Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Evilevitch A"'
Autor:
Wei Guo, Manish R Patel, Nashat Gabrail, Jordi Rodon, Erika Hamilton, Timothy A Yap, Meghan Duncan, Alberto Bessudo, Jasgit Sachdev, Lena Evilevitch, Sujatha Kumar, Sharon Lu, Bruce J Dezube
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Doublet combination therapies targeting immune checkpoints have shown promising efficacy in patients with advanced solid tumors, but it is unknown if rational triplet combinations will be well tolerated and associated with improved antitum
Externí odkaz:
https://doaj.org/article/e29828d5a2dc440fb2aab02626d02441
Publikováno v:
QRB Discovery, Vol 3 (2022)
The viral replication cycle is controlled by information transduced through both molecular and mechanical interactions. Viral infection mechanics remains largely unexplored, however, due to the complexity of cellular mechanical responses over the cou
Externí odkaz:
https://doaj.org/article/16a3b4abd7064ebbba994ab0dfea5a3a
Autor:
Nurmemmedov, Elmar, Castelnovo, Martin, Medina, Elizabeth, Catalano, Carlos Enrique, Evilevitch, Alex
The terminase motors of bacteriophages have been shown to be among the strongest active machines in the biomolecular world, being able to package several tens of kilobase pairs of viral genome into a capsid within minutes. Yet these motors are hinder
Externí odkaz:
http://arxiv.org/abs/1111.2143
DNA heats up : Energetics of genome ejection from phage revealed by isothermal titration calorimetry
Most bacteriophages are known to inject their double-stranded DNA into bacteria upon receptor binding in an essentially spontaneous way. This downhill thermodynamic process from the intact virion toward the empty viral capsid plus released DNA is mad
Externí odkaz:
http://arxiv.org/abs/1001.0877
Recent in vitro experiments have shown that DNA ejection from bacteriophage can be partially stopped by surrounding osmotic pressure when ejected DNA is digested by DNase I on the course of ejection. We argue in this work by combination of experiment
Externí odkaz:
http://arxiv.org/abs/0806.3835
Autor:
Castelnovo, Martin, Evilevitch, Alex
Publikováno v:
The European Physical Journal E 24 (2007) 9-18
We present in this work in vitro measurements of the force ejecting DNA from two distinct bacteriophages (T5 and lambda) using the smotic-suppression technique. Our data are analyzed by revisiting the current theories of DNA packaging in spherical ca
Externí odkaz:
http://arxiv.org/abs/0712.2919
Autor:
Castelnovo, Martin, Evilevitch, Alex
Publikováno v:
Europhysics Letters 73 (06/01/2006) 635-641
The classical Gibbs-Donnan equilibrium describes excess osmotic pressure associated with confined colloidal charges embedded in an electrolyte solution. In this work, we extend this approach to describe the influence of multivalent ion binding on the
Externí odkaz:
http://arxiv.org/abs/physics/0512164
Autor:
Grayson, Paul, Evilevitch, Alex, Inamdar, Mandar M., Purohit, Prashant K., Gelbart, William M., Knobler, Charles M., Phillips, Rob
A variety of viruses tightly pack their genetic material into protein capsids that are barely large enough to enclose the genome. In particular, in bacteriophages, forces as high as 60 pN are encountered during packaging and ejection, produced by DNA
Externí odkaz:
http://arxiv.org/abs/q-bio/0505042
We discuss how a balance can be established between the force acting to eject DNA from viral capsids and the force resisting its entry into a colloidal suspension which mimics the host cell cytoplasm. The ejection force arises from the energy stored
Externí odkaz:
http://arxiv.org/abs/physics/0403057
Publikováno v:
PLoS Pathogens, Vol 16, Iss 7, p e1008604 (2020)
Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to tre
Externí odkaz:
https://doaj.org/article/d33b2c0fa75f472ea230f5bbc67ad0bb