Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ewa A Bienkiewicz"'
Autor:
Amit Kumar, Rebekah L Bullard, Pritesh Patel, Lea C Paslay, Dipti Singh, Ewa A Bienkiewicz, Sarah E Morgan, Vijayaraghavan Rangachari
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18759 (2011)
Amyloid-β (Aβ) peptide aggregation is known to play a central role in the etiology of Alzheimer's disease (AD). Among various aggregates, low-molecular weight soluble oligomers of Aβ are increasingly believed to be the primary neurotoxic agents re
Externí odkaz:
https://doaj.org/article/b5812ea5adbd470cb224556fe18cc419
Fusicoccin A (FC) is a fungal phytotoxin that stabilizes protein–protein interactions (PPIs) between 14-3-3 adapter proteins and their phosphoprotein interaction partners. In recent years, FC has emerged as an important chemical probe of human 14-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78786273df2985af98eb92024f916ed9
https://doi.org/10.26434/chemrxiv.12052869.v1
https://doi.org/10.26434/chemrxiv.12052869.v1
Publikováno v:
Journal of Alzheimer's disease : JAD. 55(3)
Background Alzheimer's disease (AD) is the leading cause of dementia, and as its prevalence increases, so does its detrimental impact on society. The currently available therapies have limited efficacy, leaving AD patients on an irrevocably fatal pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef72104133a4eec80e7af5804f6d15ff
https://pubmed.ncbi.nlm.nih.gov/27814295
https://pubmed.ncbi.nlm.nih.gov/27814295
Autor:
Tiago, Veltri, Guilherme A P, de Oliveira, Ewa A, Bienkiewicz, Fernando L, Palhano, Mayra de A, Marques, Adolfo H, Moraes, Jerson L, Silva, Martha M, Sorenson, Jose R, Pinto
Publikováno v:
Scientific Reports
The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein. As a result, structure and function of the mutant are more susceptible to higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ad800149ace6f2f6b774f7b88f3a8e2
https://pubmed.ncbi.nlm.nih.gov/28386062
https://pubmed.ncbi.nlm.nih.gov/28386062
Autor:
Ronald M. Evans, Ozan S. Kumru, Ewa A. Bienkiewicz, Michael Blaber, Xue Xia, Ling Li, Connie A. Tenorio, Annette R. Atkins, Sachiko I. Blaber, Jae Myoung Suh, David M. Ornitz, C. Russell Middaugh, Michael Downes
Publikováno v:
Journal of pharmaceutical sciences. 105(12)
Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422b1319f359601b91a431e540e26dfd
https://pubmed.ncbi.nlm.nih.gov/27773526
https://pubmed.ncbi.nlm.nih.gov/27773526
Autor:
Steven Lenhert, Plengchart Prommapan, Nicholas Vafai, Ewa A. Bienkiewicz, Troy W. Lowry, Aubrey Kusi-Appiah, David H. Van Winkle, Hanaa Hariri, Scott M. Stagg
The dynamic self-organization of lipids in biological systems is a highly regulated process that enables the compartmentalization of living systems at micro- and nanoscopic scales. Consequently, quantitative methods for assaying the kinetics of supra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0501fc9a18c20452bb2799f2da001593
https://europepmc.org/articles/PMC4843995/
https://europepmc.org/articles/PMC4843995/
Autor:
Ewa A. Bienkiewicz, Xiao-Qian Fang, Melissa Pflueger, Shuang-Xiu Lin, Bradley R. Groveman, Xian-Min Yu, Shuang Feng
Publikováno v:
FEBS Journal. 279:20-28
Src family kinases (SFKs) play critical roles in the regulation of many cellular functions by growth factors, G-protein-coupled receptors and ligand-gated ion channels. Recent data have shown that SFKs serve as a convergent point of multiple signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::127107a5b8761c187189adc4c70e945c
https://doi.org/10.1111/j.1742-4658.2011.08413.x
https://doi.org/10.1111/j.1742-4658.2011.08413.x
Autor:
Lisa A. Compton, Thomas M. Asbury, Justin R. Grubich, Ewa A. Bienkiewicz, Fang Wang, P. Bryant Chase, Goran Mihajlovic, Victor F. Miller, Nicolas M. Brunet
Publikováno v:
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
Familial hypertrophic cardiomyopathy (FHC) is a disease of cardiac sarcomeres. To identify molecular mechanisms underlying FHC pathology, functional and structural differences in three FHC-related mutations in recombinantα-Tm (V95A, D175N, and E180G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53603cf8f431cde542c0ac02af8f4407
https://doi.org/10.1155/2011/435271
https://doi.org/10.1155/2011/435271
Autor:
Ewa A. Bienkiewicz, Bradley R. Groveman, Sheng Xue, Vedrana Marin, Mohammad K. Ali, Xian-Min Yu, Jindong Xu
Publikováno v:
FEBS Journal. 278:643-653
Previous studies demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and/or binding of the SH2 kinase linker to the SH3 domain, lock the molecules in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::333ba640bb55ed05d4b0e71bdc6cadc9
https://doi.org/10.1111/j.1742-4658.2010.07985.x
https://doi.org/10.1111/j.1742-4658.2010.07985.x
Autor:
Ewa A. Bienkiewicz, Shuang-Xiu Lin, Haifa Qiao, Bradley R. Groveman, Vedrana Marin, Jindong Xu, Raed Rizkallah, Xian-Min Yu, Xiao-Qian Fang, Myra H. Hurt, Mohammad K. Ali
Publikováno v:
Protein Expression and Purification. 74:289-297
Neuronal Src (n-Src) is an alternative isoform of Src kinase containing a 6-amino acid insert in the SH3 domain that is highly expressed in neurons of the central nervous system (CNS). To investigate the function of n-Src, wild-type n-Src, constituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426ad939202acb1dd72ad7ed666e4c76
https://doi.org/10.1016/j.pep.2010.06.004
https://doi.org/10.1016/j.pep.2010.06.004