Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ewa Aladowicz"'
Autor:
Eleanor O’Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley, Zoë S. Walters
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic differentiation. Despite intensive treatment, 5-year survival for patients with advanced disea
Externí odkaz:
https://doaj.org/article/b09403c2536c486da89cc39dfaf84132
Autor:
Christopher I. Milton, Joanna Selfe, Ewa Aladowicz, Stella Y. K. Man, Carolina Bernauer, Edoardo Missiaglia, Zoë S. Walters, Susanne A. Gatz, Anna Kelsey, Melanie Generali, Gary Box, Melanie Valenti, Alexis deHaven‐Brandon, David Galiwango, Angela Hayes, Matthew Clarke, Elisa Izquierdo, David Gonzalez De Castro, Florence I. Raynaud, Vladimir Kirkin, Janet M. Shipley
Publikováno v:
Molecular Oncology, Vol 16, Iss 6, Pp 1272-1289 (2022)
Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought
Externí odkaz:
https://doaj.org/article/5b496d1e847c44f09cabb855a8b74715
Autor:
Susanne A. Gatz, Ewa Aladowicz, Michela Casanova, Julia C. Chisholm, Pamela R. Kearns, Simone Fulda, Birgit Geoerger, Beat W. Schäfer, Janet M. Shipley
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease
Externí odkaz:
https://doaj.org/article/4fc4f77910684cc7bfb2bc64c293d211
Autor:
Zoë S. Walters, Ewa Aladowicz, Barbara Villarejo-Balcells, Gary Nugent, Joanna L. Selfe, Paul Eve, Julian Blagg, Olivia Rossanese, Janet Shipley
Publikováno v:
Cancers, Vol 13, Iss 7, p 1734 (2021)
Histone demethylases are epigenetic modulators that play key roles in regulating gene expression related to many critical cellular functions and are emerging as promising therapeutic targets in a number of tumor types. We previously identified histon
Externí odkaz:
https://doaj.org/article/d23553ea46cb40ee90698360483c67db
Autor:
Ewa Aladowicz, Letizia Granieri, Federica Marocchi, Simona Punzi, Giuseppina Giardina, Pier Francesco Ferrucci, Giovanni Mazzarol, Maria Capra, Giuseppe Viale, Stefano Confalonieri, Sara Gandini, Fiorenza Lotti, Luisa Lanfrancone
Publikováno v:
Cancers, Vol 12, Iss 11, p 3366 (2020)
Metastases are the primary cause of cancer-related deaths. The underlying molecular and biological mechanisms remain, however, elusive, thus preventing the design of specific therapies. In melanomas, the metastatic process is influenced by the acquis
Externí odkaz:
https://doaj.org/article/ab6c40d547fc485b886e220251986af3
Autor:
Olivia Ruhen, Nathalie S.M. Lak, Janine Stutterheim, Sara G. Danielli, Mathieu Chicard, Yasmine Iddir, Alexandra Saint-Charles, Virginia Di Paolo, Lucia Tombolan, Susanne A. Gatz, Ewa Aladowicz, Paula Proszek, Sabri Jamal, Reda Stankunaite, Deborah Hughes, Paul Carter, Elisa Izquierdo, Ajla Wasti, Julia C. Chisholm, Sally L. George, Erika Pace, Louis Chesler, Isabelle Aerts, Gaelle Pierron, Sakina Zaidi, Olivier Delattre, Didier Surdez, Anna Kelsey, Michael Hubank, Paolo Bonvini, Gianni Bisogno, Angela Di Giannatale, Gudrun Schleiermacher, Beat W. Schäfer, Godelieve A.M. Tytgat, Janet Shipley
Publikováno v:
JCO precision oncology. 6
PURPOSE Rhabdomyosarcomas (RMS) are rare neoplasms affecting children and young adults. Efforts to improve patient survival have been undermined by a lack of suitable disease markers. Plasma circulating tumor DNA (ctDNA) has shown promise as a potent
Autor:
Elisa Izquierdo, Y. K. Stella Man, Angela Hayes, Zoë S Walters, Susanne A. Gatz, Christopher I Milton, Ewa Aladowicz, Melanie Valenti, David Gonzalez de Castro, Melanie Generali, Matthew Clarke, Anna Kelsey, David Galiwango, Edoardo Missiaglia, Vladimir Kirkin, Joanna Selfe, Carolina Bernauer, Alexis de Haven-Brandon, Gary Box, Florence I. Raynaud, Janet Shipley
Publikováno v:
Milton, C I, Selfe, J, Aladowicz, E, Man, Y K S, Bernauer, C, Missiaglia, E, Walters, Z S, Gatz, S A, Kelsey, A, Generali, M, Box, G, Valenti, M, Haven-Brandon, A, Galiwango, D, Hayes, A, Clarke, M, Izquierdo, E, Gonzalez De Castro, D, Raynaud, F I, Kirkin, V & Shipley, J M 2021, ' FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion-positive rhabdomyosarcomas ', Molecular oncology . https://doi.org/10.1002/1878-0261.13145
Rhabdomyosarcomas are aggressive pediatric soft-tissue sarcomas and include high-risk PAX3-FOXO1 fusion-gene-positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a7f7aa64de33c3bacbc46e957aeca2
https://eprints.soton.ac.uk/453037/
https://eprints.soton.ac.uk/453037/
Autor:
null Christopher I Milton, null Joanna Selfe, null Ewa Aladowicz, null Y.K. Stella Man, null Carolina Bernauer, null Edoardo Missiaglia, null Zoë S Walters, null Susanne A Gatz, null Anna Kelsey, null Melanie Generali, null Gary Box, null Melanie Valenti, null Alexis Haven‐Brandon, null David Galiwango, null Angela Hayes, null Matthew Clarke, null Elisa Izquierdo, null David Gonzalez De Castro, null Florence I. Raynaud, null Vladimir Kirkin, null Janet M Shipley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf2b3d61501b398b994e915a272bbdc
https://doi.org/10.1002/1878-0261.13145/v2/response1
https://doi.org/10.1002/1878-0261.13145/v2/response1
Autor:
Barbara Villarejo-Balcells, Paul D. Eve, Zoë S. Walters, Julian Blagg, Gary Nugent, Olivia W. Rossanese, Joanna Selfe, Ewa Aladowicz, Janet Shipley
Publikováno v:
Cancers
Volume 13
Issue 7
Cancers, Vol 13, Iss 1734, p 1734 (2021)
Volume 13
Issue 7
Cancers, Vol 13, Iss 1734, p 1734 (2021)
Simple Summary Rhabdomyosarcomas (RMS) are soft tissue sarcomas predominant in the pediatric age range. Current standard multi-modal treatments can result in severe life-long side-effects across all subtypes and dismal outcomes in RMS patients classi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2c178b147944b58040a593131699f
https://eprints.soton.ac.uk/449294/
https://eprints.soton.ac.uk/449294/
Publikováno v:
Pediatric bloodcancer. 66(9)
Background Ewing sarcoma and desmoplastic small round cell tumors (DSRCT) are rare and clinically aggressive sarcomas usually characterized by oncogenic fusion proteins involving EWS. Emerging studies of Ewing sarcoma have demonstrated EWS-FLI1-drive