Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

Autor: Anna Petryk, Catherine M. Verfaillie, Lieve Coenegrachts, Evis Daci, Karen Moermans, Ingrid Stockmans, Peter Carmeliet, Aernout Luttun, Geert Carmeliet, Rajaram Gopalakrishnan, Roger Bouillon, Christa Maes, Nico Smets

Publikováno v: Journal of Clinical Investigation. 116:1230-1242

Current therapies for delayed- or nonunion bone fractures are still largely ineffective. Previous studies indicated that the VEGF homolog placental growth factor (PlGF) has a more significant role in disease than in health. Therefore we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafc67bc35d68d54e686860e788bf48c
https://doi.org/10.1172/jci26772

Plasminogen activators are involved in the degradation of bone by osteoclasts

Autor: Geert Carmeliet, Kees A. Hoeben, Vincent Everts, Sophie Torrekens, Evis Daci, Wouter Beertsen, Wikky Tigchelaar-Gutter

Publikováno v: Bone, 43(5), 915-920. Elsevier Inc.
Everts, V, Daci, E, Tigchelaar-Gutter, W, Hoeben, K A, Torrekens, S, Carmeliet, G & Beertsen, W 2008, ' Plasminogen activators are involved in the degradation of bone by osteoclasts ', Bone, vol. 43, no. 5, pp. 915-920 . https://doi.org/10.1016/j.bone.2008.07.004
Bone, 43(5), 915-920. Elsevier

Osteoclastic bone degradation depends on the activity of several proteolytic enzymes, in particular to those belonging to the classes of cysteine proteinases and matrix metalloproteinases (MMPs). Yet, several findings suggest that the two types of pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a905ef49ec2976ed06783fa2a86c8d
https://pure.amc.nl/en/publications/plasminogen-activators-are-involved-in-the-degradation-of-bone-by-osteoclasts(615cd147-55b2-42b0-815f-450f7dba6b52).html

The Role of Plasminogen in Bone Remodeling

Autor: Evis Daci, E H Allan, T. John Martin

Publikováno v: Plasminogen: Structure, Activation, and Regulation ISBN: 9781461349495

The processes of bone formation and resorption are continuous throughout life and are necessary for the maintenance of a normal functional skeleton. Bone formation by cells of the osteoblast lineage results from the synthesis of matrix followed by mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::693fed7f38bdb72387eed901c1a04f7a
https://doi.org/10.1007/978-1-4615-0165-7_14

Mice lacking the plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency

Autor: Roger Bouillon, Annemieke Verstuyf, Geert Carmeliet, Evis Daci, Karen Moermans

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 15(8)

Bone turnover requires the interaction of several proteases during the resorption phase. Indirect evidence suggests that the plasminogen activator/plasmin pathway is involved in bone resorption and turnover, and recently we have shown that this casca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7e41f600dc6a4a529de1f96bd2ecdb
https://pubmed.ncbi.nlm.nih.gov/10934649

The role of the plasminogen system in bone resorption in vitro

Autor: Geert Carmeliet, Nobuyuki Udagawa, Evis Daci, Thomas J. Martin, Roger Bouillon

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(6)

The plasminogen/plasmin proteolytic cascade plays an important role in extracellular matrix remodeling. The presence of the two plasminogen activators (PAs), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77901bf46b6b61692dd6591368a5099e
https://pubmed.ncbi.nlm.nih.gov/10352103