Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ewa Biala"'
Autor:
Paula Michalak, Julita Piasecka, Barbara Szutkowska, Ryszard Kierzek, Ewa Biala, Walter N. Moss, Elzbieta Kierzek
Publikováno v:
Viruses, Vol 13, Iss 3, p 525 (2021)
The functionality of RNA is fully dependent on its structure. For the influenza A virus (IAV), there are confirmed structural motifs mediating processes which are important for the viral replication cycle, including genome assembly and viral packagin
Externí odkaz:
https://doaj.org/article/5c1ae760fe7f41beb14aede7b3bf1ba8
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163575 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0142139.].
Externí odkaz:
https://doaj.org/article/c3c603e5559549b998797f011c9c99b7
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142139 (2015)
Antisense oligonucleotides have been studied for many years as a tool for gene silencing. One of the most difficult cases of selective RNA silencing involves the alleles of single nucleotide polymorphisms, in which the allele sequence is differentiat
Externí odkaz:
https://doaj.org/article/db2c84a32aff4cde9ee3e7ddedb7e0d1
Autor:
Julita Kesy, Paula Michalak, Elzbieta Lenartowicz, Ewa Biala, Ryszard Kierzek, Elzbieta Kierzek, Walter N. Moss, Barbara Szutkowska, Marta Soszynska-Jozwiak
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports
Scientific Reports
Influenza virus causes seasonal epidemics and dangerous pandemic outbreaks. It is a single stranded (−)RNA virus with a segmented genome. Eight segments of genomic viral RNA (vRNA) form the virion, which are then transcribed and replicated in host
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
This study focused on determining design rules for gapmer-type antisense oligonucleotides (ASOs), that can differentiate cleavability of two SNP variants of RNA in the presence of ribonuclease H based on the mismatch type and position in the heterodu
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142139 (2015)
PLoS ONE
PLoS ONE
Antisense oligonucleotides have been studied for many years as a tool for gene silencing. One of the most difficult cases of selective RNA silencing involves the alleles of single nucleotide polymorphisms, in which the allele sequence is differentiat
Publikováno v:
Biophysical Chemistry. 97:243-249
The ribonucleic acids (RNA) form highly folded structures, which behind the helical fragments contain several secondary and tertiary structural motives. All of them have an influence on thermodynamic stability of the RNA. The 5'- and 3'-dangling ends
Publikováno v:
Tetrahedron. 56:1475-1484
The d - and l -RNA nonamers of the sequence r(GCUUCGGC)T have been synthesised for X-ray crystallographic purposes. In vitro digestion of the unnatural optical antipode by snake venom phosphodiesterase I takes place at an approximately 1800-fold slow
Publikováno v:
Nucleic Acids Research. 25:4589-4598
Structures of r(CGCGCG)2 and 24-O-Me(CGCGCG)2 have been determined by NMR spectroscopy under low salt conditions. All protons and phosphorus nuclei resonances have been assigned. Signals of H54/544 have been assigned stereospecifically. All 3 JH,H an
Publikováno v:
Nucleosides and Nucleotides. 15:477-488
Results of PM3 semiempirical calculation revealed that energy and hydrogen bonds geometry of 1-methyl-5-fluoro-uracil and -cytosine base-pairs with 9-methyl-adenine and -guanine respectively are virtually the same as for the natural bases. Analysis o