In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

Autor: Sharon R Lewin, Jori Symons, Ewa Czuba-Wojnilowicz, Frank Caruso, Christina Cortez-Jugo, Paula M. Cevaal, Abdalla Ali

Publikováno v: ACS Nano. 15:3736-3753

T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, and inflammation, making them attractive targets for the treatment and prevention of diseases. Over recent years, the adv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::400acc5f4fa61bfc4a30c9fcefad1d60
https://doi.org/10.1021/acsnano.0c09514

Metal–Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles

Autor: Francesca Cavalieri, Agata Glab, Frank Caruso, Jianhua Li, Yingjie Hu, Jingqu Chen, Jiajing Zhou, Joseph J. Richardson, Ewa Czuba-Wojnilowicz, Yi Ju, Zhixing Lin

Publikováno v: ACS Nano. 13:11653-11664

The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central issues for biomedical applications. However, the endosomal entrapment of NPs typically results in the degradation of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6876f5f20a2e5a7c90c790992b433ae0
https://doi.org/10.1021/acsnano.9b05521

pH-Responsive Transferrin-pHlexi Particles Capable of Targeting Cells in Vitro

Autor: Shenglin Yang, Georgina K. Such, Laura I. Selby, Adelene S. M. Wong, Rebecca Y. Hodgetts, Angus P. R. Johnston, Kristofer I. Cupic, Moore Z. Chen, Daniel Yuen, Ewa Czuba

Publikováno v: ACS Macro Letters. 6:315-320

Targeting nanoparticles to specific cellular receptors has the potential to deliver therapeutic compounds to target sites while minimizing side effects. To this end, we have conjugated a targeting protein, holo-transferrin (holo-Tf), to pH-responsive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03fc38c48908dd0f5a2489d355ce1fcd
https://doi.org/10.1021/acsmacrolett.7b00044

Distribution of particles in human stem cell-derived 3D neuronal cell models: effect of particle size, charge, and density

Autor: Francesca Cavalieri, Frank Caruso, Serena Viventi, Mirella Dottori, Ewa Czuba-Wojnilowicz, Sara Miellet, Christina Cortez-Jugo, Agata Glab

Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to date. One of the main reasons for the limited clinical outcomes of new drug formulations is the lack of appropriate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd35f9a66b0c9b9fd4330934728a233
https://hdl.handle.net/2108/308184

Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells

Autor: Katrina A. Jolliffe, Ewa Czuba, Sébastien Perrier, Angus P. R. Johnston, Sylvain Catrouillet, Moore Z. Chen, Johannes C. Brendel, Joaquin Sanchis, Cameron J. Nowell, Benjamin M. Long

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (51), pp.16678-16682. ⟨10.1002/anie.201808543⟩

The properties and structures of viruses are directly related to the three-dimensional structure of their capsid proteins, which arises from a combination of hydrophobic and supramolecular interactions, such as hydrogen bonds. The design of synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21122dd492077c6a1625193e0455c22b
https://hal.archives-ouvertes.fr/hal-01990849