A. Ross, Amy J. Naylor, Ela Claridge, Andrew Filer, Christopher D. Buckley
Rheumatoid arthritis (RA) is an autoimmune disease in which chronic inflammation of the synovial joints can lead to destruction of cartilage and bone. Pre-clinical studies attempt to uncover the underlying causes by emulating the disease in genetical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d99d38de28a4010c078c78c8484661
https://publications.aston.ac.uk/id/eprint/40190/1/Detection_and_characterisation.pdf
https://publications.aston.ac.uk/id/eprint/40190/1/Detection_and_characterisation.pdf
Autor:
Robert A. Kingsley, Jeremy H. Lakey, Ian R. Henderson, Ewan A. Ross, Adriana Flores-Langarica, Calman A. MacLennan, Jessica Hitchcock, Kai-Michael Toellner, Laura B. Martin, Jennifer L. Marshall, Adam F. Cunningham, Constantino López-Macías, Gordon Dougan, Ian C. M. MacLennan
Publikováno v:
The Journal of Immunology. 189:5527-5532
Vaccination with purified capsular polysaccharide Vi Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy is not clearly established. In this study, we have characterized the B cell response to this vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af962d57f92b69396b441b3f8794e2c
https://doi.org/10.4049/jimmunol.1103166
https://doi.org/10.4049/jimmunol.1103166
Autor:
Charlotte N. Cook, Ian R. Henderson, Adam F. Cunningham, Jonathan Jobanputra, Adriana Flores-Langarica, Shizuo Akira, Saeeda Bobat, Ruth E. Coughlan, Jessica Hitchcock, Jennifer L. Marshall, Satoshi Uematsu, Ewan A. Ross
Publikováno v:
The Journal of Immunology. 189:5745-5754
Mucosal immunity is poorly activated after systemic immunization with protein Ags. Nevertheless, induction of mucosal immunity in such a manner would be an attractive and simple way to overcome the intrinsic difficulties in delivering Ag to such site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99c9d720db1cabb84b2e34272acf914
https://doi.org/10.4049/jimmunol.1202283
https://doi.org/10.4049/jimmunol.1202283