Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Evžen Bouřa"'
Autor:
Luïse Robbertse, Pavla Fajtová, Pavla Šnebergerová, Marie Jalovecká, Viktoriya Levytska, Elany Barbosa da Silva, Vandna Sharma, Petr Pachl, Jehad Almaliti, Momen Al-Hindy, William H. Gerwick, Evžen Bouřa, Anthony J. O’Donoghue, Daniel Sojka
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 44989-44999 (2024)
Externí odkaz:
https://doaj.org/article/6c3cefb9eda94ba2be9cb424c6745e01
Autor:
Luca Julianna Tóth, Kateřina Krejčová, Milan Dejmek, Eva Žilecká, Blanka Klepetářová, Lenka Poštová Slavětínská, Evžen Bouřa, Radim Nencka
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1029-1036 (2024)
The RNA-dependent RNA polymerase (RdRp) represents a prominent target in the discovery and development of new antivirotics against RNA viruses, inhibiting the replication process. One of the most targeted RNA viruses of the last years is, without dou
Externí odkaz:
https://doaj.org/article/236a37cebaa444598c76d0293aeebeff
Autor:
Olivier Terrier, Sébastien Dilly, Andrés Pizzorno, Dominika Chalupska, Jana Humpolickova, Evžen Bouřa, Francis Berenbaum, Stéphane Quideau, Bruno Lina, Bruno Fève, Frédéric Adnet, Michèle Sabbah, Manuel Rosa-Calatrava, Vincent Maréchal, Julien Henri, Anny Slama-Schwok
Publikováno v:
Molecules, Vol 26, Iss 9, p 2593 (2021)
There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to prevent the most severe forms of COVID-19. By drug repurposing, affordable therapeutics could be supplied worldwide in the present pandemic context. Targeting th
Externí odkaz:
https://doaj.org/article/dab9cc3f495e4edab8a5cc709db997e4
Autor:
Jan Silhan, Pavla Fajtova, Jitka Bartosova, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto, Lars Eckmann, William H. Gerwick, Anthony J. O’Donoghue, Evzen Boura
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv), the cause of the most common, non-viral sexually transmitted disease. Tv and other p
Externí odkaz:
https://doaj.org/article/abd0f24bf800449e83e758d89f1c5a2b
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100109- (2024)
Nsp14 is an RNA methyltransferase (MTase) encoded by all coronaviruses. In fact, many viral families, including DNA viruses, encode MTases that catalyze the methylation of the RNA precap structure, resulting in fully capped viral RNA. This capping is
Externí odkaz:
https://doaj.org/article/132271903dc94f2b95a0bfb66c654966
Autor:
Michal Hocek, Radek Pohl, Nemanja Milisavljevic, Luděk Eyer, Karel Čížek, Veronika Sýkorová, Lucia Veselovská, Pavel Svoboda, Jan Weber, Jaroslav Kozák, Radim Nencka, Jan Hodek, Evžen Bouřa, Daniel Růžek, Eva Konkolova
Publikováno v:
ACS Infectious Diseases
A series of 7-deazaadenine ribonucleosides bearing alkyl, alkenyl, alkynyl, aryl, or hetaryl groups at position 7 as well as their 5'-O-triphosphates and two types of monophosphate prodrugs (phosphoramidates and S-acylthioethanol esters) were prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd123de8a69960eb62b773d0c9784b
Autor:
Zahra Aliakbar Tehrani, Martin Zavřel, Tomáš Jandušík, Andrea Brázdová, Ondrej Gutten, Radim Nencka, Gabriel Birkus, Miloš Buděšínský, Ondřej Páv, Evžen Bouřa, Markéta Pimková Polidarová, Barbora Novotna, Radek Liboska, Zdeněk Vavřina, Milan Dejmek, Miroslav Smola, Jiří Brynda, Ivan Štěpánek, Lubomír Rulíšek, Lenka Vaneková
Publikováno v:
Journal of medicinal chemistry. 62(23)
Cyclic dinucleotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which plays an important role in recognizing tumor cells and viral or bacterial infections. They bind to the STING adapto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa918f39b01eb21b81b75407db4916
https://pubmed.ncbi.nlm.nih.gov/31715099
https://pubmed.ncbi.nlm.nih.gov/31715099
Autor:
Jan Silhan, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must encode for its own RNA processing machinery includi
Externí odkaz:
https://doaj.org/article/54fb64d84fe748cfbb69a1da79700d89
Publikováno v:
FEBS Journal. 277:1270-1283
Minor structural proteins of mouse polyomavirus (MPyV) are essential for virus infection. To study their properties and possible contributions to cell death induction, fusion variants of these proteins, created by linking enhanced green fluorescent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1553e32dfd19378c43113294e4b2ca7e
https://doi.org/10.1111/j.1742-4658.2010.07558.x
https://doi.org/10.1111/j.1742-4658.2010.07558.x
Autor:
Andrea Eisenreichova, Martin Klima, Midhun Mohan Anila, Alena Koukalova, Jana Humpolickova, Bartosz Różycki, Evzen Boura
Publikováno v:
Cells, Vol 12, Iss 15, p 1974 (2023)
ORPs are lipid-transport proteins belonging to the oxysterol-binding protein family. They facilitate the transfer of lipids between different intracellular membranes, such as the ER and plasma membrane. We have solved the crystal structure of the ORP
Externí odkaz:
https://doaj.org/article/aa5771591daf43dd99f152b57f039c37