Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Autor: Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)

Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-

Externí odkaz: https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06

PS-B09-4: SHORTER LEUKOCYTE TELOMERE LENGTH AS AN EARLY INDICATOR FOR CHRONIC KIDNEY DISEASE IN HYPERTENSIVE PATIENTS

Autor: Olutope Arinola Akinnibosun, James Eales, Huy Nguyen, Pawel Bogdanski, Ewa Zukowska Szczechowska, Matthew Denniff, Maciej Tomaszewski, Fadi Charchar

Publikováno v: Journal of Hypertension. 41:e377-e378

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cec14f4c470eea3a22b498027da7533d
https://doi.org/10.1097/01.hjh.0000916672.28375.c5

PS-BPB06-5: URINARY CELL TRANSCRIPTOMICS: A NON-INVASIVE EXPRESSION READOUT OF KIDNEY GENES OF RELEVANCE TO HYPERTENSION

Autor: James M Eales, Pawel Bogdanski, Wojciech Wystrychowski, Ewa Zukowska Szczechowska, Joanna Zywiec, Adrian S Woolf, Nilesh J Samani, Bernard Keavney, Fadi J Charchar, Maciej Tomaszewski

Publikováno v: Journal of Hypertension. 41:e279

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3e32563dfe1c31110966034c9d44059
https://doi.org/10.1097/01.hjh.0000915588.95718.87

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney

Autor: Ingrid Wise, Bradley Godfrey, Raymond T. O'Keefe, Mikael Ekholm, Wojciech Wystrychowski, Pasquale Maffia, Matthias Kretzler, Sushant Saluja, James Eales, Artur Akbarov, Christopher Finan, Maciej Tomaszewski, Monika Szulińska, Gosia Trynka, Matthew Denniff, Sanjeev Pramanik, Ewa Zukowska-Szczechowska, Bernard Keavney, Andrew P. Morris, Yusif Shakanti, Sandesh Chopade, John Bowes, Eddie Cano-Gamez, Huw B. Thomas, Matthew G. Sampson, Xiaoguang Xu, Evangelos Evangelou, Paweł Bogdański, Priscilla R. Prestes, Stephen Eyre, Xiao Jiang, David Talavera, Fadi J. Charchar, Hui Guo, Andrzej Antczak, Joanna Zywiec, Nilesh J. Samani, Alicja Nazgiewicz, Michelle T. McNulty, Adrian S. Woolf, Robert Król, Tomasz J. Guzik, Jason Brown, Carlo Berzuini, Mahan Salehi, Maciej Glyda, Aroon D. Hingorani, Felix Eichinger, Mark J. Caulfield

Publikováno v: Nature Genetics
Eales, J, Jiang, X, Xu, X, Saluja, S, Akbarov, A, Cano-Gomez, E, McNulty, M T, Finan, C, Guo, H, Wystrychowski, W, Szulinska, M, Thomas, H, Pramanik, S, Chopade, S, Prestes, P R, Wise, I, Evangelou, E, Salehi, M, Shakanti, Y, Ekholm, M, Denniff, M, Nazgiewicz, A, Eichinger, F, Godfrey, B, Antczak, A, Glyda, M, Król, R, Eyre, S, Brown, J, Berzuini, C, Bowes, J, Caulfield, M, Zukowska-Szczechowska, E, Zywiec, J, Bogdanski, P, Kretzler, M, Woolf, A S, Talavera, D, Keavney, B, Maffia, P, Guzik, T J, O'Keefe, R, Trynka, G, Samani, N J, Hingorani, A D, Sampson, M G, Morris, A P, Charchar, F J, Tomaszewski, M & Morris, A 2021, ' Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney ', Nature Genetics, vol. 53, no. 5, pp. 630–637 . https://doi.org/10.1038/s41588-021-00835-w

The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We integrated g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2155ee0f1aed73a8a73ac6151d01c4a

Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors.

Autor: Joshua Denham, Christopher P Nelson, Brendan J O'Brien, Scott A Nankervis, Matthew Denniff, Jack T Harvey, Francine Z Marques, Veryan Codd, Ewa Zukowska-Szczechowska, Nilesh J Samani, Maciej Tomaszewski, Fadi J Charchar

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69377 (2013)

Telomere length is recognized as a marker of biological age, and shorter mean leukocyte telomere length is associated with increased risk of cardiovascular disease. It is unclear whether repeated exposure to ultra-endurance aerobic exercise is benefi

Externí odkaz: https://doaj.org/article/6d20c6c59e4845efb66344ae455619a4