Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ewa A. Okely"'
Publikováno v:
Genetics
Jackson, A, Okely, E A & Leach, D R F 2014, ' Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities ', Genetics, vol. 198, no. 2, pp. 509-517 . https://doi.org/10.1534/genetics.114.168245
Jackson, A, Okely, E A & Leach, D R F 2014, ' Expansion of CAG repeats in Escherichia coli is controlled by single-strand DNA exonucleases of both polarities ', Genetics, vol. 198, no. 2, pp. 509-517 . https://doi.org/10.1534/genetics.114.168245
The expansion of CAG·CTG repeat tracts is responsible for several neurodegenerative diseases, including Huntington disease and myotonic dystrophy. Understanding the molecular mechanism of CAG·CTG repeat tract expansion is therefore important if we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a780b8f67272b5f263edc40efa635f
http://europepmc.org/articles/PMC4196609
http://europepmc.org/articles/PMC4196609
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22582-22586
Approximately half the human genome is composed of repetitive DNA sequences classified into microsatellites, minisatellites, tandem repeats, and dispersed repeats. These repetitive sequences have coevolved within the genome but little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9ab110d038e3df4dbca8acbbee8995
https://doi.org/10.1073/pnas.1012906108
https://doi.org/10.1073/pnas.1012906108
Publikováno v:
Journal of Biological Chemistry. 272:19819-19826
The sbcC and sbcD genes mediate palindrome inviability in Escherichia coli. The sbcCD operon has been cloned into the plasmid pTrc99A under the control of the strong trc promoter and introduced into a strain carrying a chromosomal deletion of sbcCD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1d224f10d38f5a3f5cdc421ffa7307
https://doi.org/10.1074/jbc.272.32.19819
https://doi.org/10.1074/jbc.272.32.19819
Publikováno v:
Scopus-Elsevier
The propagation of lambda phages carrying long perfect palindromes has been compared with that of phages carrying imperfect palindromes with small regions of central asymmetry. The perfect palindromes confer a more deleterious phenotype than those wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8c8ab4de555bb8735ece2c3e81f7fa
https://doi.org/10.1093/genetics/133.2.143
https://doi.org/10.1093/genetics/133.2.143
Autor:
Lucy H. Jones, David R. F. Leach, Frédéric Lincker, John K. Blackwood, Martin White, John K. Eykelenboom, Ewa A. Okely, Elise Darmon
Publikováno v:
Darmon, E, Eykelenboom, J K, Lincker, F, Jones, L, White, M, Okely, E, Blackwood, J K & Leach, D R 2010, ' E. coli SbcCD and RecA Control Chromosomal Rearrangement Induced by an Interrupted Palindrome ', Molecular Cell, vol. 39, no. 1, pp. 59-70 . https://doi.org/10.1016/j.molcel.2010.06.011
Molecular Cell
Molecular Cell
Summary Survival and genome stability are critical characteristics of healthy cells. DNA palindromes pose a threat to genome stability and have been shown to participate in a reaction leading to the formation of inverted chromosome duplications cente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92288d1ed1be726f26123668bc8989e
https://www.pure.ed.ac.uk/ws/files/8543272/E._coli_SbcCD_and_RecA_Control_Chromosomal.pdf
https://www.pure.ed.ac.uk/ws/files/8543272/E._coli_SbcCD_and_RecA_Control_Chromosomal.pdf
Publikováno v:
Molecular cell. 29(5)
Long DNA palindromes are sites of genome instability (deletions, amplification, and translocations) in both prokaryotic and eukaryotic cells. In Escherichia coli, genetic evidence has suggested that they are sites of DNA cleavage by the SbcCD complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da461a68827829024b43f8dc43060f0e
https://pubmed.ncbi.nlm.nih.gov/18342610
https://pubmed.ncbi.nlm.nih.gov/18342610
Publikováno v:
Molecular microbiology. 26(3)
We report here that homologous recombination functions are required for the viability of Escherichia coli cells maintaining a 240 bp chromosomal inverted repeat (palindromic) sequence. Wild-type cells can successfully replicate this palindrome but re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f33340e1d863d7bfc14b454b38c688e
https://pubmed.ncbi.nlm.nih.gov/9402028
https://pubmed.ncbi.nlm.nih.gov/9402028
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 8, p e6542 (2009)
Wardrope, L, Okely, E & Leach, D 2009, ' Resolution of Joint Molecules by RuvABC and RecG Following Cleavage of the Escherichia coli Chromosome by EcoKI ', PLoS ONE, vol. 4, no. 8, e6542, pp.-. https://doi.org/10.1371/journal.pone.0006542
PLoS ONE, Vol 4, Iss 8, p e6542 (2009)
Wardrope, L, Okely, E & Leach, D 2009, ' Resolution of Joint Molecules by RuvABC and RecG Following Cleavage of the Escherichia coli Chromosome by EcoKI ', PLoS ONE, vol. 4, no. 8, e6542, pp.-. https://doi.org/10.1371/journal.pone.0006542
DNA double-strand breaks can be repaired by homologous recombination involving the formation and resolution of Holliday junctions. In Escherichia coli, the RuvABC resolvasome and the RecG branch-migration enzyme have been proposed to act in alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13744bd48a62084e89eddd321ec5ead7
https://doi.org/10.1371/journal.pone.0006542
https://doi.org/10.1371/journal.pone.0006542
Publikováno v:
Molecular microbiology. 4(4)
Summary We have shown that a mini-Mu can transpose into itself in vivo to generate a circle containing only transposon sequences. This deletion-inversion product, which has previously been observed in vitro, is formed by non-replicative transposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a8ed292be7f5de604e0a5cbacc41a5
https://pubmed.ncbi.nlm.nih.gov/2161987
https://pubmed.ncbi.nlm.nih.gov/2161987