Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ewa M. Urbanska"'
Autor:
Renata Kloc, Ewa M. Urbanska
Publikováno v:
Cells, Vol 13, Iss 17, p 1424 (2024)
Cytoprotective and neurotoxic kynurenines formed along the kynurenine pathway (KP) were identified as possible therapeutic targets in various neuropsychiatric conditions. Memantine, an adamantane derivative modulating dopamine-, noradrenaline-, serot
Externí odkaz:
https://doaj.org/article/333f2ff54a404896b9fa28da0ab5dfad
Publikováno v:
Nutrients, Vol 15, Iss 4, p 1030 (2023)
Anorexia nervosa (AN), affecting up to 4% of all females and 0.3% of all males globally, remains the neuropsychiatric disorder with the highest mortality rate. However, the response to the current therapeutic options is rarely satisfactory. Consideri
Externí odkaz:
https://doaj.org/article/bf3b724bb54848f9adbb4282c789b51d
Autor:
Kamila Kozieł, Ewa M. Urbanska
Publikováno v:
Cells, Vol 12, Iss 3, p 460 (2023)
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxi
Externí odkaz:
https://doaj.org/article/f6be6e1a45904faeae7a14583f166def
Autor:
Ewa Dudzińska, Kinga Szymona, Renata Kloc, Paulina Gil-Kulik, Tomasz Kocki, Małgorzata Świstowska, Jacek Bogucki, Janusz Kocki, Ewa M. Urbanska
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 12 (2019)
Background: Complex interaction of genetic defects with environmental factors seems to play a substantial role in the pathogenesis of inflammatory bowel disease (IBD). Accumulating data implicate a potential role of disturbed tryptophan metabolism in
Externí odkaz:
https://doaj.org/article/2f31bc1e93a04c8baf6f129e2f97918e
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9940 (2024)
Kidney transplantation significantly improves the survival of patients with end-stage kidney disease (ESKD) compared to other forms of kidney replacement therapy. However, kidney transplant recipients’ outcomes are not fully satisfactory due to inc
Externí odkaz:
https://doaj.org/article/36f52b19160d40fbbeadde1e9c10be34
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2915 (2024)
In the era of a steadily increasing lifespan, neurodegenerative diseases among the elderly present a significant therapeutic and socio-economic challenge. A properly balanced diet and microbiome diversity have been receiving increasing attention as t
Externí odkaz:
https://doaj.org/article/98df0a0d5cda49ae8823baee02c1205e
Publikováno v:
Life, Vol 14, Iss 1, p 127 (2024)
Kynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarb
Externí odkaz:
https://doaj.org/article/bfdd40de7daf46c4833978f613ed6ade
Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 ‐/‐ mice
Autor:
Erling Norrby, Ewa M. Urbanska, Hans-Gustaf Ljunggren, Krister Kristensson, Benedict J. Chambers
Publikováno v:
Journal of Medical Virology. 52:362-369
The spread of measles virus into the brain was studied exploiting the olfactory pathway, which represents an important route of neuroinvasion by viruses. The virus was injected into the main olfactory bulb of wild-type mice and mice with disrupted TA
Publikováno v:
Acta neurobiologiae experimentalis. 63(2)
Kynurenic acid (KYNA), the only known endogenous glutamate antagonist, is produced in the brain by kynurenine aminotransferases (KATs) I and II. Mitochondrial toxins, 1-methyl-4-phenylpyridinium (MPP +) and 3-nitropropionic acid (3-NPA), were previou
Autor:
Iwona Chmiel-Perzyńska, Adam Perzyński, Bartosz Olajossy, Paulina Gil-Kulik, Janusz Kocki, Ewa M. Urbańska
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood. Kynurenic acid (KYNA), endogenous kynurenine metabolite, displays pleiotropic effects, i
Externí odkaz:
https://doaj.org/article/4d88eeb0b9a74e9e9a161ba90f4d1d92