SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics

Autor: Greg G. Jones, Sibel Sari, Pablo Rodriguez-Viciana, Nicole Hartig, Amandeep Bhamra, Ewa Rejnowicz, Isabel Boned del Río, Benjamin Ringham-Terry, Winnie Lei, Lucy C. Young, Silvia Surinova

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27

Significance The ERK signaling pathway is hyperactivated in a majority of cancers. However, because it mediates myriad physiological responses, the clinical efficacy of current ERK pathway inhibitors has been severely limited by toxicity. This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fc24a24bc8e5b6eeae72bb00d076d9
http://europepmc.org/articles/PMC6613145