Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22

Autor: Elina A. Kiss, Max Löhning, Michael Lohoff, Andreas Diefenbach, Magdalena Huber, Anna Guralnik, Kerstin Kellner, Hartmann Raifer, Nadine Bollig, Stephanie C. Ganal, Anne Hellhund, Evita Bothur, Katharina Reinhard, Thomas Korn, Stefan Bauer, Azita J. Mahiny, Franziska Petermann

Publikováno v: European Journal of Immunology. 42:3189-3201

Apart from conventional CD4(+) Th17 cells, the cytokines IL-17A and IL-22 can also be produced by γδ T cells, NK cells and lymphoid tissue inducer (LTi) cells. Th17 cells develop from precursor cells after T-cell receptor stimulation in the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a198a7c5430a8b29ba3149b2cd1c0b0c
https://doi.org/10.1002/eji.201142155

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

Autor: Uta-Maria Bauer, Cholho Kang, Anne Brüstle, Evita Bothur, Andreas Radbruch, Maria Bieringer, Michael Lohoff, Anna-Barbara Stittrich, Katharina Reinhard, Magdalena Huber, Alexander Visekruna, Nadine Bollig, Ulrich Steinhoff, Dirk Brenner, Claudia Haftmann, Hartmann Raifer, Bärbel Camara, Veronika Sexl, Tim Sparwasser, Mir-Farzin Mashreghi, Antje Repenning, Tak Wah Mak

Publikováno v: Bothur, E, Raifer, H, Haftmann, C, Stittrich, A B, Brustle, A, Brenner, D, Bollig, N, Bieringer, M, Kang, C H, Reinhard, K, Camara, B, Huber, M, Visekruna, A, Steinhoff, U, Repenning, A, Bauer, U M, Sexl, V, Radbruch, A, Sparwasser, T, Mashreghi, M F, Mak, T W & Lohoff, M 2015, ' Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1 ', Nature Communications, vol. 6, 8576 . https://doi.org/10.1038/ncomms9576
Nature Communications

Regulatory T-cells induced via IL-2 and TGFβ in vitro (iTreg) suppress immune cells and are potential therapeutics during autoimmunity. However, several reports described their re-differentiation into pathogenic cells in vivo and loss of their key f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30b213907771a43d96a680b4f68e0a9
https://portal.findresearcher.sdu.dk/da/publications/ae0fa504-460b-4cb8-bf5e-cf8259ece534

Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22

Autor: Hartmann, Raifer, Azita J, Mahiny, Nadine, Bollig, Franziska, Petermann, Anne, Hellhund, Kerstin, Kellner, Anna, Guralnik, Katharina, Reinhard, Evita, Bothur, Magdalena, Huber, Stefan, Bauer, Max, Löhning, Elina A, Kiss, Stephanie C, Ganal, Andreas, Diefenbach, Thomas, Korn, Michael, Lohoff

Publikováno v: European journal of immunology. 42(12)

Apart from conventional CD4(+) Th17 cells, the cytokines IL-17A and IL-22 can also be produced by γδ T cells, NK cells and lymphoid tissue inducer (LTi) cells. Th17 cells develop from precursor cells after T-cell receptor stimulation in the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7f2c95c84f7f2ce8716f70f3dfe481c
https://pubmed.ncbi.nlm.nih.gov/22961652

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells

Autor: Sebastian Reuter, Karen Lingnau, Matthias Klein, Tobias Bopp, Valérie Staudt, Marc Becker, Andrea Steinborn, Alexander Ulges, Nadine Grebe, Michael Stassen, Edgar Schmitt, Hansjörg Schild, Evita Bothur, Markus Hoffmann, Christian Taube, Bastian Gerlitzki, Michael Lohoff, Nina Dehzad

Publikováno v: Immunity. 33(2)

Summary Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and function of an interleukin-9 (IL-9)-producing CD4 + T cell subset d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9c164d6a067929d582d0b811434cc
https://pubmed.ncbi.nlm.nih.gov/20732634