Expression of Difficult-to-Express Proteins, Human IL-12 and IFN-γ

Autor: Yukaze Mizoura, Shun Matsutani, Shinya Kawate, Kei Itoh, Seiya Uemura, Sayumi Yamada, A B Miura, Ewa Grave, Hiroshi Konno, Hideki Wakui, Hideaki Itoh, Yoshihito Hosaka

Publikováno v: American Journal of Molecular Biology. 11:29-37

It is known to be that lactic acid bacteria induce the IL-12. IL-12 activates NK cells and promotes the production of IFN-γ. IFN-γ activates macrophages, resulting in enhanced phagocytosis and bactericidal activity. We have been investigating ferme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60846023cfe1621405c18d865ff58622
https://doi.org/10.4236/ajmb.2021.112003

Fermented food Tempeh induces interleukin 12 and enhances macrophage phagocytosis

Autor: Sayumi Yamada, Hideaki Itoh, Shinya Kawate, Shun Matsutani, Yoshihito Hosaka, A B Miura, Ewa Grave, Yukaze Mizoura, Hiroshi Konno, Koji Nagata, Hideki Wakui, Kei Itoh

Publikováno v: Journal of Food Biochemistry. 45

It is known that lactic acid bacteria induce the IL-12. The IL-12 activates NK cells and promotes the production of IFN-I³. The IFN-I³ activates macrophages resulting in enhanced phagocytosis and bactericidal activity. We have been investigating fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a38cc8b9690c1f6db743f75fee0825e
https://doi.org/10.1111/jfbc.13958

High dose of antibiotic colistin induces oligomerization of molecular chaperone HSP90

Autor: Kyosuke Takahashi, Tomoya Okamoto, Ikuru Kudo, Asami Haga, Taku Sugawara, Atsushi Komatsuda, Shuntaro Togashi, Ikumi Toyota, Asuka Miyamoto, Hideaki Itoh, Hiroaki Shimizu, Shiori Hatakeyama, Ewa Grave, Arisa Tamura, Erina Sasaki Kudoh

Publikováno v: The Journal of Biochemistry. 162:27-36

Colistin is an antimicrobial cationic peptide that belongs to the polymyxin family. Colistin was clinically used for the treatment of gram-negative infections but fell out of favour because of its significant side effects including neurotoxicity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ac4b06e9e0fd5c5bde2e04c59f0c7
https://doi.org/10.1093/jb/mvw104

Physicochemical Properties of the Mammalian Molecular Chaperone HSP60

Autor: Toshihiko Oka, Akira Kitamura, Michiro Otaka, Tomoya Okamoto, Masasuke Yoshida, Ewa Grave, Masataka Kinjo, Masako Tanabe, Hiroshi Kubota, Hiroki Takahashi, Ryuichi Ishida, Fumihiro Motojima, Hideaki Itoh

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 2; Pages: 489
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 489 (2018)

The E. coli GroEL/GroES chaperonin complex acts as a folding cage by producing a bullet-like asymmetric complex, and GroEL exists as double rings regardless of the presence of adenosine triphosphate (ATP). Its mammalian chaperonin homolog, heat shock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0779606761a5344d414642da1df3481

The regulation mechanisms of AhR by molecular chaperone complex

Autor: Yuka Kakizaki, Hideaki Itoh, Yuhtaroh Nagata, Asami Haga, Noriko Tsuji, Miki Hosaka, Ewa Grave, Ikuru Kudo, Tomoya Okamoto, Kana Fukuda, Hirotaka Okada

Publikováno v: Journal of biochemistry. 163(3)

The AhR, so called the dioxin receptor, is a member of the nuclear receptor superfamily. The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and XAP2 in the cytoplasm. Following ligand binding l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0e5e419392e7221a1e22a961f1144d
https://pubmed.ncbi.nlm.nih.gov/29092071