Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ewa Bomba-Warczak"'
Autor:
Carlos Cardanho-Ramos, Rúben Alves Simões, Yi-Zhi Wang, Andreia Faria-Pereira, Ewa Bomba-Warczak, Katleen Craessaerts, Marco Spinazzi, Jeffrey N. Savas, Vanessa A. Morais
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109136- (2024)
Summary: In neurons, it is commonly assumed that mitochondrial replication only occurs in the cell body, after which the mitochondria must travel to the neuron’s periphery. However, while mitochondrial DNA replication has been observed to occur awa
Externí odkaz:
https://doaj.org/article/8d5d140180a74cc88ceb68b53d5521cb
Autor:
Miguel A. Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R. Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A. Rutherford, Rick A. Friedman, Jeffrey N. Savas
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104803- (2022)
Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in t
Externí odkaz:
https://doaj.org/article/2d83c1d5d98a4ed9a50479488748c93e
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Autor:
Ewa Bomba-Warczak, Jason D. Vevea, Joel M. Brittain, Annette Figueroa-Bernier, William H. Tepp, Eric A. Johnson, Felix L. Yeh, Edwin R. Chapman
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1974-1987 (2016)
Recent reports suggest that botulinum neurotoxin (BoNT) A, which is widely used clinically to inhibit neurotransmission, can spread within networks of neurons to have distal effects, but this remains controversial. Moreover, it is not known whether o
Externí odkaz:
https://doaj.org/article/c4b773d1275a4d9899ec5b9f68f3c5a1
Autor:
Derek Walsh, Jeffrey N. Savas, Ewa Bomba-Warczak, Himanshu Kharkwal, Sofia V. Zaichick, Vladimir Jovasevic, DongHo Kim, Gregory A. Smith, Duncan W. Wilson, Patricia J. Sollars, Gary E. Pickard, Caitlin E. Pegg
Publikováno v:
Nature. 599:662-666
Neurotropic alphaherpesviruses initiate infection in exposed mucosal tissues and, unlike most viruses, spread rapidly to sensory and autonomic nerves where life-long latency is established1. Recurrent infections arise sporadically from the peripheral
Autor:
Ewa Bomba-Warczak, Jeffrey N. Savas
Publikováno v:
Trends in cell biology. 32(8)
Intracellular long-lived proteins (LLPs) provide structural support for several highly stable protein complexes and assemblies that play essential roles in ensuring cellular homeostasis and function. Recently, mitochondrial long-lived proteins (mt-LL
Publikováno v:
Journal of Cell Biology. 220
Long-lived proteins (LLPs) have recently emerged as vital components of intracellular structures whose function is coupled to long-term stability. Mitochondria are multifaceted organelles, and their function hinges on efficient proteome renewal and r
Autor:
Laith Ali, Jeffrey N. Savas, Tamara Basta, Anis Contractor, Huan Bao, Ewa Bomba-Warczak, Samuel N. Smukowski, Christelle Guillermier, Takashi Saito, Garry Morgan, Charlotte C. M. Castillon, Matthew L. Steinhauser, Arun Upadhyay, Toshihiro Nomura, Edwin R. Chapman, Timothy J. Hark, Nalini R. Rao, Michael H. B. Stowell, Eileen T. O'Toole, Takaomi C. Saido
Publikováno v:
Cell Syst
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaadf736b2d12299385f4ef804e35e7d
https://europepmc.org/articles/PMC7897324/
https://europepmc.org/articles/PMC7897324/
Autor:
Caitlin E, Pegg, Sofia V, Zaichick, Ewa, Bomba-Warczak, Vladimir, Jovasevic, DongHo, Kim, Himanshu, Kharkwal, Duncan W, Wilson, Derek, Walsh, Patricia J, Sollars, Gary E, Pickard, Jeffrey N, Savas, Gregory A, Smith
Publikováno v:
Nature. 599(7886)
Neurotropic alphaherpesviruses initiate infection in exposed mucosal tissues and, unlike most viruses, spread rapidly to sensory and autonomic nerves where life-long latency is established
Autor:
Avtar Roopra, Robert C. Piper, Michael H. B. Stowell, Tabitha A. Peterson, Chantell S. Evans, Jeffrey N. Savas, Ewa Bomba-Warczak, Robert A. Pearce, Emma T. Watson, Tamara Basta, David A. Ruhl, Trina Basu, Edwin R. Chapman, Alyssa Frelka, Mazdak M. Bradberry, Joseph S. Briguglio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and ins