Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Evrim Gurpinar"'
Autor:
Ruiwen Zhang, Wei Wang, Sadanandan E. Velu, Xinyi Yang, Charnell I. Sommers, Elizabeth R. Rayburn, Xu Zhang, Evrim Gurpinar, Hongxia Xu, Xiangrong Zhang, Scharri J. Ezell, Haibo Li
Publikováno v:
Marine Drugs, Vol 8, Iss 7, Pp 2129-2141 (2010)
Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaff
Externí odkaz:
https://doaj.org/article/93dce1ef7e914decbb5a9501a249ad62
Autor:
Jacob Valiyaveettil, Meagan Thomas, Xi Chen, Brian T. Eberhardt, Ashley S. Lindsey, Larry Yet, Luciana Madeira da Silva, John T. Piazza, Joshua C. Canzoneri, Dennis Otali, Kevin Lee, Gary A. Piazza, Alexandra M. Fajardo, Adam B. Keeton, Nan Li, Veronica Ramirez-Alcantara, Bing Zhu, William E. Grizzle, Evrim Gurpinar
Publikováno v:
Oncotarget
// Bing Zhu 1 , Ashley Lindsey 1 , Nan Li 2 , Kevin Lee 1 , Veronica Ramirez-Alcantara 1 , Joshua C. Canzoneri 1 , Alexandra Fajardo 1 , Luciana Madeira da Silva 1 , Meagan Thomas 1 , John T. Piazza 1 , Larry Yet 3 , Brian T. Eberhardt 3 , Evrim Gurp
Autor:
Evrim Gurpinar, Karen H. Vousden
Publikováno v:
Trends in Cell Biology. 25:486-495
The tumor suppressor protein p53 plays a critical role in limiting malignant development and progression. Almost all cancers show loss of p53 function, through either mutation in the p53 gene itself or defects in the mechanisms that activate p53. Whi
Autor:
Kevin Lee, Alexandra M. Fajardo, Bernard D. Gary, Suzanne Russo, Evrim Gurpinar, Mary Pat Moyer, Veronica Ramirez-Alcantara, John T. Piazza, Xi Chen, Sara Sigler, Adam B. Keeton, Danuel J. Laan, Wenyan Lu, Meagan Thomas, Yonghe Li, Yaguang Xi, Joshua C. Canzoneri, Joel Andrews, Larry Yet, Gary A. Piazza, Nan Li, William E. Grizzle, Brian T. Eberhardt, Bing Zhu
Publikováno v:
Oncogene
The cyclic nucleotide phosphodiesterase 10A (PDE10) has been mostly studied as a therapeutic target for certain psychiatric and neurological conditions, although a potential role in tumorigenesis has not been reported. Here we show that PDE10 is elev
Publikováno v:
Clinical Cancer Research. 20:1104-1113
Numerous epidemiologic studies have reported that the long-term use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with a significant decrease in cancer incidence and delayed progression of malignant disease. The use of NSAIDs has also
Autor:
Xu Zhang, Haibo Li, Scharri J. Ezell, Xiangrong Zhang, Xinyi Yang, Elizabeth R. Rayburn, Charnell I. Sommers, Sadanandan E. Velu, Evrim Gurpinar, Hongxia Xu, Wei Wang, Ruiwen Zhang
Publikováno v:
Biomedical Chromatography. 25:628-634
We herein describe the development and validation of a high performance liquid chromatography (HPLC) method for the quantitation of 7-(benzylamino)-1, 3, 4, 8-tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one (BA-TPQ), a newly synthesized iminoquinone
Publikováno v:
Davis, C, Naci, H, Gurpinar, E, Poplavska, E, Pinto, A & Aggarwal, A 2017, ' Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency : retrospective cohort study of drug approvals 2009-13 ', BMJ (Clinical research ed.), vol. 359, no. 8124, pp. j4530 . https://doi.org/10.1136/bmj.j4530
Objective To determine the availability of data on overall survival and quality of life benefits of cancer drugs approved in Europe. Design Retrospective cohort study. Setting Publicly accessible regulatory and scientific reports on cancer approvals
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 3 (2013)
Frontiers in Oncology, Vol 3 (2013)
Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of developing cancer. Experimental studies in human cancer cell lines and rodent
Autor:
Nan Li, Bernard D. Gary, Wen-Chi Chang, Xi Chen, William E. Grizzle, Evrim Gurpinar, Yaguang Xi, Yonghe Li, Heather N. Tinsley, Margie L. Clapper, Mary Pat Moyer, Bing Zhu, Adam B. Keeton, Ashraf H. Abadi, Gary A. Piazza
Publikováno v:
Molecular cancer therapeutics. 12(9)
Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity for colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for chemoprevention. Previous studies have concluded that the basis f
Autor:
Adam B. Keeton, Suzanne Russo, John J. Shacka, William E. Grizzle, Gary A. Piazza, Nan Li, Burton J. Mader, Nicholas A. Piazza, Evrim Gurpinar
Publikováno v:
Molecular cancer therapeutics. 12(5)
Nonsteroidal anti-inflammatory drugs such as sulindac sulfide have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from COX inhibition limit their use in cancer therapy. We recently described a N,N-dimethylet