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Akademický článek

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Neuroinflammation in the central nervous system (CNS), driven largely by resident phagocytes, has been proposed as a significant contributor to disability accumulation in multiple sclerosis (MS) but has not been addressed therapeutically. Br

Externí odkaz: https://doaj.org/article/7240258f9fe44a898fcf295ec6f91164

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Sustained reduction of serum neurofilament light chain over 7 years by alemtuzumab in early relapsing–remitting MS

Autor: Nora Rӧsch, Christian Barro, Zuzanna Michalak, Jens Kuhle, Carina Kaiser, Colin Mitchell, Aleksandra Maceski, Maria Pia Sormani, Jean Godin, Ludwig Kappos, David Leppert, Luke Chung, Alan Jacobs, Srinivas Shankara, Pascal Benkert, Evis Havari, Nadia Daizadeh, Tarek A Samad

Publikováno v: Multiple Sclerosis Journal. 28:573-582

Background: Alemtuzumab efficacy and safety was demonstrated in CARE-MS I and extension studies (CAMMS03409; TOPAZ). Objective: Evaluate serum neurofilament light chain (sNfL) in CARE-MS I patients and highly active disease (HAD) subgroup, over 7 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344820f55c4a23065e16311d792d37cc
https://doi.org/10.1177/13524585211032348

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Impact of alemtuzumab treatment on the survival and function of human regulatory T cellsin vitro

Autor: Johanne Kaplan, William M. Siders, Evis Havari, Tri-Hung Nguyen, Michael J. Turner, Srinivas Shankara, Bruce L. Roberts, Juanita Campos-Rivera

Publikováno v: Immunology. 141:123-131

Alemtuzumab is a humanized monoclonal antibody specific for the CD52 protein present at high levels on the surface of B and T lymphocytes. In clinical trials, alemtuzumab has shown a clinical benefit superior to that of interferon-β in relapsing-rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358e7811dab3cf815ccff2532ed9c01
https://doi.org/10.1111/imm.12178

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Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans

Autor: Evis Havari, HuiJuan Lv, Roderick T. Bronson, Kai W. Wucherpfennig, Bruno Kyewski, Myra A. Lipes, Shannon J. Turley, Raju V. S. R. K. Gottumukkala, Anne L. Fletcher, Ross O. Smith, Sheena Pinto, Khadir Raddassi, Anthony Rosenzweig, Lizbeth Cornivelli, Takashi Matsui

Publikováno v: Journal of Clinical Investigation. 121:1561-1573

Autoimmunity has long been linked to myocarditis and its sequela, dilated cardiomyopathy, the leading causes of heart failure in young patients. However, the underlying mechanisms are poorly defined, with most clinical investigations focused on humor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20199e382883a91197bd1bc761dfed2a
https://doi.org/10.1172/jci44583

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A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ8

Autor: Roderick T. Bronson, Myra A. Lipes, Jacqueline A. Taylor, Evis Havari, Kai W. Wucherpfennig, Marcia F. McInerney

Publikováno v: The Journal of Immunology. 172:2651-2658

Genome-wide analyses have shown that the MHC class II region is the principal locus that confers susceptibility to a number of human autoimmune diseases. Due to the high degree of linkage disequilibrium across the MHC, it has been difficult to dissec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5d706962d81a51a688e5e098c5dc4d
https://doi.org/10.4049/jimmunol.172.4.2651

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Expression of TMPRSS4 in non-small cell lung cancer and its modulation by hypoxia

Autor: Rebecca G. Bagley, Evis Havari, Stephen L. Madden, Rajashree McLaren, William Weber, Tri-Hung Nguyen, Timothy D. Connors, Johanne Kaplan, Bruce L. Roberts, Beverly A. Teicher, Prashant R. Nambiar, Srinivas Shankara

Publikováno v: International Journal of Oncology

Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575a711313e53c3081a34f2b02c165c2
https://pubmed.ncbi.nlm.nih.gov/22692880

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Alemtuzumab induction of intracellular signaling and apoptosis in malignant B lymphocytes

Autor: Rajashree McLaren, Johanne Kaplan, Stephen L. Madden, Srinivas Shankara, Mindy Zhang, Yide Jiang, Evis Havari, Bruce L. Roberts, Tri-Hung Nguyen

Publikováno v: Leukemialymphoma. 53(4)

The molecular changes induced by alemtuzumab following binding of CD52 on B tumor cells were investigated. Alemtuzumab alone had no detectable impact on cell signaling but cross-linking of alemtuzumab on the surface of B tumor lines with anti-human F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4447dae1d483444a8c978602271089
https://pubmed.ncbi.nlm.nih.gov/21916527

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Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes

Autor: Ana-Maria Lennon-Duménil, Marcia F. McInerney, Jacqueline A. Taylor, Devon Neely, Kai W. Wucherpfennig, Myra A. Lipes, Ludger Klein, Evis Havari

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 173(2)

Although HLA-DQ8 has been implicated as a key determinant of genetic susceptibility to human type 1 diabetes, spontaneous diabetes has been observed in HLA-DQ8 transgenic mice that lack expression of murine MHC class II molecules (mII−/−) only wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9881de5c91736df9db45f8ec2e917bef
https://pubmed.ncbi.nlm.nih.gov/15240665

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