Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ewa, Marszal"'
Autor:
Maria Gaczynska, Przemyslaw Karpowicz, Christine E Stuart, Malgorzata G Norton, Jeffrey H Teckman, Ewa Marszal, Pawel A Osmulski
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151902 (2016)
α1-Proteinase inhibitor (antitrypsin) is a canonical example of the serpin family member that binds and inhibits serine proteases. The natural metastability of serpins is crucial to carry out structural rearrangements necessary for biological activi
Externí odkaz:
https://doaj.org/article/9d2345f5effb4458b7c0bf04237c4ffa
Publikováno v:
Pharmaceutical Research. 33:1736-1751
Purpose To investigate in vitro the innate immune response to accelerated stress-induced aggregates of intravenous immunoglobulin (IGIV) using a well-defined human cell-line model, and to correlate the innate response to physical properties of the ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ee2aed2c5f4697d8150a7efe1cbc22
https://doi.org/10.1007/s11095-016-1914-4
https://doi.org/10.1007/s11095-016-1914-4
Autor:
Elizabeth Fowler, Ewa Marszal
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3555-3559
Particles in protein therapeutics and concerns for a potential correlation with product immunogenicity are increasingly becoming the focus of recent publications and scientific forums. The consensus of academic, industrial, and regulatory scientists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03975d4d06447aa1e9c29ddfaa4fb01
https://doi.org/10.1002/jps.23243
https://doi.org/10.1002/jps.23243
Autor:
John F. Carpenter, Barry Cherney, Thomas Nikolai, Anthony Lubinecki, Jack A. Ragheb, Jeanne M. Novak, Stacey Ma, Anthony Mire-Sluis, Ewa Marszal, Jan Simak
Publikováno v:
Biologicals. 38:602-611
This meeting was successful in achieving its main goals: (1) summarize currently available information on the origin, detection, quantification and characterization of sub-visible particulates in protein products, available information on their clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::248cfbcb3c13bb9a25d162acf961b3ea
https://doi.org/10.1016/j.biologicals.2010.07.002
https://doi.org/10.1016/j.biologicals.2010.07.002
Autor:
Janice Brown, Silvia H. De Paoli, Yideng Liang, Ewa Marszal, Mikhail V Ovanesov, Jan Simak, Jack A. Ragheb, Christine Stuart, Dean D. Metcalfe, Tsai-Lien Lin, Yamei Gao, Dorothy E. Scott, Yun Bai, Joseph Kotarek
Publikováno v:
Journal of pharmaceutical sciences. 105(3)
Peginesatide (Omontys(®); Affymax, Inc., Cupertino, CA) was voluntarily withdrawn from the market less than a year after the product launch. Although clinical trials had demonstrated the drug to be safe and efficacious, 49 cases of anaphylaxis, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a85bae4fb3133b69be800bc8e9444a
https://pubmed.ncbi.nlm.nih.gov/26886324
https://pubmed.ncbi.nlm.nih.gov/26886324
Aggregation is common in protein drug manufacture, and while the effects of protein particulates are under investigation, many techniques applicable for their characterization have been recently developed. Among the methods available to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee56bed979493a0c7936ad5bda63a58
https://europepmc.org/articles/PMC4012052/
https://europepmc.org/articles/PMC4012052/
Autor:
Pawel A. Osmulski, Jeffrey Teckman, Christine Stuart, Maria Gaczynska, Ewa Marszal, Przemyslaw Karpowicz, Malgorzata G. Norton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0151902 (2016)
PLoS ONE, Vol 11, Iss 3, p e0151902 (2016)
α1-Proteinase inhibitor (antitrypsin) is a canonical example of the serpin family member that binds and inhibits serine proteases. The natural metastability of serpins is crucial to carry out structural rearrangements necessary for biological activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d81a2d885a05290920d478290ffcb5e
https://pubmed.ncbi.nlm.nih.gov/27008547
https://pubmed.ncbi.nlm.nih.gov/27008547
Autor:
William H. Scouten, Ewa Marszal
Publikováno v:
Journal of Molecular Recognition. 9:543-548
Dihydrofolate reductase was synthesized in a batch system in the presence of the affinity ligand methotrexate, bound to various matrices. Two types of gel were used: commercial methotrexate-agarose with pores inaccessible for translation machinery an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f40fe5084e8922303665fdb56608a918
https://doi.org/10.1002/(sici)1099-1352(199634/12)9:5/6<543::aid-jmr298>3.0.co
https://doi.org/10.1002/(sici)1099-1352(199634/12)9:5/6<543::aid-jmr298>3.0.co
Autor:
John F. Cipollo, Zuben E. Sauna, Jack A. Ragheb, Ewa Marszal, Evi Struble, Chava Kimchi-Sarfaty
Publikováno v:
Biophysics for Therapeutic Protein Development ISBN: 9781461443155
The complex three-dimensional structure of therapeutic proteins may be affected by the conditions used for production, purification, handling, and storage. Changes to this structure affect product quality and could impact product safety and effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9861b53e1e265787e79561989054e15d
https://doi.org/10.1007/978-1-4614-4316-2_11
https://doi.org/10.1007/978-1-4614-4316-2_11
Publikováno v:
Journal of Molecular Recognition. 8:151-156
Protein synthesis in an aqueous two-phase system is reported here as a novel type of extractive bioconversion. Translation of BMV RNA was studied using either rabbit reticulocyte lysate or wheat-germ extract in aqueous dextran-PEG systems. Both polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1b7b5e5cef08aa40c190b21ecebfff
https://doi.org/10.1002/jmr.300080126
https://doi.org/10.1002/jmr.300080126