Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ewa Malatynska"'
Levels of mRNA Coding for α-, β-, and γ-Synuclein in the Brains of Newborn, Juvenile, and Adult Rats
Autor:
Douglas E. Brenneman, Sergey E. Ilyin, Albert Pinhasov, Ewa Malatynska, Daniel Horowitz, Jeffrey Crooke
Publikováno v:
Journal of Molecular Neuroscience. 29:269-278
Synucleins are proteins known for their malfunction in a group of illnesses called synucleopathies, which includes Alzheimer's and Parkinson's disease. To learn more about the role of synucleins in the CNS, we have studied levels of message coding fo
Publikováno v:
Behavioural Pharmacology. 16:657-664
Submissive animals can be defined in a food competition test as spending significantly less time on the feeder than their dominant partners. Using observer-based scoring in the Reduction of Submissive Behavior Model, submissive behavior in rats and m
Autor:
Richard J. Knapp, Ewa Malatynska
Publikováno v:
Neuroscience & Biobehavioral Reviews. 29:715-737
This review examines the ways in which dominant-subordinate behavior in animals, as determined in laboratory studies, can be used to model depression and mania in humans. Affective disorders are mood illnesses with two opposite poles, melancholia (de
Autor:
Albert Pinhasov, Frank A. Amato, Douglas E. Brenneman, Anil H. Vaidya, Daniel I. Rosenthal, Sergey E. Ilyin, Jeffrey Crooke, Ewa Malatynska
Publikováno v:
Genes, Brain and Behavior. 4:60-64
Synucleins are small proteins regulating the filamentous network that in turn influences the release of dopamine and glutamate neurotransmitters involved in mood and motivation processes. We have studied the pattern of synuclein expression in animal
Autor:
Ewa Malatynska, Godfrey Tunnicliff
Publikováno v:
Neurochemical Research. 28:965-976
Clinical depression and other mood disorders are relatively common mental illnesses but therapy for a substantial number of patients is unsatisfactory. For many years clinicians and neuroscientists believed that the evidence pointed toward alteration
Autor:
Ewa Malatynska, Richard J. Knapp, Rachel Goldenberg, Paula Zamecki, Arif Haque, Glenda Crites, Lucy Shuck, Nancy L. Schindler
Publikováno v:
Pharmacology. 64:8-17
Randomly paired rats were food deprived overnight and placed in an apparatus compelling them to compete for a food reward. About half of these pairs developed a dominant-submissive relationship measured as a significant difference in time spent on th
Autor:
Dagmar Stropova, Victor J. Hruby, Jirina Slaninova, Henry I. Yamamura, F. Porreca, Ewa Malatynska, Peg Davis, Hubert Bartosz-Bechowski
Publikováno v:
The Journal of Peptide Research. 53:329-336
We report here on the binding affinity and bioassay results of cyclic enkephalin analogs comprising a cyclic moiety and C-terminal fragment of MERGL, where ME denotes methionine enkephalin. MERGL (YGGFMRGL) has been suggested to be cleaved enzymatica
Autor:
Nancy L. Schindler, Glenda Crites, Ewa Malatynska, Godfrey Tunnicliff, Rachel Goldenberg, Andrew Yochum
Publikováno v:
Neurochemical Research. 24:1271-1276
The clinically important antidepressant fluoxetine is established as a selective serotonin reuptake inhibitor. This study demonstrates that fluoxetine also interacts with the GABAA receptor complex. At concentrations above 10 μM fluoxetine inhibited
Autor:
Ryan Kopp, Ewa Malatynska, Andrew Yochum, Glenda Crites, Monique L. Giroux, Steven C. Dilsaver
Publikováno v:
Pharmacology. 57:117-123
We showed previously that antidepressants inhibit GABA-stimulated 36Cl– uptake in rat cerebral cortex. In this study Schild analysis was used to determine if antidepressants are competitive antagonists or allosteric modulators at GABAA receptors. G
Autor:
Michael E. Milewski, Bruce E. Maryanoff, H. Steve White, Mary Lou Lubin, Mark Herb, Michael F. A. Finley, Douglas E. Brenneman, Allen B. Reitz, Ewa Malatynska, Ning Qin, Karen S. Wilcox, Smith-Swintosky Virginia L, Yi Liu, Parker Michael H, Brian D. Klein, Mccomsey David F
Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, especially because of their potential for treating refractory patients. Such "neurostabilizers" have also been used to treat other neurological disorders, including m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8217beecc01fd20cf1673325073c638
https://europepmc.org/articles/PMC4004761/
https://europepmc.org/articles/PMC4004761/