Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Ewa Chojnacka-Wójcik"'
Autor:
Tomasz Lenda, Agnieszka Nikiforuk, Ryszard Bugno, Beata Duszyńska, Ewa Tatarczyńska, Maria H. Paluchowska, Ewa Chojnacka-Wójcik
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:7116-7125
New, flexible (7, 9, 11 and 13) and rigid (8, 10, 12 and 14) imides with a 1-(m-trifluorophenyl)piperazine fragment and a tetramethylene or a 1e,4e-cyclohexylene spacer, respectively, showed very high affinity (K(i)=0.3-34 nM) and agonistic in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13973da2d599fdc2f2b08efbe3b8e52
https://doi.org/10.1016/j.bmc.2007.07.029
https://doi.org/10.1016/j.bmc.2007.07.029
Autor:
Magdalena Sowa, Katarzyna Stachowicz, Andrzej Pilc, Ewa Chojnacka-Wójcik, Krystyna Gołembiowska, Gabriel Nowak
Publikováno v:
Neuropharmacology. 53:741-748
The purpose of the present study was to investigate whether the anxiolytic-like action of a selective and brain penetrable group I metabotropic glutamate (mGlu5) receptor antagonist 3-[(2-methyl-1,3-tiazol-4-yl)ethynyl]-pyridine (MTEP) is dependent u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0d985f2bfc1306163e7e3fe97cb376
https://doi.org/10.1016/j.neuropharm.2007.08.002
https://doi.org/10.1016/j.neuropharm.2007.08.002
Autor:
Ewa Tatarczyńska, Maciej Pawłowski, Andrzej J. Bojarski, Agnieszka Nikiforuk, Gilles Subra, Ewa Chojnacka-Wójcik, Paweł Zajdel, Beata Duszyńska, Jean Martinez
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2907-2919
Novel arylpiperazines with N-acylated amino acids, selected on the basis of a preliminary screening of two libraries previously synthesized on SynPhase Lanterns, were prepared in solution and their affinity for 5-HT(1A), 5-HT(2A), and D(2) receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecdb9f702f599cc94465e643f928ee0
https://doi.org/10.1016/j.bmc.2007.02.018
https://doi.org/10.1016/j.bmc.2007.02.018
Autor:
Andrzej J. Bojarski, Maria H. Paluchowska, Ewa Tatarczyńska, Ryszard Bugno, Sijka Charakchieva-Minol, Ewa Chojnacka-Wójcik
Publikováno v:
Archiv der Pharmazie. 339:498-506
The newly synthesized analogs of NAN-190 containing m-Cl and m-CF(3) substituents in the arylpiperazine moiety and their conformationally restricted counterparts showed a very high 5-HT(1A )receptor affinity. In the LLR test, the flexible compounds 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400991ecb0adebbaa485288a0a535be8
https://doi.org/10.1002/ardp.200600009
https://doi.org/10.1002/ardp.200600009
Publikováno v:
Journal of Ethnopharmacology. 107:254-258
Lactucin (1) and its derivatives lactucopicrin (2) and 11β,13-dihydrolactucin (3), which are characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were evaluated for analgesic and sedative properties in mice. The comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39804786e58c60440b442cd788227199
https://doi.org/10.1016/j.jep.2006.03.003
https://doi.org/10.1016/j.jep.2006.03.003
Autor:
Maria H. Paluchowska, Andrzej J. Bojarski, Ewa Chojnacka-Wójcik, Ewa Tatarczyńska, Aleksandra Kłodzińska, Beata Duszyńska
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2293-2303
Starting with the structure of potent 5-HT 1A ligands, that is, MM77 [1-(2-methoxyphenyl)-4-(4-succinimidobutyl)piperazine, 4 ] and its constrained version 5 (MP349), previously obtained in our laboratory, a series of their direct analogues with diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfc2d7797261f00b68e2d1d61b9ad4b
https://doi.org/10.1016/j.bmc.2004.12.041
https://doi.org/10.1016/j.bmc.2004.12.041
Publikováno v:
European Journal of Pharmacology. 498:153-156
We examined the potential anxiolytic-like activity of (-)-N-phenyl-7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxamide (PHCCC), an allosteric modulator of metabotropic glutamate4 receptors (mGlu4), after administration into the basolateral amygdala,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391ff818810fcfc20be394816175b12b
https://doi.org/10.1016/j.ejphar.2004.07.001
https://doi.org/10.1016/j.ejphar.2004.07.001
Publikováno v:
European Journal of Pharmacology. 487:133-142
In the present study, we examined effects of the selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor citalopram, the 5-HT/noradrenaline reuptake inhibitor imipramine, the selective noradrenaline reuptake inhibitor desipramine or the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9473ca87e144a58e3b996092196f1ba4
https://doi.org/10.1016/j.ejphar.2004.01.008
https://doi.org/10.1016/j.ejphar.2004.01.008
Autor:
Joanna M. Wierońska, Andrzej Pilc, Bernadeta Szewczyk, Aleksandra Kłodzińska, A. Palucha, Fabrizio Gasparini, Piotr Brański, Maria Śmiałowska, Ewa Chojnacka-Wójcik
Publikováno v:
Neuropsychopharmacology. 29:514-521
Several lines of evidence indicate that inhibition of the metabotropic glutamate (mGlu) receptor 5 produces anxiolytic-like effects in rodents. Peptide neurotransmitter neuropeptide Y (NPY) produces an anxiolytic effect in rats after intraventricular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607f8b48a27ba6c2141cda14334c0c71
https://doi.org/10.1038/sj.npp.1300322
https://doi.org/10.1038/sj.npp.1300322
Publikováno v:
European Journal of Pharmacology. 471:27-34
In the present paper, we examined the effect of lesions of 5-hydroxytryptamine (5-HT) neurons, produced by p-chloroamphetamine (p-CA; 2 x 10 mg/kg), and the influence of flumazenil (Ro 15-1788, 10 mg/kg), a benzodiazepine receptor antagonist, on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9887d3fa7ed6cd0c85a100ed94fcbf6d
https://doi.org/10.1016/s0014-2999(03)01814-4
https://doi.org/10.1016/s0014-2999(03)01814-4