Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ewa Hellström-Lindahl"'
Autor:
Olof Eriksson, Olle Korsgren, Lars Johansson, Paul Czernichow, Ewa Hellström-Lindahl, Angelika Danielsson, Fredrik Pontén
Publikováno v:
Acta Diabetologica. 53:413-421
To address questions regarding onset and progression of types 1 and 2 diabetes (T1D/T2D), surrogate imaging biomarkers for beta cell function and mass are needed. Here, we assess the potential of GPR44 as a surrogate marker for beta cells, in a direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4e080504dbf8e88daaaa3f3c358701
https://doi.org/10.1007/s00592-015-0811-3
https://doi.org/10.1007/s00592-015-0811-3
Autor:
Ola Åberg, Olof Eriksson, Gavin O'Mahony, Ewa Hellström-Lindahl, Peter Johnström, Stanko Skrtic, Cecilia Ericsson
Publikováno v:
Acta Diabetologica
Aims Molecular imaging of the free fatty acid receptor 1 (FFAR1) would be a valuable tool for drug development by enabling in vivo target engagement studies in human. It has also been suggested as a putative target for beta cell imaging, but the inhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370d299c91c4c4d54a30aba55a76dbf7
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329002
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329002
Publikováno v:
Amyloid. 21:21-27
Systemic amyloidosis is caused by extracellular deposition of insoluble fibrillar proteins arranged in β-pleated sheets. [11C]PIB has been used in PET studies to assess Aβ deposition in brain of patients with Alzheimer’s disease (AD). The possibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eda5d2285820926459cdfd2ed80dd5e
https://doi.org/10.3109/13506129.2013.860895
https://doi.org/10.3109/13506129.2013.860895
Publikováno v:
Neurochemistry International. 55:243-252
Mutations in presenilin (PS) and amyloid precursor protein (APP) genes are a predominant cause for early-onset familial Alzheimer disease (AD). Although these mutations are rare, they have in the past decades advanced our understanding of the underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631fd0748c73bb21591d8888858c2903
https://doi.org/10.1016/j.neuint.2009.03.007
https://doi.org/10.1016/j.neuint.2009.03.007
Autor:
Jennifer A. Court, Elaine K. Perry, Agneta Nordberg, Amelia Marutle, Alan J. Thomas, I. Bednar, M. Lee, Ewa Hellström-Lindahl, Marie Svedberg, Jessica Keverne
Publikováno v:
European Journal of Neuroscience. 19:2703-2710
Ten days treatment with nicotine reduced insoluble amyloid A beta 1-40 and Alpha beta 1-42 peptides by 80% in the cortex of 9-month-old APPsw mice, which is more than that observed in 14.5-month-old mice following nicotine treatment for 5.5 months. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c36545d1a52023b370fa5a31811788
https://doi.org/10.1111/j.0953-816x.2004.03377.x
https://doi.org/10.1111/j.0953-816x.2004.03377.x
Autor:
Hermona Soreq, Zhi-Zhong Guan, Ewa Hellström-Lindahl, Cesar Flores-Flores, Taher Darreh-Shori, Agneta Nordberg
Publikováno v:
Journal of Neurochemistry. 88:1102-1113
Protein levels of different acetylcholinesterase (AChE) splice variants were explored by a combination of immunoblot techniques, using two different antibodies, directed against the C-terminus of the AChE-R splice variant or the core domain common to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::141051d377b6c6c174a77136c348b41e
https://doi.org/10.1046/j.1471-4159.2003.02230.x
https://doi.org/10.1046/j.1471-4159.2003.02230.x
Publikováno v:
Neuroscience Letters. 338:159-163
We evaluated cerebral glucose metabolism (CMRglc) and cerebrospinal fluid (CSF) levels of tau and beta-amyloid(1-42) (Abeta42), in relation to apolipoprotein E (ApoE) genotype, in patients with mild Alzheimer disease (AD) treated with rivastigmine (n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b14a5d23ba85ecb6b36465e57ed75e
https://doi.org/10.1016/s0304-3940(02)01384-8
https://doi.org/10.1016/s0304-3940(02)01384-8
Autor:
Malahat Mousavi, K.-R Shan, Ewa Hellström-Lindahl, Zhi-Zhong Guan, Rivka Ravid, Agneta Nordberg
Publikováno v:
Neuroscience. 122:515-520
The neuronal nicotinic receptors (nAChRs) are involved in several processes in brain including nicotine dependence and cognitive disorders. While the number of nAChRs in the brain of tobacco smokers is up-regulated, the receptors are reduced in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec9994d216744bb8e5b14b675f97ee5
https://doi.org/10.1016/s0306-4522(03)00460-3
https://doi.org/10.1016/s0306-4522(03)00460-3
Autor:
Xiao Zhang, Jukka Puoliväli, Heikki Tanila, Jun Wang, Agneta Nordberg, Christina Unger, Ewa Hellström-Lindahl, Amelia Marutle
Publikováno v:
Neuroscience Letters. 328:269-272
The binding sites of nicotinic acetylcholine receptor (nAChR) subtypes were measured in the parietal cortex and hippocampus of transgenic mice carrying mutant human APPswe and presenilin 1 (PS1) genes (APPswe/PS1 mice) between the ages of 3 weeks and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f227afd8de14fa94f840cace30cc79e0
https://doi.org/10.1016/s0304-3940(02)00546-3
https://doi.org/10.1016/s0304-3940(02)00546-3
Autor:
M. Lee, Jennifer A. Court, Elaine K. Perry, Mary Johnson, Ros Hall, Agneta Nordberg, I. Bednar, Malahat Mousavi, Ewa Hellström-Lindahl
Publikováno v:
Journal of Neurochemistry. 81:655-658
Alzheimer's disease neuropathology is characterised by beta-amyloid plaques and neurofibrillary tangles. Inhibition of beta-amyloid accumulation may be essential for effective therapy in Alzheimer's disease. In this study we have treated transgenic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1faec805afb29ccfbbf515e611d7f4
https://doi.org/10.1046/j.1471-4159.2002.00874.x
https://doi.org/10.1046/j.1471-4159.2002.00874.x