Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ewa M Michalak"'
Autor:
Ewa M Michalak, Michael J G Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2004986 (2018)
Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive and active histone modifications, into tightly packaged heterochromatin versus more accessible euchromatin. Polycomb repre
Externí odkaz:
https://doaj.org/article/2db4d265c7794554b6a813e67f3a5cdf
Autor:
Ivo J Huijbers, Rahmen Bin Ali, Colin Pritchard, Miranda Cozijnsen, Min‐Chul Kwon, Natalie Proost, Ji‐Ying Song, Hilda de Vries, Jitendra Badhai, Kate Sutherland, Paul Krimpenfort, Ewa M Michalak, Jos Jonkers, Anton Berns
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 2, Pp 212-225 (2014)
Abstract Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these
Externí odkaz:
https://doaj.org/article/eb23552beda443f999513453e1461b4a
Autor:
Liz J. Valente, Daniel H.D. Gray, Ewa M. Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L. Scott, Ana Janic, Andreas Strasser
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1339-1345 (2013)
Activation of apoptosis through transcriptional induction of Puma and Noxa has long been considered to constitute the critical (if not sole) process by which p53 suppresses tumor development, although G1/S boundary cell-cycle arrest via induction of
Externí odkaz:
https://doaj.org/article/c8b0052170ea409c904148d77c52dc70
Publikováno v:
Nature reviews. Molecular cell biology. 20(10)
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins and RNA. The methylation of chromatin components is highly conserved as it helps coordinate the regulation of gene expression, DNA repair and DNA replication. Dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f11e12de560266e4d352539aa64cc1a
https://pubmed.ncbi.nlm.nih.gov/31270442
https://pubmed.ncbi.nlm.nih.gov/31270442
Autor:
Ewa M. Michalak, Jane E. Visvader
Publikováno v:
Molecular Oncology. 10:1497-1515
Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non‐histone targets. These important post‐translational modifications are exquisitely regulated and affect chromatin compaction and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7526a9c8479f60a1e039dd04f51d379f
https://doi.org/10.1016/j.molonc.2016.09.003
https://doi.org/10.1016/j.molonc.2016.09.003
Autor:
Michael J. G. Milevskiy, Bhupinder Pal, Caleb A. Dawson, Paul R. Jamieson, Ewa M. Michalak, Geoffrey J. Lindeman, Stuart H. Orkin, Johanna F. Dekkers, Yifang Hu, Gordon K. Smyth, Rachel Joyce, Warren S. Alexander, Jane E. Visvader
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2004986 (2018)
PLoS Biology
PLoS Biology
Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive and active histone modifications, into tightly packaged heterochromatin versus more accessible euchromatin. Polycomb repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c214c52ce4458fb5c1b0188d97fa7b94
http://europepmc.org/articles/PMC6095611?pdf=render
http://europepmc.org/articles/PMC6095611?pdf=render
Autor:
Ewa M. Michalak, Anton Berns, Jos Jonkers, Kate D. Sutherland, Hilda de Vries, Jitendra Badhai, Rahmen Bin Ali, Miranda Cozijnsen, Natalie Proost, Colin Pritchard, Ivo J. Huijbers, Minchul Kwon, Ji-Ying Song, Paul Krimpenfort
Publikováno v:
EMBO Molecular Medicine
Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1435b4dece84298b99932f312533c670
https://doi.org/10.1002/emmm.201303297
https://doi.org/10.1002/emmm.201303297
Autor:
Kate D. Sutherland, Carleen Cullinane, Hannah V. Siddle, Ewa M. Michalak, Rab K. Prinjha, Ariena Kersbergen, Sarah-Jane Dawson, Omer Gilan, Lavinia Tan, Sebastian Hollizeck, Paul J. Lehner, Christina E. Sparbier, Benjamin Solomon, Elizabeth Azidis-Yates, Susan Jackson, Kah Lok Chan, Marian L. Burr, Yih-Chih Chan, Richard W. Tothill, Mark A. Dawson, Shahneen Sandhu, Dane Vassiliadis, Stephen Q. Wong, Charles C. Bell, Enid Y.N. Lam, Glen R. Guerra, Paul A. Beavis, Michael T. McCabe
Publikováno v:
Cancer Cell
Summary Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bef9c9945a6af8eb8fbbcedb8ba152
http://europepmc.org/articles/PMC6876280
http://europepmc.org/articles/PMC6876280
Autor:
Ewa M. Michalak, Lindsay C. Spender, Louise J. Clark, Gareth J. Inman, Mark S. Cragg, Jian Yu, Matthew J. Carter, Lina Happo, Darren I. O'Brien
Publikováno v:
The Journal of Biological Chemistry
Background: TGF-β induces apoptosis in Burkitt's lymphoma cells. Results: PUMA is a direct target gene of TGF-β signaling and is required for rapid apoptosis. Conclusion: TGF-β-mediated direct induction of PUMA contributes to apoptosis in human an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eb6346de27bc80230cd84f3351e49a
https://doi.org/10.1074/jbc.m112.410274
https://doi.org/10.1074/jbc.m112.410274
Autor:
Jock K. Findlay, Ewa M. Michalak, Michele Cook, Alea A. Mills, Karla J. Hutt, Andreas Strasser, Cassandra J. Vandenberg, Seng H. Liew, Clare L. Scott, Philippe Bouillet, Jeffrey B. Kerr
Publikováno v:
Molecular Cell. 48:343-352
Trp63, a transcription factor related to the tumor suppressor p53, is activated by diverse stimuli and can initiate a range of cellular responses. TAp63 is the predominant Trp53 family member in primordial follicle oocyte nuclei and is essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449a9d88643e02f275658dc397cdd773
https://doi.org/10.1016/j.molcel.2012.08.017
https://doi.org/10.1016/j.molcel.2012.08.017