Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Ewa Rajpert De-Meyts"'
Autor:
Sofia B. Winge, Niels E. Skakkebaek, Lise Aksglaede, Gülizar Saritaş, Ewa Rajpert-De Meyts, Ellen Goossens, Anders Juul, Kristian Almstrup
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-9 (2024)
Abstract Klinefelter syndrome (47,XXY) causes infertility with a testicular histology comprising two types of Sertoli cell-only tubules, representing mature and immature-like Sertoli cells, and occasionally focal spermatogenesis. Here, we show that t
Externí odkaz:
https://doaj.org/article/213b1e601e994cd09253e3f58a93d4b8
Autor:
Liina Nagirnaja, Alexandra M. Lopes, Wu-Lin Charng, Brian Miller, Rytis Stakaitis, Ieva Golubickaite, Alexandra Stendahl, Tianpengcheng Luan, Corinna Friedrich, Eisa Mahyari, Eloise Fadial, Laura Kasak, Katinka Vigh-Conrad, Manon S. Oud, Miguel J. Xavier, Samuel R. Cheers, Emma R. James, Jingtao Guo, Timothy G. Jenkins, Antoni Riera-Escamilla, Alberto Barros, Filipa Carvalho, Susana Fernandes, João Gonçalves, Christina A. Gurnett, Niels Jørgensen, Davor Jezek, Emily S. Jungheim, Sabine Kliesch, Robert I. McLachlan, Kenan R. Omurtag, Adrian Pilatz, Jay I. Sandlow, James Smith, Michael L. Eisenberg, James M. Hotaling, Keith A. Jarvi, Margus Punab, Ewa Rajpert-De Meyts, Douglas T. Carrell, Csilla Krausz, Maris Laan, Moira K. O’Bryan, Peter N. Schlegel, Frank Tüttelmann, Joris A. Veltman, Kristian Almstrup, Kenneth I. Aston, Donald F. Conrad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The GEMINI consortium sequenced 1,000 cases of idiopathic male infertility and identified a plausible Mendelian cause in 20% of cases. The infertility genes can be grouped by expression pattern, facilitating their interpretation and follow-up.
Externí odkaz:
https://doaj.org/article/d33757f275f346459883626f17daf68f
Autor:
Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats dem
Externí odkaz:
https://doaj.org/article/6faa0696ef594229b30882d592bea05d
Autor:
John Pluta, Louise C. Pyle, Kevin T. Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, Kurt D’Andrea, Kristian Almstrup, Lynn Anson-Cartwright, Javier Benitez, Christopher D. Brown, Stephen Chanock, Chu Chen, Victoria K. Cortessis, Alberto Ferlin, Carlo Foresta, Marija Gamulin, Jourik A. Gietema, Chiara Grasso, Mark H. Greene, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Russ Hauser, Michelle A. T. Hildebrandt, Matthew E. Johnson, Robert Karlsson, Lambertus A. Kiemeney, Davor Lessel, Ragnhild A. Lothe, Jennifer T. Loud, Chey Loveday, Paloma Martin-Gimeno, Coby Meijer, Jérémie Nsengimana, David I. Quinn, Thorunn Rafnar, Shweta Ramdas, Lorenzo Richiardi, Rolf I. Skotheim, Kari Stefansson, Clare Turnbull, David J. Vaughn, Fredrik Wiklund, Xifeng Wu, Daphne Yang, Tongzhang Zheng, Andrew D. Wells, Struan F. A. Grant, Ewa Rajpert-De Meyts, Stephen M. Schwartz, D. Timothy Bishop, Katherine A. McGlynn, Peter A. Kanetsky, Katherine L. Nathanson, The Testicular Cancer Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Testicular germ cell tumors are highly heritable, and the authors present the largest genome association study, identifying 22 novel loci, which account for a third of those identified to date. Implicated pathways include male germ cell development a
Externí odkaz:
https://doaj.org/article/1bc43b27ac0f4b2690a3ddaf9399e619
Autor:
Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts, Anders Juul
Publikováno v:
Endocrine Connections, Vol 7, Iss 3, Pp 1-7 (2018)
