Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Evzen Krepela"'
Autor:
Evzen Krepela, Zdislava Vanickova, Petr Hrabal, Michal Zubal, Barbora Chmielova, Eva Balaziova, Petr Vymola, Ivana Matrasova, Petr Busek, Aleksi Sedo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1046 (2021)
The proline-specific serine protease fibroblast activation protein (FAP) can participate in the progression of malignant tumors and represents a potential diagnostic and therapeutic target. Recently, we demonstrated an increased expression of FAP in
Externí odkaz:
https://doaj.org/article/9c1abe665d8a440eb7a05833f56f2e28
Autor:
Kamila Benkova, Albert D. Donnenberg, Yuniel Fernández-Marrero, Erika Moravcikova, Vera S. Donnenberg, Tatiana Rabachini, Thomas Kaufmann, Evzen Krepela, Daniel Bachmann
Publikováno v:
International Journal of Cancer. 141:2050-2061
Since the genomic region containing the Bcl-2-related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non-small cell lung ca
Autor:
Petr Busek, Martin Syrucek, Ivana Matrasova, Robert Tomas, Jaromir Belacek, Marek Hilser, Evzen Krepela, Aleksi Sedo, Eva Balaziova, Zuzana Zemanova
Publikováno v:
Scopus-Elsevier
Glioblastomas are deadly neoplasms resistant to current treatment modalities. Fibroblast activation protein (FAP) is a protease which is not expressed in most of the normal adult tissues but is characteristically present in the stroma of extracranial
Publikováno v:
Biochemical and biophysical research communications. 491(1)
Human tumor xenografts in mice together with the species-specific analysis of expressed genes allow to study the molecular processes driving tumor growth and progression in vivo and help to develop and evaluate anticancer therapies. In the present wo
Publikováno v:
International Journal of Oncology
The intrinsic apoptosis pathway represents an important mechanism of stress-induced death of cancer cells. To gain insight into the functional status of the apoptosome apparatus in non-small cell lung carcinoma (NSCLC), we studied its sensitivity to
Autor:
Michal Zubal, Zdislava Vanickova, P Hrabal, B Chmielova, Evzen Krepela, Aleksi Sedo, Petr Busek
Publikováno v:
Neuro Oncol
Europe PubMed Central
Europe PubMed Central
BACKGROUND Fibroblast activation protein (FAP) is a transmembrane serine protease that is frequently upregulated in the tumor microenvironment. In several cases, FAP protein itself and/or FAP expressing stromal cells have been shown to contribute to
Autor:
Jarmila Stremenova, Petr Busek, Eva Balaziova, Evzen Krepela, Aleksi Sedo, Lucie Sromova, Hynek Strnad, Dalibor Kosek, Marek Hilser, Jana Trylcova
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 44:738-747
Malignant gliomas exhibit abnormal expression of proteolytic enzymes that may participate in the uncontrolled cell proliferation and aberrant interactions with the brain extracellular matrix. The multifunctional membrane bound serine aminopeptidase d
Autor:
Petr Busek, Lucie Sromova, Libuse Lizcova, Jarmila Stremenova, Evzen Krepela, Aleksi Sedo, Eva Balaziova
Publikováno v:
Molecular and Cellular Biochemistry. 354:283-289
Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein-α (FAP) are speculated to participate in the regulation of multiple biological processes, because of their unique enzymatic activity, as well as by non-hydrolytic molecular interacti
Publikováno v:
ResearcherID
Dipeptidyl peptidase-IV (DPP-IV, CD26) is a serine protease almost ubiquitously expressed on cell surface and present in body fluids. DPP-IV has been suggested to proteolytically modify a number of biologically active peptides including substance P (
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 132:57-68
Purpose: Tumour cells killing by cytotoxic therapies largely depends on triggering the intrinsic apoptosome-mediated caspase activation pathway but it had never been evaluated whether the expression of transcripts encoding the core components of apop