Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Evy, de Leenheer"'
Autor:
Clive Henry Buckle, Evy De Leenheer, Michelle Anne Lawson, Kwee Yong, Neil Rabin, Mark Perry, Karen Vanderkerken, Peter Ian Croucher
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41127 (2012)
Patients with multiple myeloma commonly develop focal osteolytic bone disease, as well as generalised osteoporosis. The mechanisms underlying the development of osteoporosis in patients with myeloma are poorly understood. Although disruption of the R
Externí odkaz:
https://doaj.org/article/66bee71e71264afcae99d1e5ba2efebd
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22533 (2011)
We demonstrate here a rapid alternative method for the production of functional bi-specific antibodies using the mild reducing agent 2-mercaptoethanesulfonic acid sodium salt (MESNA). Following reduction of a mixture of two monoclonal antibodies with
Externí odkaz:
https://doaj.org/article/6607d53e3c1e44dda470eaf339710ceb
Autor:
David Price, Terri C. Thayer, Dimitri Kakabadse, F. Susan Wong, Joanne Davies, James E. McLaren, Peter Huw Morgan, Kristin Ladell, James A. Pearson, Li Wen, Evy De Leenheer, Amy Phillips, Kelly L. Miners
Publikováno v:
Diabetes
NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6e8d51cc0e444193b985867b1a1620
https://doi.org/10.2337/db15-1498
https://doi.org/10.2337/db15-1498
Autor:
Joanne Davies, Evy De Leenheer, Larissa Camargo da Rosa, F. Susan Wong, Li Wen, Joanne Boldison
Publikováno v:
Diabetologia
Aims/hypothesis Type 1 diabetes is a T cell-mediated autoimmune disease characterised by the destruction of beta cells in the islets of Langerhans, resulting in deficient insulin production. B cell depletion therapy has proved successful in preventin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04ef894a04c23746d7d86d85b992ae4
Autor:
F. Susan Wong, Nathan Karin, Gideon Gross, Sigal Fishman, Joanne Davies, Alon Margalit, Evy De Leenheer, M. D. Lewis, Dimitri Kakabadse, Doron Ziv, L. Khai Siew
Chimeric major histocompatibility complex (MHC) molecules supplemented with T cell receptor (TCR) signaling motifs function as activation receptors and can redirect gene-modified T cells against pathogenic CD8 T cells. We have shown that β 2 microgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18714a7932277ef66dfe38c55ec8f415
https://orca.cardiff.ac.uk/id/eprint/105594/1/1-s2.0-S1525001616454298-main.pdf
https://orca.cardiff.ac.uk/id/eprint/105594/1/1-s2.0-S1525001616454298-main.pdf
Autor:
Evy, De Leenheer, F Susan, Wong
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1433
Studying Type 1 Diabetes (T1D) in the nonobese diabetic (NOD) mouse model can be cumbersome as onset of disease does not usually occur naturally prior to the age of 12-14 weeks and is often restricted to female mice. Furthermore, the onset of disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1dd055c1439be4a80e1cee9acdbf22e
https://pubmed.ncbi.nlm.nih.gov/26791362
https://pubmed.ncbi.nlm.nih.gov/26791362
Autor:
Eline Menu, Hendrik De Raeve, Karin Vanderkerken, Evy De Leenheer, Kenneth Nilsson, Les Coulton, Olle Larsson, Magnus Axelson, Orla Gallagher, Peter I. Croucher, Ben Van Camp, Helena Jernberg-Wiklund, Els Van Valckenborgh
Publikováno v:
Vrije Universiteit Brussel
During the last decade, a central role for insulin-like growth factor 1 (IGF-1) in the pathophysiology of multiple myeloma (MM) has been well established. IGF-I provided by the tumor-microenvironment interaction may directly and indirectly facilitate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf145436cd167e3b67db3917cc660a6c
https://doi.org/10.1002/ijc.22845
https://doi.org/10.1002/ijc.22845
Autor:
Peter Easton, Joanne Boldison, Stephanie J. Hanna, Lai Khai Siew, James A. Pearson, Adrian Tsui, Li Wen, Terri C. Thayer, Sartaj Ahmed, F. Susan Wong, Evy De Leenheer, Joanne Davies
Publikováno v:
Diabetes. 65(11)
Low-avidity autoreactive CD8 T cells (CTLs) escape from thymic negative selection, and peripheral tolerance mechanisms are essential for their regulation. We report the role of proinsulin (PI) expression on the development and activation of insulin-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8422e6a2efec236558049c58081aaf66
https://pubmed.ncbi.nlm.nih.gov/27495224
https://pubmed.ncbi.nlm.nih.gov/27495224
Autor:
F. Susan Wong, Evy De Leenheer
Publikováno v:
Methods in Molecular Biology ISBN: 9781493936410
Studying Type 1 Diabetes (T1D) in the nonobese diabetic (NOD) mouse model can be cumbersome as onset of disease does not usually occur naturally prior to the age of 12-14 weeks and is often restricted to female mice. Furthermore, the onset of disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b479f9b224c604d9ea7b61b6518e8c2b
https://doi.org/10.1007/7651_2015_294
https://doi.org/10.1007/7651_2015_294
Autor:
Ben Van Camp, Agnès Noël, S. Blacher, Hendrik De Raeve, Peter I. Croucher, Evy De Leenheer, Elke De Bruyne, Kewal Asosingh, Chris P. Carron, Laetitia Devy, Karin Vanderkerken, Ivan Van Riet, Els Van Valckenborgh
Publikováno v:
The American Journal of Pathology. 165:869-878
Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3f57a08740df5dd35a931b37a43847
https://doi.org/10.1016/s0002-9440(10)63349-4
https://doi.org/10.1016/s0002-9440(10)63349-4