Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ewa Wasilewski"'
Autor:
Amr F. Hamour, John JW. Lee, Ewa Wasilewski, Eric Monteiro, John M. Lee, Allan Vescan, Lakshmi P. Kotra
Publikováno v:
Journal of Otolaryngology - Head and Neck Surgery, Vol 52, Iss 1, Pp 1-8 (2023)
Abstract Background Chronic rhinosinusitis (CRS) is a complex inflammatory disease of the sinonasal tract. To understand this disease entity and develop targeted treatments, a reproducible animal model is paramount. Aims/objectives To optimize a muri
Externí odkaz:
https://doaj.org/article/50b8b4b6903746f49dc689ef3991f683
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 6091-6103 (2017)
Externí odkaz:
https://doaj.org/article/1333ca876ab849b5a64293b5b1e72ef3
Autor:
Prabjit Ajrawat, Yi Yang, Ewa Wasilewski, Timothy Leroux, Karim S. Ladha, Anuj Bhatia, Mandeep Singh, Sonalben Thaker, Mohit Kapoor, Andrea D. Furlan, Lakshmi P. Kotra, Hance Clarke
Publikováno v:
Cannabis and Cannabinoid Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45c085155d26416d493de87d2b14b41
https://doi.org/10.1089/can.2022.0143
https://doi.org/10.1089/can.2022.0143
Autor:
Lakshmi P. Kotra, Ewa Wasilewski, Shannon E. Dunn, Angelica M. Bello, Elizabeth J. Curiel Tejeda, Adam Koebel
Publikováno v:
Journal of Medicinal Chemistry. 60:8876-8887
Peptidyl arginine deiminases have been shown to be hyperactive in neurodegenerative diseases including multiple sclerosis. An α-amino acid-based core structure, derived from a hydantoin core, with unique heterocycles on the side chains were synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0185780e7119f983456ed1599bb131e
https://doi.org/10.1021/acs.jmedchem.7b01102
https://doi.org/10.1021/acs.jmedchem.7b01102
Publikováno v:
ACS Omega
ACS Omega, Vol 2, Iss 9, Pp 6091-6103 (2017)
ACS Omega, Vol 2, Iss 9, Pp 6091-6103 (2017)
Medical cannabis has been legally available for patients in a number of countries. Licensed producers produce a variety of cannabis strains with different concentrations of phytocannabinoids. Phytocannabinoids in medical cannabis are decarboxylated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb000d38cd1b8226933dfe3e93f0bce
http://europepmc.org/articles/PMC6044620
http://europepmc.org/articles/PMC6044620
Autor:
Angelica M. Bello, Amit Sarswat, Andrew V. Caprariello, Chithra M. Muthuramu, Lakshmi P. Kotra, Sai Kumar Chakka, Ewa Wasilewski, Shannon E. Dunn, Peter K. Stys
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2643-2656
Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c87f1213d1dffc54c5b327fc1a494
https://doi.org/10.1016/j.bmc.2017.03.006
https://doi.org/10.1016/j.bmc.2017.03.006
Publikováno v:
Springer Proceedings in Mathematics & Statistics ISBN: 9783319077543
The complex process to develop a successful therapeutic drug is lengthy and costly. In order to accelerate this process, molecular modeling has become a key component of drug design. Methods used in computational chemistry vary from Ab initio quantum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0d42c0201cb4b428cf2eaad83551e7
https://doi.org/10.1007/978-3-319-07755-0_6
https://doi.org/10.1007/978-3-319-07755-0_6
Autor:
Lakshmi P. Kotra, Lianhu Wei, Angelica M. Bello, Mario A. Moscarello, Ewa Wasilewski, Sai Kumar Chakka
Publikováno v:
Journal of medicinal chemistry. 56(4)
In multiple sclerosis (MS), myelin basic protein (MBP), critical for the maintenance of myelin compaction and protecting against degradation, is known to contain concentrations of the noncoded amino acid, "citrulline", in abnormal proportions. Peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f53a3c10ef1634787157cb9d728075
https://pubmed.ncbi.nlm.nih.gov/23421315
https://pubmed.ncbi.nlm.nih.gov/23421315
Protein arginine deiminases (PADs) are involved in a number of cellular pathways, and they catalyze the transformation of peptidyl arginine residue into a citrulline as part of post-translational modifications. To understand ligand preferences, a gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb5460edfc48282f2632de7aa8878bd
https://europepmc.org/articles/PMC4027443/
https://europepmc.org/articles/PMC4027443/