Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Evonne McArthur"'
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Establishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these patterns drive cellular phenotypes is unclear. While > 80% of CpG sites are stably methylate
Externí odkaz:
https://doaj.org/article/8465ab5e610b4941a3e2b0a0610e8ae5
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
We lack a comprehensive understanding of how Neanderthal ancestry influences human traits. This study finds that regions with Neanderthal ancestry are broadly depleted of trait-associated variation; yet, introgressed variants likely contributed to hu
Externí odkaz:
https://doaj.org/article/8acc0daaafc348918762f887dd73867e
Publikováno v:
Indian Journal of Community Medicine, Vol 41, Iss 1, Pp 62-64 (2016)
Background: In India, only one woman is diagnosed with tuberculosis (TB) for every 2.4 men. Previous studies have indicated gender disparities in care-seeking behavior and TB diagnosis; however, little is known about the specific barriers women face.
Externí odkaz:
https://doaj.org/article/a083711d086f412eaf297b38f4361189
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140885 (2015)
Genome-wide association studies aim to correlate genotype with phenotype. Many common diseases including Type II diabetes, Alzheimer's, Parkinson's and Chronic Obstructive Pulmonary Disease (COPD) are complex genetic traits with hundreds of different
Externí odkaz:
https://doaj.org/article/95550644295844d2b30f4d0077874646
Autor:
Laura Gunsalus, Evonne McArthur, Ketrin Gjoni, Shuzhen Kuang, Maureen Pittman, John Capra, Katherine Pollard
Comparing chromatin contact maps is an essential step in quantifying how three-dimensional (3D) genome organization shapes development, evolution, and disease. However, no gold standard exists for comparing contact maps, and even simple methods often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90770b54f4320275ae8d76061c935ec9
https://doi.org/10.21203/rs.3.rs-2842981/v1
https://doi.org/10.21203/rs.3.rs-2842981/v1
Autor:
Laura M. Gunsalus, Evonne McArthur, Ketrin Gjoni, Shuzhen Kuang, Maureen Pittman, John A. Capra, Katherine S. Pollard
Comparing chromatin contact maps is an essential step in quantifying how three-dimensional (3D) genome organization shapes development, evolution, and disease. However, no gold standard exists for comparing contact maps, and even simple methods often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9f6f1856bfa3ebbb388e857144b2e0
https://doi.org/10.1101/2023.04.04.535480
https://doi.org/10.1101/2023.04.04.535480
Autor:
Keila Velazquez-Arcelay, Laura L. Colbran, Evonne McArthur, Colin Brand, Justin Siemann, Douglas McMahon, John A. Capra
Publikováno v:
bioRxiv
IntroductionWhen the ancestors of modern Eurasians migrated out of Africa and interbred with Eurasian archaic hominins, namely Neanderthals and Denisovans, DNA of archaic ancestry integrated into the genomes of anatomically modern humans. This proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5e4050e658664b0c11c9a006849f83
https://doi.org/10.1101/2023.02.03.527061
https://doi.org/10.1101/2023.02.03.527061
Publikováno v:
JAMIA Open. 6
Enabling discovery across the spectrum of rare and common diseases requires the integration of biological knowledge with clinical data; however, differences in terminologies present a major barrier. For example, the Human Phenotype Ontology (HPO) is
Establishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these patterns drive cellular phenotypes is unclear. While >80% of CpG sites are stably methylated, tens of thousands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1803e6224fef9e0ee3e90d77334736d
https://doi.org/10.1101/2022.12.15.520535
https://doi.org/10.1101/2022.12.15.520535
Autor:
David C. Rinker, Evonne McArthur, Emily Hodges, Douglas Shaw, Corinne N. Simonti, John A. Capra
Publikováno v:
Nature ecology & evolution
Neanderthal ancestry remains across modern Eurasian genomes, and introgressed sequences influence diverse phenotypes. Here we demonstrate that introgressed sequences reintroduced thousands of ancestral alleles that were lost in Eurasian populations p