Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ewa M. Musiol-Kroll"'
Autor:
Lena Mitousis, Hannes Maier, Luka Martinovic, Andreas Kulik, Sigrid Stockert, Wolfgang Wohlleben, Alfred Stiefel, Ewa M. Musiol-Kroll
Publikováno v:
Molecules, Vol 26, Iss 14, p 4343 (2021)
Tobramycin is a broad-spectrum aminoglycoside antibiotic agent. The compound is obtained from the base-catalyzed hydrolysis of carbamoyltobramycin (CTB), which is naturally produced by the actinomycete Streptoalloteichus tenebrarius. However, the str
Externí odkaz:
https://doaj.org/article/598cc7ec213d4d35952f716b5198dc2c
Publikováno v:
Antibiotics, Vol 9, Iss 8, p 494 (2020)
The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which several species were identified and demonstrated to be a great sourc
Externí odkaz:
https://doaj.org/article/356dc2e94f19413b979a3c577edaa3bc
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 157 (2019)
Actinomycetes are remarkable producers of compounds essential for human and veterinary medicine as well as for agriculture. The genomes of those microorganisms possess several sets of genes (biosynthetic gene cluster (BGC)) encoding pathways for the
Externí odkaz:
https://doaj.org/article/6c7ddf8b51a0486caefaf616daccb92f
Publikováno v:
Natural Product Reports. 36:1351-1369
Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c6374cfb0ca1913c208ae0783ea46c
https://doi.org/10.1039/c9np00029a
https://doi.org/10.1039/c9np00029a
Autor:
John B. McArthur, Stephanie Grond, Tilmann Weber, Thomas Schafhauser, Gavin J. Williams, Thomas Härtner, Wolfgang Wohlleben, Florian Zubeil, Sang Yup Lee, Ewa M. Musiol-Kroll, Irina Koryakina, Andreas Kulik
Publikováno v:
ACS Synthetic Biology. 6:421-427
During polyketide biosynthesis, acyltransferases (ATs) are the essential gatekeepers which provide the assembly lines with precursors and thus contribute greatly to structural diversity. Previously, we demonstrated that the discrete AT KirCII from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71f06189de8a4861106be8f26e0777c
https://doi.org/10.1021/acssynbio.6b00341
https://doi.org/10.1021/acssynbio.6b00341
Publikováno v:
Antibiotics
Antibiotics, Vol 9, Iss 494, p 494 (2020)
Antibiotics, Vol 9, Iss 494, p 494 (2020)
The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which several species were identified and demonstrated to be a great sourc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5ad8769af2594e087c4131d4feebe2
https://doi.org/10.3390/antibiotics9080494
https://doi.org/10.3390/antibiotics9080494
Autor:
Wolfgang Wohlleben, Helene Lunde Robertsen, Stephanie Grond, Torben Hofeditz, Kristina J. Laiple, Tilmann Weber, Ewa M. Musiol-Kroll, Sang Yup Lee, Ling Ding
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Robertsen, H L, Musiol-Kroll, E M, Ding, L, Laiple, K J, Hofeditz, T, Wohlleben, W, Lee, S Y, Grond, S & Weber, T 2018, ' Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions ', Scientific Reports, vol. 8, 3230 . https://doi.org/10.1038/s41598-018-21507-6
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Robertsen, H L, Musiol-Kroll, E M, Ding, L, Laiple, K J, Hofeditz, T, Wohlleben, W, Lee, S Y, Grond, S & Weber, T 2018, ' Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions ', Scientific Reports, vol. 8, 3230 . https://doi.org/10.1038/s41598-018-21507-6
Kirromycin is the main product of the soil-dwelling Streptomyces collinus Tü 365. The elucidation of the biosynthetic pathway revealed that the antibiotic is synthesised via a unique combination of trans-/cis-AT type I polyketide synthases and non-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a3aaa617f5547a6e9bccd38ae41152
http://europepmc.org/articles/PMC5818483
http://europepmc.org/articles/PMC5818483
Autor:
Yaojun Tong, Pep Charusanti, Hyun Uk Kim, Ewa M. Musiol-Kroll, Xinglin Jiang, Tilmann Weber, Sang Yup Lee
Publikováno v:
Trends in biotechnology. 33(1)
Actinomycetes are excellent sources for novel bioactive compounds, which serve as potential drug candidates for antibiotics development. While industrial efforts to find and develop novel antimicrobials have been severely reduced during the past two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed63d6fb0beba5d4a7cf47eb5f94a8a5
https://pubmed.ncbi.nlm.nih.gov/25497361
https://pubmed.ncbi.nlm.nih.gov/25497361