Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ewa Damrath"'
Autor:
Nesli Ece Sen, Jessica Drost, Suzana Gispert, Sylvia Torres-Odio, Ewa Damrath, Michael Klinkenberg, Hamid Hamzeiy, Gülden Akdal, Halil Güllüoğlu, A. Nazlı Başak, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 115-126 (2016)
Ataxin-2 (ATXN2) polyglutamine domain expansions of large size result in an autosomal dominantly inherited multi-system-atrophy of the nervous system named spinocerebellar ataxia type 2 (SCA2), while expansions of intermediate size act as polygenic r
Externí odkaz:
https://doaj.org/article/cb8f42da3ff6407ba98ba51f0467cbed
Autor:
Melanie Vanessa Halbach, Tanja Stehning, Ewa Damrath, Marina Jendrach, Nesli Ece Şen, A Nazlı Başak, Georg Auburger
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121089 (2015)
The involvement of the ubiquitin-proteasome system (UPS) in the course of various age-associated neurodegenerative diseases is well established. The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson's disease (PD) va
Externí odkaz:
https://doaj.org/article/a8b7e44dac9645efb768cd213579fb17
Autor:
Ewa Damrath, Melanie V Heck, Suzana Gispert, Mekhman Azizov, Joachim Nowock, Carola Seifried, Udo Rüb, Michael Walter, Georg Auburger
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002920 (2012)
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)(31). This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, re
Externí odkaz:
https://doaj.org/article/815fe744f4334f3f9d6909297a8b481f
Autor:
Nesli-Ece Sen, Sylvia Torres-Odio, Halil Güllüoğlu, Gülden Akdal, Ewa Damrath, Suzana Gispert, Jessica Drost, A. Nazli Basak, Hamid Hamzeiy, Michael Klinkenberg, Georg Auburger
Publikováno v:
Neurobiology of disease 96, 115-126 (2016). doi:10.1016/j.nbd.2016.09.002
Neurobiology of Disease, Vol 96, Iss, Pp 115-126 (2016)
Neurobiology of Disease, Vol 96, Iss, Pp 115-126 (2016)
Ataxin-2 (ATXN2) polyglutamine domain expansions of large size result in an autosomal dominantly inherited multi-system-atrophy of the nervous system named spinocerebellar ataxia type 2 (SCA2), while expansions of intermediate size act as polygenic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d977f7a0e8065fda7c7f94e6fb1cd
https://avesis.deu.edu.tr/publication/details/e57de45d-a606-45d0-a522-1d0cb2b84c01/oai
https://avesis.deu.edu.tr/publication/details/e57de45d-a606-45d0-a522-1d0cb2b84c01/oai
Autor:
Georg Auburger, Rolf Heumann, Florian Eich, Jessica Drost, Oliver Leske, Ewout R. Brunt, Joachim Nowock, Ewa Damrath, Isabel Lastres-Becker, David Nonis
Publikováno v:
Journal of Molecular Neuroscience
Journal of molecular neuroscience, 51(1), 68-81
Journal of molecular neuroscience, 51(1), 68-81
Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain o
Autor:
Michael Walter, Monica Fittschen, Georg Auburger, Suzana Gispert, Mekhman Azizov, Isabel Lastres-Becker, Sören Müller, Melanie Vanessa Halbach, Ewa Damrath
Publikováno v:
Neurogenetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
This article is distributed under the terms of the Creative Commons Attribution License.-- et al.
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d4b2667cb52406348e1e3d640ebd2d
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30633
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30633
Autor:
Nazlı Başak, Özgür Ömür, Georg Auburger, Ewa Damrath, Suna Lahut, Suzana Gispert, Melanie Vanessa Heck
Genetic linkage analyses, genome-wide association studies of single nucleotide polymorphisms, copy number variation surveys, and mutation screenings found the human chromosomal 12q24 locus, with the genes SH2B3 and ATXN2 in its core, to be associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebb641421e61f83bfd8105ba6795386
https://europepmc.org/articles/PMC4058736/
https://europepmc.org/articles/PMC4058736/
Autor:
Fabian Afonso-Grunz, Sören Müller, Adam M. Zawada, Peter Winter, Ina Koch, Lukas Rycak, Ewa Damrath, Jessica Scheider, Juliane Schmäh, Günter Kahl, Björn Rotter
Publikováno v:
Database: The Journal of Biological Databases and Curation
Alternative polyadenylation (APA) is a widespread mechanism that contributes to the sophisticated dynamics of gene regulation. Approximately 50% of all protein-coding human genes harbor multiple polyadenylation (PA) sites; their selective and combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7dca73d5838bf3ded87cb2c453af5f
https://mediatum.ub.tum.de/1319899
https://mediatum.ub.tum.de/1319899
Autor:
Ewa Damrath, Georg Auburger, Franca di Summa, Sabrina Zeddies, Daphne C. Thijssen-Timmer, Laura Gutierrez, Marjolein Meinders, Marieke von Lindern, Svitlana Podliesna
Publikováno v:
Experimental Hematology. 41:S68
Autor:
Melanie Vanessa Halbach, Ewa Damrath, Tanja Stehning, Georg Auburger, Michael Walter, Suzana Gispert
Publikováno v:
Cerebellum (London, England)
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disorder with preferential affection of Purkinje neurons, which are known as integrators of calcium currents. The expansion of a polyglutamine (polyQ) domain