Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ewa Budzynski"'
Autor:
Nicholas Buss, Lisa Lanigan, Jillynne Zeller, Derek Cissell, Monica Metea, Eric Adams, Mikayla Higgins, Kwi Hye Kim, Ewa Budzynski, Lin Yang, Ye Liu, Mark Butt, Olivier Danos, Michele Fiscella
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 342-354 (2022)
Recent studies in non-human primates administered recombinant adeno-associated viruses (rAAVs) have shown lesions in the dorsal root ganglia (DRG) of unknown pathogenesis. In this study, rAAV9s manufactured using different purification methods alongs
Externí odkaz:
https://doaj.org/article/e6260f18b2164dac9c66ce4a76f074bc
Autor:
Claes Bavik, Susan Hayes Henry, Yan Zhang, Kyoko Mitts, Tim McGinn, Ewa Budzynski, Andriy Pashko, Kuo Lee Lieu, Sheng Zhong, Bruce Blumberg, Vladimir Kuksa, Mark Orme, Ian Scott, Ahmad Fawzi, Ryo Kubota
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124940 (2015)
Increased exposure to blue or visible light, fluctuations in oxygen tension, and the excessive accumulation of toxic retinoid byproducts places a tremendous amount of stress on the retina. Reduction of visual chromophore biosynthesis may be an effect
Externí odkaz:
https://doaj.org/article/02677452c2e0448ba2e9f9dc6d8a6375
Autor:
Lin Yang, SunJung Kim, Louis Gardner, Ewa Budzynski, Jonathan D. Cooper, Sophie H. Wang, Michele Fiscella, Timothy A. Poole, Olivier Danos, Nicholas Buss, Kwi Hye Kim, Mikayla Higgins, Hemanth R. Nelvagal
Publikováno v:
Molecular Genetics and Metabolism. 132:S21
Autor:
Jeffrey D. Chulay, Jim Peterson, Guo-jie Ye, William W. Hauswirth, Nader Sheibani, Shannon E. Boye, Sanford L. Boye, Ewa Budzynski, Zafer Gurel, T Michael Nork, Peter Sonnentag
Publikováno v:
Human Gene Therapy. 27:72-82
Adeno-associated viral (AAV) vectors containing cone-specific promoters have rescued cone photoreceptor function in mouse and dog models of achromatopsia, but cone-specific promoters have not been optimized for use in primates. Using AAV vectors admi
Autor:
Jonathan Stoddard, Martha Neuringer, Kellie Howard, James N. Ver Hoeve, Jeffrey D. Chulay, Alok K. Sharma, Ewa Budzynski, Peter Sonnentag, Guo-jie Ye, David R. Knop, Trevor J. McGill, Paul E. Miller
Publikováno v:
Human Gene Therapy Clinical Development. 26:165-176
Applied Genetic Technologies Corporation is developing rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus (rAAV) vector for treatment of X-linked retinoschisis (XLRS), an inherited retinal disease characterized by splitting (schisis) of retinal l
Autor:
Roberto Calcedo, Paul E. Miller, Jeffrey D. Chulay, James N. Ver Hoeve, David R. Knop, Ewa Budzynski, Guo-jie Ye, Alok K. Sharma, Leia M. Smith, Paulette M. Robinson, William W. Hauswirth, Chantelle Gaskin, Peter Sonnentag, T Michael Nork, Tara Arndt
Publikováno v:
Human Gene Therapy Clinical Development.
Applied Genetic Technologies Corporation (AGTC) is developing rAAV2tYF-PR1.7-hCNGB3, a recombinant adeno-associated viral (rAAV) vector expressing the human CNGB3 gene, for treatment of achromatopsia, an inherited retinal disorder characterized by ma
Autor:
Peter Sonnentag, William W. Hauswirth, James N. Ver Hoeve, Savitri Mandapati, Roberto Calcedo, Ewa Budzynski, Leslie E McPherson, Jeffrey D. Chulay, David R. Knop, Paulette M. Robinson, Tara Arndt, Guo-jie Ye, Leia M. Smith, T Michael Nork, Paul E. Miller
Publikováno v:
Human Gene Therapy Clinical Development.
Applied Genetic Technologies Corporation (AGTC) is developing rAAV2tYF-PR1.7-hCNGB3, a recombinant adeno-associated virus (rAAV) vector expressing the human CNGB3 gene, for treatment of achromatopsia, an inherited retinal disorder characterized by ma
Publikováno v:
Current Eye Research. 35:510-518
Purpose: Transient changes in intraretinal oxygen tension (PO 2 ) in response to light stimuli were studied in order to understand the dynamics of light-evoked changes in photoreceptor oxidative metabolism. Methods: PO 2 changes during illumination w
Autor:
Ewa Budzynski, James N. VerHoeve, Peter Sonnentag, T Michael Nork, Leslie E McPherson, Jeffrey D. Chulay, Paul E. Miller, Guo-jie Ye
Publikováno v:
Molecular Therapy. 23
Both AAV2tYF-hCNGB3 and AAV5-hCNGB3 were well tolerated after subretinal injection in in NHPs at a dose level of 4 × 10^10 or 4 × 10^11 vg/eye. Test article related findings included dose-dependent ocular inflammation that resolved by Study Week 12
Autor:
Ewa Budzynski, Ian M. Scott, Mark W. Orme, Susan Hayes Henry, Ahmad Fawzi, Vladimir A. Kuksa, Kyoko Mitts, Kuo Lee Lieu, Sheng Zhong, Andriy Pashko, Ryo Kubota, Yan Zhang, Bruce Blumberg, Claes Bavik, Tim McGinn
Publikováno v:
PLoS ONE
Bavik, C; Henry, SH; Zhang, Y; Mitts, K; McGinn, T; Budzynski, E; et al.(2015). Visual cycle modulation as an approach toward preservation of retinal integrity. PLoS ONE, 10(5). doi: 10.1371/journal.pone.0124940. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/86q3j2nv
PLoS ONE, Vol 10, Iss 5, p e0124940 (2015)
PloS one, vol 10, iss 5
Bavik, C; Henry, SH; Zhang, Y; Mitts, K; McGinn, T; Budzynski, E; et al.(2015). Visual cycle modulation as an approach toward preservation of retinal integrity. PLoS ONE, 10(5). doi: 10.1371/journal.pone.0124940. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/86q3j2nv
PLoS ONE, Vol 10, Iss 5, p e0124940 (2015)
PloS one, vol 10, iss 5
© 2015 Bavik et al. Increased exposure to blue or visible light, fluctuations in oxygen tension, and the excessive accumulation of toxic retinoid byproducts places a tremendous amount of stress on the retina. Reduction of visual chromophore biosynth