Objective: Only a few genetic loci are known to be associated with male pubertal events. The ability of excreting testosterone (T) and other steroids in the urine depends on sulfation and glucuronidation. One of several essential glucuronidases is en
Externí odkaz:
https://doaj.org/article/ea14f088d82c498488954e36b15cc6b3
Autor:
Ewa Rajpert‐De Meyts, Niels Jørgensen, Jørgen Holm Petersen, Kristian Almstrup, Lise Aksglaede, Jakob Lauritsen, Mikael Rørth, Gedske Daugaard, Niels E. Skakkebæk
Publikováno v:
Rajpert-De Meyts, E, Jørgensen, N, Petersen, J H, Almstrup, K, Aksglaede, L, Lauritsen, J, Rørth, M, Daugaard, G & Skakkebaek, N E 2022, ' Optimised detection of germ cell neoplasia in situ in contralateral biopsy reduces the risk of second testis cancer ', BJU International, vol. 130, no. 5, pp. 646-654 . https://doi.org/10.1111/bju.15774
To evaluate whether optimized and standardized diagnostic procedures would improve detection of germ cell neoplasia in situ (GCNIS) in the contralateral testis of patients with testicular germ cell tumour (TGCT) and decrease the rate of metachronous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e6b50438d282039b3ca5e8a7b7cc29
https://doi.org/10.1111/bju.15774
https://doi.org/10.1111/bju.15774
Autor:
Elena Monai, MD, Anders Johansen, MD, PhD, Erik Clasen-Linde, MD, Ewa Rajpert-De Meyts, MD, DMSc, Niels Erik Skakkebæk, MD, DMSc, Katharina M. Main, MD, PhD, Anne Jørgensen, MSc, PhD, Rikke Beck Jensen, MD, PhD
Publikováno v:
AACE Clinical Case Reports, Vol 5, Iss 6, Pp e352-e356 (2019)
ABSTRACT: Objective: Prader-Willi syndrome (PWS) is a rare genetic neuroendocrine disorder characterized by hypotonia, obesity, short stature, and mental retardation. Incomplete or delayed pubertal development as well as premature adrenarche are usua
Externí odkaz:
https://doaj.org/article/53c7c65c90104badb933529081defc0d
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebaek, Peter W. Andrews, Harry D. Moore, Lise Mette Gjerdrum, Søren Brunak, Peter E. Huber, Amir Abdollahi, Christian Schwager, Neil J. Harrison, Ludmila Ruban, Daniel Edsgard, Agnieszka Sierakowska Juncker, Marlene Dalgaard, Kristian Almstrup, Si Brask Sonne
Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547c602239dd7afad5c654a64e4b9bb4
https://doi.org/10.1158/0008-5472.22378791.v1
https://doi.org/10.1158/0008-5472.22378791.v1
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebæk, John E. Nielsen, Wilhelm Ansorge, Christian Schwager, Jonathon Blake, Ute Wirkner, Christina E. Hoei-Hansen, Kristian Almstrup
Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common malignancy of young men. Using genome-wide gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe1450a544f24d7e4fd3a9b8a00e2d
https://doi.org/10.1158/0008-5472.c.6493599
https://doi.org/10.1158/0008-5472.c.6493599
Autor:
Henrik Leffers, Ewa Rajpert-De Meyts, Niels E. Skakkebaek, Peter W. Andrews, Harry D. Moore, Lise Mette Gjerdrum, Søren Brunak, Peter E. Huber, Amir Abdollahi, Christian Schwager, Neil J. Harrison, Ludmila Ruban, Daniel Edsgard, Agnieszka Sierakowska Juncker, Marlene Dalgaard, Kristian Almstrup, Si Brask Sonne
Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. CIS cells were suggested to arise from primordial germ cells or gonocytes. However, direct studies on purified samples of CIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba6d868ef0a942e95de6947729c8e9a
https://doi.org/10.1158/0008-5472.c.6499017.v1
https://doi.org/10.1158/0008-5472.c.6499017.v1