Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Ewa Galaj"'
Autor:
Ewa Galaj, Briana Hempel, Allamar Moore, Benjamin Klein, Guo-Hua Bi, Eliot L. Gardner, Herbert H. Seltzman, Zheng-Xiong Xi
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Cannabinoid CB1 receptors (CB1Rs) have been major targets in medication development for the treatment of substance use disorders. However, clinical trials with rimonabant, a CB1R antagonist/inverse agonist, failed due to severe side effects.
Externí odkaz:
https://doaj.org/article/77cb5c67ba57479a947e4b25fda32476
Autor:
Shihao Huang, Ewa Galaj, Jinfeng Wang, Yi Guo, Shuang Wang, Mengxu Shi, Xueyong Yin, Keyao Liu, Yixiao Luo, Li Meng, Haishui Shi
Publikováno v:
Brain and Behavior, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Introduction Several studies have linked inflammation and oxidative stress with the pathogenesis of depression. Artesunate is a commonly used medication to treat malaria and has been shown to produce antioxidant, anti‐inflammatory, and imm
Externí odkaz:
https://doaj.org/article/27fc9feca8154ab2a557b24083f09ad0
Autor:
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Carbon monoxide (CO), a byproduct of heme catalyzed by heme oxygenase (HO), has been reported to exert antioxidant and anti-inflammatory actions, and to produce significant neuroprotective effects. The potential effects of CO and even HO on depressiv
Externí odkaz:
https://doaj.org/article/45210d806236489883266b9dfdf45b68
Autor:
Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with a CB2 receptor agonist profile, has therapeutic effects on methamp
Externí odkaz:
https://doaj.org/article/77d2f6495d7b4322abc73da05b1aacb6
Autor:
Liangpei Chen, Shihao Huang, Chang Yang, Feilong Wu, Qiuyao Zheng, He Yan, Jie Yan, Yixiao Luo, Ewa Galaj
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Persistent traces of drug reward memories contribute to intense craving and often trigger relapse. A number of pharmacological interventions on drug-associated memories have shown significant benefits in relapse prevention at a preclinical level but
Externí odkaz:
https://doaj.org/article/f5a5fcadd332499fbf3a7278461d9f89
Autor:
Xi Shen, Rongji Hui, Yixiao Luo, Hailei Yu, Suiyuan Feng, Bing Xie, Haitao Bi, Ewa Galaj, Bin Cong, Chunling Ma, Di Wen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse. A number of interventions on drug-associated memories ha
Externí odkaz:
https://doaj.org/article/11fad10cdc9f41ec9aba8765d1bf47b5
Autor:
Ewa Galaj, Zheng-Xiong Xi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 134 (2020)
Substance use disorder (SUD) is a serious public health problem worldwide for which available treatments show limited effectiveness. Since the legalization of cannabis and the approval of cannabidiol (CBD) by the US Food and Drug Administration, ther
Externí odkaz:
https://doaj.org/article/f2b514fd167e48899d6091f85efc299e
Autor:
Ewa Galaj, Guo-Hua Bi, Benjamin Klein, Briana Hempel, Anver Basha Shaik, Emma S. Gogarnoiu, Jacob Friedman, Jenny Lam, Rana Rais, John F. Reed, Shelley H. Bloom, Tracy L. Swanson, Jennifer L. Schmachtenberg, Amy J. Eshleman, Aaron Janowsky, Zheng-Xiong Xi, Amy Hauck Newman
Publikováno v:
Neuropsychopharmacology. 47:2309-2318
Autor:
Qianchao, Shen, Bing, Xie, Ewa, Galaj, Hailei, Yu, Xiaojie, Li, Yun, Lu, Minglong, Zhang, Di, Wen, Chunling, Ma
Publikováno v:
Brain Research Bulletin. 185:64-73
Reconsolidation of drug memories is the process of restoring unstable memories after unconditioned (UCS; e.g., drugs) or conditioned stimulus (CS; e.g., drug-paired contexts), and provides promise for prevention of drug relapse. Circular RNAs (circRN
Autor:
Zhi-Bing You, Eliot L. Gardner, Ewa Galaj, Allamar R. Moore, Tristram Buck, Chloe J. Jordan, Bree A. Humburg, Guo-Hua Bi, Zheng-Xiong Xi, Lorenzo Leggio
Publikováno v:
Mol Psychiatry
Ghrelin, an orexigenic hormone, has emerged as a critical biological substrate implicated in drug reward. However, the response of the ghrelin system to opioid-motivated behaviors and the role of ghrelin in oxycodone self-administration remain to be