Výsledky vyhledávání - "Ewa Świderska"

Akademický článek

Autophagy Inhibition with Chloroquine Increased Pro-Apoptotic Potential of New Aziridine-Hydrazide Hydrazone Derivatives against Glioblastoma Cells

Autor: Monika Witusik-Perkowska, Pola Głowacka, Adam M. Pieczonka, Ewa Świderska, Agnieszka Pudlarz, Michał Rachwalski, Julia Szymańska, Magdalena Zakrzewska, Dariusz J. Jaskólski, Janusz Szemraj

Publikováno v: Cells, Vol 12, Iss 14, p 1906 (2023)

Tumor therapy escape due to undesired side effects induced by treatment, such as prosurvival autophagy or cellular senescence, is one of the key mechanisms of resistance that eventually leads to tumor dormancy and recurrence. Glioblastoma is the most

Externí odkaz: https://doaj.org/article/d56baa2b90c24caaaa95650aa5ded912

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Akademický článek

Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels)

Autor: Izabela Szymczak-Pajor, Józef Drzewoski, Ewa Świderska, Justyna Strycharz, Anna Gabryanczyk, Jacek Kasznicki, Marta Bogdańska, Agnieszka Śliwińska

Publikováno v: Pharmaceuticals, Vol 16, Iss 1, p 115 (2023)

Accumulating evidence (mainly from experimental research) suggests that metformin possesses anticancer properties through the induction of apoptosis and inhibition of the growth and proliferation of cancer cells. However, its effect on the enzymes re

Externí odkaz: https://doaj.org/article/9bb8afdd0bb543209d563f005c79013f

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Akademický článek

Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling

Autor: Justyna Strycharz, Adam Wróblewski, Andrzej Zieleniak, Ewa Świderska, Tomasz Matyjas, Monika Rucińska, Lech Pomorski, Piotr Czarny, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska

Publikováno v: Antioxidants, Vol 10, Iss 1, p 101 (2021)

Hypertrophic and hypoxic visceral adipose tissue (VAT) secretes proinflammatory cytokines promoting insulin resistance (IR), prediabetes and type 2 diabetes (T2DM) microRNAs (miRNAs) are markers of metabolic disorders regulating genes critical for e.

Externí odkaz: https://doaj.org/article/f7abb3d2a97b4906b105a1b00c628dc6

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Akademický článek

Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells

Autor: Martyna Wojtala, Arkadiusz Dąbek, Dorota Rybaczek, Agnieszka Śliwińska, Ewa Świderska, Katarzyna Słapek, Assam El-Osta, Aneta Balcerczyk

Publikováno v: Cells, Vol 8, Iss 10, p 1212 (2019)

The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- an

Externí odkaz: https://doaj.org/article/5af3dc55f31541c7ae7705c5134e92b1

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Chronic and Intermittent Hyperglycemia Modulates Expression of Key Molecules of PI3K/AKT Pathway in Differentiating Human Visceral Adipocytes

Autor: Justyna Strycharz, Adam Wróblewski, Józef Drzewoski, Janusz Szemraj, Piotr Czarny, Ewa Świderska, Agnieszka Śliwińska

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7712, p 7712 (2021)

Background: Due to its prominence in the regulation of metabolism and inflammation, adipose tissue is a major target to investigate alterations in insulin action. This hormone activates PI3K/AKT pathway which is essential for glucose homeostasis, cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316d60711467f498c662e28a898d9193

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Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of

Autor: Adam, Wróblewski, Justyna, Strycharz, Ewa, Świderska, Aneta, Balcerczyk, Janusz, Szemraj, Józef, Drzewoski, Agnieszka, Śliwińska

Publikováno v: International Journal of Molecular Sciences

Adipokines secreted by hypertrophic visceral adipose tissue (VAT) instigate low-grade inflammation, followed by hyperglycemia (HG)-related metabolic disorders. The latter may develop with the participation of epigenetic modifications. Our aim was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d942e06a6d126c42530511a6c97ffa2b
https://pubmed.ncbi.nlm.nih.gov/34203452

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Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes

Autor: Janusz Szemraj, Józef Drzewoski, Aneta Balcerczyk, Ewa Świderska, Justyna Strycharz, Agnieszka Śliwińska, Adam Wróblewski

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6964, p 6964 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bec0fd24dee155cf6b313dff9f5d80
https://doi.org/10.3390/ijms22136964

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Autor: Arkadiusz Dąbek, Aneta Balcerczyk, Marta Wojtala, Assam El-Osta, Agnieszka Śliwińska, Katarzyna Słapek, Dorota Rybaczek, Ewa Świderska

Publikováno v: Cells
Cells, Vol 8, Iss 10, p 1212 (2019)
Volume 8
Issue 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81cf021b0a1f49b2a7337a6fc01c818
http://europepmc.org/articles/PMC6829479

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Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes

Autor: Józef Drzewoski, Agnieszka Śliwińska, Ireneusz Majsterek, Beata Brozek-Pluska, Halina Abramczyk, Marta Podolska, Adam Wróblewski, Justyna Strycharz, Marzena Szwed, Ewa Świderska, Janusz Szemraj

Publikováno v: Nutrients, Vol 11, Iss 8, p 1835 (2019)
Nutrients
Volume 11
Issue 8

Disturbances in adipose tissue significantly contribute to the development of metabolic disorders, which are connected with hyperglycemia (HG) and underlain by epigenetics-based mechanisms. Therefore, we aimed to evaluate the effect of hyperglycemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07aa70abbd0e255d2ad7834ddbc1001
https://www.mdpi.com/2072-6643/11/8/1835

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Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders

Autor: Agnieszka Śliwińska, Józef Drzewoski, Justyna Strycharz, Adam Wróblewski, Janusz Szemraj, Karolina Drewniak, Ewa Świderska, Jacek Kasznicki

Publikováno v: Nutrients, Vol 11, Iss 8, p 1872 (2019)
Nutrients

Nowadays, it is well-known that the deregulation of epigenetic machinery is a common biological event leading to the development and progression of metabolic disorders. Moreover, the expression level and actions of leptin, a vast adipocytokine regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cadfd4449fdf77f9605bb2a3d0b73b
https://www.mdpi.com/2072-6643/11/8/1872

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