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Akademický článek

An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

Autor: Ewa Przybytkowski, Thomas Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf, Sheida Nabavi

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-16 (2020)

Abstract Background BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The prominent tumor muta

Externí odkaz: https://doaj.org/article/995b17e12f284b2aba40fbf5e46134e0

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Human adipose tissue-derived stromal cells act as functional pericytes in mice and suppress high-glucose-induced proinflammatory activation of bovine retinal endothelial cells

Autor: Marja J. A. van Luyn, Martin C. Harmsen, Ingeborg Klaassen, Genaro A. Paredes-Juarez, Frederick Pfister, Ewa Przybyt, Ghazaleh Hajmousa, Kondaiah Moganti, Guido Krenning, Jeroen Kuipers, Stephanie Busch, Hans-Peter Hammes

Publikováno v: Diabetologia, 61(11), 2371-2385. Springer Verlag
Diabetologia, 61(11), 2371-2385. SPRINGER
Diabetologia

Aims/hypothesis: The immunomodulatory capacity of adipose tissue-derived stromal cells (ASCs) is relevant for next-generation cell therapies that aim to reverse tissue dysfunction such as that caused by diabetes. Pericyte dropout from retinal capilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f5359da13cc4602be973abe6cec7a8
https://doi.org/10.1007/s00125-018-4713-0

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Diet-induced obesity resistance of adult female mice selectively bred for increased wheel-running behavior is reversed by single perinatal exposure to a high-energy diet

Autor: Stefano Guidotti, Anton J.W. Scheurink, Gertjan van Dijk, Ewa Przybyt, Neele Meyer, Martin C. Harmsen, Theodore Garland

Publikováno v: Physiology & Behavior, 157, 246-257. PERGAMON-ELSEVIER SCIENCE LTD

Female mice from independently bred lines previously selected over 50 generations for increased voluntary wheel-running behavior (S1, S2) resist high energy (HE) diet-induced obesity (DIO) at adulthood, even without actual access to running wheels, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519a5cbf5894246b8179d193435511f3
https://doi.org/10.1016/j.physbeh.2016.02.003

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Adipose Tissue-Derived Stromal Cells Inhibit TGF-beta 1-Induced Differentiation of Human Dermal Fibroblasts and Keloid Scar-Derived Fibroblasts in a Paracrine Fashion

Autor: Martin C. Harmsen, Ewa Przybyt, Susan Gibbs, Maroesjka Spiekman, Berend van der Lei, Josee A. Plantinga

Publikováno v: Plastic and Reconstructive Surgery, 134(4), 699-712. LIPPINCOTT WILLIAMS & WILKINS
Spiekman, M, Przybyt, E, Plantinga, J A, Gibbs, S, van der Lei, B & Harmsen, M C 2014, ' Adipose Tissue-Derived Stromal Cells Inhibit TGF-beta 1-Induced Differentiation of Human Dermal Fibroblasts and Keloid Scar-Derived Fibroblasts in a Paracrine Fashion ', Plastic and reconstructive surgery, vol. 134, no. 4, pp. 699-712 . https://doi.org/10.1097/PRS.0000000000000504
Plastic and reconstructive surgery, 134(4), 699-712. Lippincott Williams and Wilkins

Background: Adipose tissue-derived stromal cells augment wound healing and skin regeneration. It is unknown whether and how they can also influence dermal scarring. The authors hypothesized that adipose tissue-derived stromal cells inhibit adverse di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006cd0984690600a758be4f4cf31cd01
https://doi.org/10.1097/prs.0000000000000504

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Extracellular matrix components of adipose derived stromal cells promote alignment, organization, and maturation of cardiomyocytes in vitro

Autor: Martin C. Harmsen, Marja J. A. van Luyn, Ewa Przybyt

Publikováno v: Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 103(5), 1840-1848. Wiley-Blackwell

Adipose derived stromal cells (ADSC) are relevant therapeutic agents to treat myocardial infarction (MI) in clinical trials. Soluble factors secreted by ADSC, such as growth factors and cytokines, suppress inflammation and apoptosis while promoting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f907c1cdb4e09340fb3834a4435d3cd
https://doi.org/10.1002/jbm.a.35311

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Mesenchymal Stem Cells: Promising for Myocardial Regeneration?

Autor: Martin C. Harmsen, Ewa Przybyt

Publikováno v: Current stem cell research & therapy, 8(4), 270-277. BENTHAM SCIENCE PUBL LTD

The pandemic of cardiovascular disease is continuously expanding as the result of changing life styles and diets throughout the Old and New World. Immediate intervention therapy saves the lives of many patients after acute myocardial infarction (MI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be709be932c1f0dc4858663f759b3b4
https://doi.org/10.2174/1574888x11308040002

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Pericytes in the eye

Autor: Hans-Peter Hammes, Frederick Pfister, Martin C. Harmsen, Ewa Przybyt

Publikováno v: Pflügers Archiv - European Journal of Physiology. 465:789-796

Pericytes in the retina differ from pericytes in many other organs by their high density and their cooperative role in the neurovascular unit. Their diverse ontogeny and the fact that not one pericyte marker identifies the entire population suggest a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cde3773fa99adfbf7f4f8d48d92cc13
https://doi.org/10.1007/s00424-013-1272-6

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Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2

Autor: Ewa Przybyt, Guido Krenning, Marja G. L. Brinker, Martin C. Harmsen

Publikováno v: Journal of translational medicine, 11:39. BioMed Central Ltd.
Journal of Translational Medicine
Journal of Translational Medicine, Vol 11, Iss 1, p 39 (2013)

Background Experimental clinical stem cell therapy has been used for more than a decade to alleviate the adverse aftermath of acute myocardial infarction (aMI). The post-infarcted myocardial microenvironment is characterized by cardiomyocyte death, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edad01d64c23c52fac851001da4f941d
https://research.rug.nl/en/publications/07f02d85-d7de-40c4-aedc-d22905c3754b

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