A Metabolomic Perspective on Coeliac Disease

Autor: Antonio Calabrò, Ewa Gralka, Claudio Luchinat, Edoardo Saccenti, Leonardo Tenori

Publikováno v: Autoimmune Diseases, Vol 2014 (2014)

Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or bio

Externí odkaz: https://doaj.org/article/dadfa71ea1174e838123414d9a132cc2

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Autor: Justyna Jozefczuk, Samrina Rehman, Christian R. A. Regenbrecht, Christoph Wierling, Wasco Wruck, Hans V. Westerhoff, Paola Turano, Ewa Gralka, Andriani Daskalaki, Kurt Zatloukal, Katharina Drews, Vikash Pandey, Hans Lehrach, Daniela Berg, Karl Kashofer, James Adjaye, Ulrike Korf

Publikováno v: Scientific Data
Wruck, W, Kashofer, K, Rehman, S, Daskalaki, A, Berg, D, Gralka, E, Jozefczuk, J, Drews, K, Pandey, V, Regenbrecht, C, Wierling, C, Turano, P, Korf, U, Zatloukal, K, Lehrach, H, Westerhoff, H V & Adjaye, J 2015, ' Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. ', Scientific Data, vol. 2, 150068 . https://doi.org/10.1038/sdata.2015.68
Scientific Data, 2:150068. Nature Publishing Group

Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cccd66a930ba17d8d02af9748e2157
https://hdl.handle.net/11858/00-001M-0000-002D-434E-311858/00-001M-0000-002D-434C-7

Serum metabolomic profiles evaluated after surgery may identify patients with oestrogen receptor negative early breast cancer at increased risk of disease recurrence. Results from a retrospective study

Autor: Claudio Luchinat, Catherine Oakman, Cliff Hudis, Angelo Di Leo, Patrick G. Morris, Silvia Cappadona, Ewa Gralka, Leonardo Tenori, Larry Norton, Monica Fornier, Natalie Turner

Purpose : Metabolomics is a global study of metabolites in biological samples. In this study we explored whether serum metabolomic spectra could distinguish between early and metastatic breast cancer patients and predict disease relapse. Methods : Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba12d5d16a9251dd6d5493d1a899eb8
http://hdl.handle.net/2158/949162

Thermodynamic and spectroscopic investigation on the role of Met residues in Cu II binding to the non-octarepeat site of the human prion protein

Autor: Erika Marzola, Ewa Gralka, Leonardo Toso, Daniela Valensin, Henryk Kozlowski, Maurizio Remelli, Remo Guerrini

Among the common features shared by neurodegenerative diseases there is the central role played by specific proteins or peptides which accumulate in neurons as insoluble plaques or tangles, containing abnormal amounts of redox-active metal ions, like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df065baddcc68886cb7e803417dbb9e
http://hdl.handle.net/11365/39858

Copper(II) coordination outside tandem repeat region of an unstructured domain of chicken prion protein

Autor: Gianni Valensin, Wojciech Kamasz, Wioletta Barańska-Rybak, Maurizio Remelli, Dimitri Bacco, Daniela Valensin, Karolina Gajda, Ewa Gralka, Łukasz Szyrwiel, Henryk Kozlowski

Combined potentiometric, calorimetric and spectroscopic methods were used to investigate the Cu(2+) binding ability and coordination behaviour of some peptide fragments related to the neurotoxic region of chicken Prion Protein. The systems studied we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f06db7dffad75bf07a0d7f47cbdf23
http://hdl.handle.net/11392/534309