Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ewa A. Bienkiewicz"'
Publikováno v:
ACS Omega, Vol 5, Iss 39, Pp 25029-25035 (2020)
Externí odkaz:
https://doaj.org/article/4891be44636e411581e091eee26dcc6d
Autor:
Tiago Veltri, Guilherme A. P. de Oliveira, Ewa A. Bienkiewicz, Fernando L. Palhano, Mayra de A. Marques, Adolfo H. Moraes, Jerson L. Silva, Martha M. Sorenson, Jose R. Pinto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible
Externí odkaz:
https://doaj.org/article/24f869ff88314b1487e847a605d31809
Fusicoccin A (FC) is a fungal phytotoxin that stabilizes protein–protein interactions (PPIs) between 14-3-3 adapter proteins and their phosphoprotein interaction partners. In recent years, FC has emerged as an important chemical probe of human 14-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78786273df2985af98eb92024f916ed9
https://doi.org/10.26434/chemrxiv.12052869.v1
https://doi.org/10.26434/chemrxiv.12052869.v1
Publikováno v:
Journal of Alzheimer's disease : JAD. 55(3)
Background Alzheimer's disease (AD) is the leading cause of dementia, and as its prevalence increases, so does its detrimental impact on society. The currently available therapies have limited efficacy, leaving AD patients on an irrevocably fatal pat
Autor:
Tiago, Veltri, Guilherme A P, de Oliveira, Ewa A, Bienkiewicz, Fernando L, Palhano, Mayra de A, Marques, Adolfo H, Moraes, Jerson L, Silva, Martha M, Sorenson, Jose R, Pinto
Publikováno v:
Scientific Reports
The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible to higher
Autor:
Ronald M. Evans, Ozan S. Kumru, Ewa A. Bienkiewicz, Michael Blaber, Xue Xia, Ling Li, Connie A. Tenorio, Annette R. Atkins, Sachiko I. Blaber, Jae Myoung Suh, David M. Ornitz, C. Russell Middaugh, Michael Downes
Publikováno v:
Journal of pharmaceutical sciences. 105(12)
Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S1
Autor:
Ewa A. Bienkiewicz, Xiao-Qian Fang, Melissa Pflueger, Shuang-Xiu Lin, Bradley R. Groveman, Xian-Min Yu, Shuang Feng
Publikováno v:
FEBS Journal. 279:20-28
Src family kinases (SFKs) play critical roles in the regulation of many cellular functions by growth factors, G-protein-coupled receptors and ligand-gated ion channels. Recent data have shown that SFKs serve as a convergent point of multiple signalin
Autor:
Lisa A. Compton, Thomas M. Asbury, Justin R. Grubich, Ewa A. Bienkiewicz, Fang Wang, P. Bryant Chase, Goran Mihajlovic, Victor F. Miller, Nicolas M. Brunet
Publikováno v:
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
Familial hypertrophic cardiomyopathy (FHC) is a disease of cardiac sarcomeres. To identify molecular mechanisms underlying FHC pathology, functional and structural differences in three FHC-related mutations in recombinantα-Tm (V95A, D175N, and E180G
Autor:
Ewa A. Bienkiewicz, Bradley R. Groveman, Sheng Xue, Vedrana Marin, Mohammad K. Ali, Xian-Min Yu, Jindong Xu
Publikováno v:
FEBS Journal. 278:643-653
Previous studies demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and/or binding of the SH2 kinase linker to the SH3 domain, lock the molecules in
Autor:
Ewa A. Bienkiewicz, Shuang-Xiu Lin, Haifa Qiao, Bradley R. Groveman, Vedrana Marin, Jindong Xu, Raed Rizkallah, Xian-Min Yu, Xiao-Qian Fang, Myra H. Hurt, Mohammad K. Ali
Publikováno v:
Protein Expression and Purification. 74:289-297
Neuronal Src (n-Src) is an alternative isoform of Src kinase containing a 6-amino acid insert in the SH3 domain that is highly expressed in neurons of the central nervous system (CNS). To investigate the function of n-Src, wild-type n-Src, constituti