Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Evi Stegmann"'
Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides
Autor:
Mathias H. Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max J. Cryle, Nadine Ziemert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Antibiotics are central to modern medicine, and yet they are mainly the products of intra and inter-kingdom evolutionary warfare. To understand how nature evolves antibiotics around a common mechanism of action, we investigated the origins o
Externí odkaz:
https://doaj.org/article/f33678345ca34f409dcf274d94b63533
Autor:
Julia Gottstein, Julia Zaschke-Kriesche, Sandra Unsleber, Irina Voitsekhovskaia, Andreas Kulik, Lara V. Behrmann, Nina Overbeck, Kai Stühler, Evi Stegmann, Sander H. J. Smits
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Treatment of bacterial infections is one of the major challenges of our time due to the evolved resistance mechanisms of pathogens against antibiotics. To circumvent this problem, it is necessary to understand the mode of action of the drug
Externí odkaz:
https://doaj.org/article/498c4eaaaf0242af97e1f185298e7d9b
Autor:
Anja Greule, Thierry Izoré, Dumitrita Iftime, Julien Tailhades, Melanie Schoppet, Yongwei Zhao, Madeleine Peschke, Iftekhar Ahmed, Andreas Kulik, Martina Adamek, Robert J. A. Goode, Ralf B. Schittenhelm, Joe A. Kaczmarski, Colin J. Jackson, Nadine Ziemert, Elizabeth H. Krenske, James J. De Voss, Evi Stegmann, Max J. Cryle
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Kistamicin is a structurally divergent glycopeptide antibiotic (GPA) that contains a unique 15-membered A-O-B ring. Here, the authors obtained a crystal structure of the kistamicin OxyA/X-domain complex and analysed the cyclisation cascade leading to
Externí odkaz:
https://doaj.org/article/09b465696c784ff3b63bbdc04e4fd0ff
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/51971cdf71824e8b8c84508383c16874
Publikováno v:
Synthetic and Systems Biotechnology, Vol 3, Iss 1, Pp 56-63 (2018)
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin has been hampered since the producer str
Externí odkaz:
https://doaj.org/article/32f9447e534e4a0891154e9df9e9ac3d
Autor:
Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber
Publikováno v:
Molecules, Vol 26, Iss 21, p 6580 (2021)
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by heter
Externí odkaz:
https://doaj.org/article/86badcd3f9eb4ba6bb5883784ca814da
Autor:
Yvonne Mast, Evi Stegmann
Publikováno v:
Antibiotics, Vol 8, Iss 3, p 105 (2019)
Actinomycetes are well known as an inexhaustible source for antibiotics [...]
Externí odkaz:
https://doaj.org/article/0f900c4e20ec4600b61332b80146fbb5
Autor:
Syeda T. Towhid, Eva-Maria Schmidt, Alexander Tolios, Patrick Münzer, Evi Schmid, Oliver Borst, Meinrad Gawaz, Evi Stegmann, Florian Lang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 31, Iss 1, Pp 102-112 (2013)
Background/Aims: Side effects of vancomycin, a widely used antibiotic, include thrombocytopenia. The vancomycin-induced thrombocytopenia has been attributed to immune reactions. At least in theory, thrombocytopenia could result in part from the trigg
Externí odkaz:
https://doaj.org/article/a73c7097c6144e94a9ff9fd2a61f0edb
Autor:
Valentina Goldfinger, Marius Spohn, Jens-Peter Rodler, Melanie Sigle, Andreas Kulik, Max J. Cryle, Johanna Rapp, Hannes Link, Wolfgang Wohlleben, Evi Stegmann
Publikováno v:
Metabolic Engineering. 78:84-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::241c978fd717df4a40532a74780e27c9
https://doi.org/10.1016/j.ymben.2023.05.005
https://doi.org/10.1016/j.ymben.2023.05.005
Publikováno v:
Organic Chemistry Frontiers. 9:2714-2720
Four stereoisomeric and isotopically labelled probes that are suitable to easily follow the stereochemical course of dehydratases have been synthesised.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0315fd9ac7f95f848b43d4d858cfa1ce
https://doi.org/10.1039/d2qo00272h
https://doi.org/10.1039/d2qo00272h