Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy.

Autor: Zborowsky S; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France.; These authors contributed equally., Seurat J; Institut de Biologie, Ecole Normale Supérieure, Paris 75005, France.; School of Biological Sciences, Georgia Institute of Technology, Atlanta GA 30332, USA.; These authors contributed equally., Balacheff Q; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France.; CHU Felix Guyon, Service des maladies respiratoires, La Réunion, France., Ecomard S; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France.; DGA, Paris 75015, France.; Sorbonne Université, Collège Doctoral, Paris, France., Nguyen Ngoc Minh C; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France.; Sorbonne Université, Collège Doctoral, Paris, France., Titécat M; Université de Lille, INSERM, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, Lille 59000, France., Evrard E; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France., Rodriguez-Gonzalez RA; School of Biological Sciences, Georgia Institute of Technology, Atlanta GA 30332, USA.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta GA 30332, USA., Marchi J; Department of Biology, University of Maryland, College Park MD 20742, USA., Weitz JS; Institut de Biologie, Ecole Normale Supérieure, Paris 75005, France.; School of Biological Sciences, Georgia Institute of Technology, Atlanta GA 30332, USA.; Department of Biology, University of Maryland, College Park MD 20742, USA., Debarbieux L; Institut Pasteur, Université Paris Cité, Bacteriophage Bacterium Host, Paris 75015, France.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 06. Date of Electronic Publication: 2024 Jun 06.