Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ewa S Pilka"'
Autor:
Li Fei, SiSi Tian, Ruth Moysey, Mihaela Misca, John J Barker, Myron A Smith, Paul A McEwan, Ewa S Pilka, Lauren Crawley, Tom Evans, Dapeng Sun
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117470 (2015)
A novel exonuclease, designated as MszExo I, was cloned from Methylocaldum szegediense, a moderately thermophilic methanotroph. It specifically digests single-stranded DNA in the 3' to 5' direction. The protein is composed of 479 amino acids, and it
Externí odkaz:
https://doaj.org/article/e2309bf0477746b894c141e3104207ab
Autor:
Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J Maloney, Ewa S Pilka, Minghua Wang, Udo Oppermann, Tom D Heightman, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13719 (2010)
15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1.1.141) is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation. The anabolic pathways of prostaglandins, especially with respect to re
Externí odkaz:
https://doaj.org/article/da1276c059c2465cb83ff8f287ef16f9
Autor:
Ewa S Pilka, Frank H Niesen, Wen Hwa Lee, Yasser El-Hawari, James E Dunford, Grazyna Kochan, Vladimir Wsol, Hans-Joerg Martin, Edmund Maser, Udo Oppermann
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7113 (2009)
Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to re
Externí odkaz:
https://doaj.org/article/9952e0bf45994e3c9d214efdae5d684b
Publikováno v:
Drug Discovery Today. 26:442-454
Serine protease inhibitors (serpins) are a large family of proteins that regulate and control crucial physiological processes, such as inflammation, coagulation, thrombosis and thrombolysis, and immune responses. The extraordinary impact that these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4cce6adaa74ecf8be96f00db75c19e
https://doi.org/10.1016/j.drudis.2020.11.012
https://doi.org/10.1016/j.drudis.2020.11.012
Publikováno v:
Trends in Pharmacological Sciences
Journal of Autoimmunity
Journal of Autoimmunity
Background Animal models and few clinical reports suggest the involvement of the complement system in the onset of severe manifestations of coronavirus disease-2019 (COVID-19). However, complement contribution to endotheliopathy and hypercoagulabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a6b5ea75e8c3b1393b58cbfcb68050
https://doi.org/10.1016/j.tips.2021.03.006
https://doi.org/10.1016/j.tips.2021.03.006
Autor:
Etienne De Braekeleer, Patrick Guest, Maria Eleftheriou, Georgia Tsagkogeorga, Ewa S. Pilka, Nerea Irigoyen, Malgorzata Gozdecka, Tony Kouzarides, Binje Vick, Andrew J. Bannister, Richard Fosbeary, Mark Albertella, Justyna Rak, Alan G. Hendrick, Irmela Jeremias, Dan Leggate, Demetrios Aspris, George S. Vassiliou, Eliza Yankova, Oliver Rausch, Natalie A. Webster, Konstantinos Tzelepis, Byron Andrews, João Lopes Dias, Wesley Blackaby
Publikováno v:
Nature 593, 597-601 (2021)
Nature
Nature
N6-methyladenosine (m6A) is an abundant internal RNA modification1,2 that is catalysed predominantly by the METTL3–METTL14 methyltransferase complex3,4. The m6A methyltransferase METTL3 has been linked to the initiation and maintenance of acute mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d210f07dd025da467c48c4ac96a2015
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61877
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=61877
Autor:
Kathryn L. Kavanagh, T. Krojer, João R. C. Muniz, S.S. Ng, Michael A. McDonough, Rok Sekirnik, Nadia J. Kershaw, Wei Ge, Aidan J. Doherty, Christopher J. Schofield, Chia-hua Ho, Ewa S. Pilka, Ian J. Clifton, Rasheduzzaman Chowdhury, Udo Oppermann, Gavin C. Fox, M. Vollmar, Claire Phillips, Frank von Delft, Nigel C. Brissett
Publikováno v:
Nature
Crystal structures of human and prokaryotic ribosomal oxygenases reported here, with and without their ribosomal protein substrates, support their assignments as hydroxylases, and provide insights into the evolution of the JmjC-domain-containing hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5419a93034e4f468b7cfd6cd5727ba0d
https://doi.org/10.1038/nature13263
https://doi.org/10.1038/nature13263
Autor:
Opher Gileadi, Udo Oppermann, Kathryn L. Kavanagh, John Offer, S.S. Ng, Michael Sundström, Johanna C. Scheinost, Tomasz Borowski, Michael A. McDonough, Ewa S. Pilka, Benoît M. R. Liénard, Frank von Delft, Pavel Savitsky, James E. Bray, Danica Butler, Christopher J. Schofield, Nathan R. Rose
Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65e65c66328fd56f1cc462b7b2d12a6
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy
Autor:
Paul J. A. Michiels, Kathryn L. Kavanagh, Christian Ludwig, Udo Oppermann, Ulrich L. Günther, Anna Jansson, Ewa S. Pilka, Xiaoqiu Wu
Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide), which exhibits a profound antitumor effect in human cancers when administered together with caricotamide. X-ray structure det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1e539118980438f1f9e1d430e07d96
https://doi.org/10.1021/jm701020f
https://doi.org/10.1021/jm701020f
Autor:
Edmund Maser, Udo Oppermann, Ewa S. Pilka, Michael Kisiela, Hans-Jörg Martin, Yasser El-Hawari, Angelo D. Favia
Publikováno v:
Chemico-Biological Interactions. 178:234-241
Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an important role in the detoxification of xenobiotics bearing a carbonyl group. The two monomeric NADPH-dependent human is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76416a1e20703b42969e7fc34cf55372
https://doi.org/10.1016/j.cbi.2008.11.004
https://doi.org/10.1016/j.cbi.2008.11.004