Supplementary Table 1 from Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors

Autor: John C. Reed, Ewan Brown, Imtiaz A. Mawji, Debbie Gurfinkel, Marina Konopleva, Gregory R. Pond, Maurizio Pellecchia, Marcela Gronda, Rose Hurren, Michael P. Thomas, Aaron D. Schimmer

Supplementary Table 1 from Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166d37258663186323d956a446da17c9
https://doi.org/10.1158/0008-5472.22366161

Data from Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors

Autor: John C. Reed, Ewan Brown, Imtiaz A. Mawji, Debbie Gurfinkel, Marina Konopleva, Gregory R. Pond, Maurizio Pellecchia, Marcela Gronda, Rose Hurren, Michael P. Thomas, Aaron D. Schimmer

Two major pathways for apoptosis have been identified, involving either mitochondria (intrinsic) or tumor necrosis factor (TNF)-family death receptors (extrinsic) as initiators of caspase protease activation and cell death. Because tumor resistance t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee8640ba7370a26b8fe891619ec472c
https://doi.org/10.1158/0008-5472.c.6495015.v1

Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial

Autor: Janet Graham, Mahesh K. B. Parmar, Emma Yates, Tim Maughan, Jenny F. Seligmann, Louise Brown, David Fisher, Kai-Keen Shiu, Fiona Collinson, Ewan Brown, Philip Quirke, Stephen Falk, Richard H. Wilson, Susan D. Richman, Gary Middleton, Harpreet Wasan, Richard Kaplan, Richard Adams, Rachel Butler, Matthew T. Seymour, Leslie Samuel

Publikováno v: Journal of Clinical Oncology. 39:3693-3704

PURPOSE Despite extensive randomized evidence supporting the use of treatment breaks in metastatic colorectal cancer (mCRC), they are not universally offered to patients despite improvements in quality of life without detriment to overall survival (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8613af3a09ee38d5f24c3bcc6918ce
https://doi.org/10.1200/jco.21.01436

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC):long-term results of a multicentre, randomised, controlled, phase 3 trial

Autor: Marjorie Tomlinson, Juan W. Valle, Meg Finch-Jones, O. James Garden, S Pugh, Tamas Hickish, Joanne Hornbuckle, Sharadah Essapen, Raaj K. Praseedom, Chan Ton, Marcia Hall, Alison Brewster, Sarah Smith, A Mayer, Nariman Karanjia, Stephen Falk, Nagappan Kumar, Mark A. Hill, Stephen Fenwick, Tim Maughan, John Bridgewater, Alison Brown, Sherif Raouf, Andrea Corkhill, Amy Whitehead, Vanessa Potter, Charlotte Rees, Tom Diamond, Ajith K. Siriwardena, David J. Smith, Susan Cleator, Charles Wilson, Sarah Slater, John N. Primrose, David Cunningham, Gareth Griffiths, Hassan Malik, Nasim Ali, Alex Allen, Christopher Baughan, Satya Bhattacharya, Timothy Iveson, Charles Lowdell, Satvinder Mudan, Brian R. Davidson, Louise Stanton, Paul Ross, Luke Nolan, Iain Cameron, Ann O'Callaghan, Robert J. Thomas, Ewan Brown, Tom Maishman, Anne Moody, Sally Clive, Clare Barlow, Mike Radford, Nua Chan Ton, Georgina Walker, David Tsang, Derek A. O'Reilly, Alaaeldin Shablack, Colin Purcell, Mark Peterson, Zina Eminton, Myrddin Rees, Nigel Heaton, Jane Mellor

Publikováno v: New EPOC investigators 2020, ' Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC) : long-term results of a multicentre, randomised, controlled, phase 3 trial ', The Lancet Oncology, vol. 21, no. 3, pp. 398-411 . https://doi.org/10.1016/S1470-2045(19)30798-3
The Lancet. Oncology

Background: The interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction in progression-free survival in patients allocated to cetuximab plus chemotherapy compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1626d37868998ab4d8cd96edfc217e80
https://doi.org/10.1016/S1470-2045(19)30798-3

431P The FOCUS4-N trial results and individual patient data meta-analysis (IPDM) of maintenance therapy versus active monitoring for patients with metastatic colorectal cancer (mCRC)

Autor: Richard Kaplan, F. Collinson, Tim Maughan, Richard H. Wilson, S. Richman, E. Yates, Philip Quirke, Ewan Brown, Matthew T. Seymour, Louise Brown, David Fisher, R. Butler, J. Seligmann, Janet Graham, Richard Adams, S Falk

Publikováno v: Annals of Oncology. 32:S549

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7064eb0e66c92d55857d4878d91482d4
https://doi.org/10.1016/j.annonc.2021.08.952