Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ewa Gurgul-Convey"'
Autor:
Yadi Tang, Mariola Majewska, Britta Leß, Ilir Mehmeti, Philipp Wollnitzke, Nina Semleit, Bodo Levkau, Julie D. Saba, Gerhild van Echten-Deckert, Ewa Gurgul-Convey
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 8, Pp 100587- (2024)
Lipotoxicity has been considered the main cause of pancreatic beta-cell failure during type 2 diabetes development. Lipid droplets (LD) are believed to regulate the beta-cell sensitivity to free fatty acids (FFA), but the underlying molecular mechani
Externí odkaz:
https://doaj.org/article/f3e16ef9cddd4886b684f4887a91e450
Publikováno v:
Archives of Medical Science, Vol 19, Iss 4, Pp 895-911 (2020)
The immune system is frequently described in the context of its protective function against infections and its role in the development of autoimmunity. For more than a decade, the interactions between the immune system and metabolic processes have be
Externí odkaz:
https://doaj.org/article/b9148d9d5dfd4abb96822e31c9dba330
Autor:
Ewa Gurgul-Convey
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1638 (2022)
Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid with multiple functions conveyed by the activation of cell surface receptors and/or intracellular mediators. A growing body of evidence indicates its important role in pancreatic insulin-secre
Externí odkaz:
https://doaj.org/article/c91ebf677e0e446390c7b96e95b657d7
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10893 (2021)
Elevated levels of free fatty acids (FFAs) have been related to pancreatic beta-cell failure in type 2 diabetes (T2DM), though the underlying mechanisms are not yet fully understood. FFAs have been shown to dysregulate formation of bioactive sphingol
Externí odkaz:
https://doaj.org/article/3ba92aebc2634abf998e89d1ebf6812a
Autor:
Ewa Gurgul-Convey
Publikováno v:
Cells, Vol 9, Iss 8, p 1835 (2020)
Type 1 diabetes (T1DM) is a chronic autoimmune disease, with a strong genetic background, leading to a gradual loss of pancreatic beta-cells, which secrete insulin and control glucose homeostasis. Patients with T1DM require life-long substitution wit
Externí odkaz:
https://doaj.org/article/9d7365ca8c034a95a292d2a2e09f6720
Autor:
Rabea Dettmer, Isabell Niwolik, Karsten Cirksena, Toshiaki Yoshimoto, Yadi Tang, Ilir Mehmeti, Ewa Gurgul-Convey, Ortwin Naujok
Publikováno v:
Diabetologia. 65(5)
Aims/hypothesis The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a922918eb6b174182a8b733e278b60
https://pubmed.ncbi.nlm.nih.gov/35122482
https://pubmed.ncbi.nlm.nih.gov/35122482
Autor:
Tenna Holgersen Bryde, Anne Jörns, Alessia Dunst, Yadi Tang, Ewa Gurgul-Convey, Lorella Marselli, Karolina Tyka, Miriam Cnop, Michal Marzec, Anna Walentinsson, Björn Tyrberg, Ilir Mehmeti
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease, 1867 (10
SCOPUS: ar.j
info:eu-repo/semantics/published
info:eu-repo/semantics/published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672fadb4ee6cb1df2bfb2259519255e9
https://pubmed.ncbi.nlm.nih.gov/34144091
https://pubmed.ncbi.nlm.nih.gov/34144091
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10893, p 10893 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10893, p 10893 (2021)
Elevated levels of free fatty acids (FFAs) have been related to pancreatic beta-cell failure in type 2 diabetes (T2DM), though the underlying mechanisms are not yet fully understood. FFAs have been shown to dysregulate formation of bioactive sphingol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4c472e19c0509c4185faf797059f31
https://doi.org/10.3390/ijms221910893
https://doi.org/10.3390/ijms221910893
Autor:
Jean Valéry Turatsinze, Sigurd Lenzen, Ewa Gurgul-Convey, Karolina Tyka, Anne Jörns, Decio L. Eizirik
Publikováno v:
Cell death and disease, 10 (1
Cell Death and Disease, Vol 10, Iss 1, Pp 1-17 (2019)
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 1, Pp 1-17 (2019)
Cell Death & Disease
The autoimmune-mediated beta-cell death in type 1 diabetes (T1DM) is associated with local inflammation (insulitis). We examined the role of MCPIP1 (monocyte chemotactic protein–induced protein 1), a novel cytokine-induced antiinflammatory protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc568989d96a0ebc00c19d4a6a6166c4
https://doi.org/10.1038/s41419-018-1268-4
https://doi.org/10.1038/s41419-018-1268-4
Publikováno v:
Diabetologia. 59:2125-2133
The aim of this study was to perform a detailed analysis of cytokine toxicity in the new human EndoC-βH1 beta cell line. The expression profile of the antioxidative enzymes in the new human EndoC-βH1 beta cells was characterised and compared with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318bf36c6b685d0075b843a242e3b086
https://doi.org/10.1007/s00125-016-4060-y
https://doi.org/10.1007/s00125-016-4060-y